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It is not known exactly where amyloid-β (Aβ) fibrils begin to accumulate in individuals with Alzheimer's disease (AD). Recently, we showed that abnormal levels of Aβ42 in cerebrospinal fluid (CSF) can be detected before abnormal amyloid can be detected using PET in individuals with preclinical AD. Using these approaches, here we identify the earliest preclinical AD stage in subjects from the ADNI

Multilevel data occur frequently in many research areas like health services research and epidemiology. A suitable way to analyze such data is through the use of multilevel regression models. These models incorporate cluster-specific random effects that allow one to partition the total variation in the outcome into between-cluster variation and between-individual variation. The magnitude of the ef

Irritable bowel syndrome (IBS) is a gut-brain disorder involving alterations in intestinal sensitivity and motility. Serotonin 5-HT4 receptors are promising candidates in IBS pathophysiology since they regulate gut motor function and stool consistency, and targeted 5-HT4R selective drug intervention has been proven beneficial in subgroups of patients. We identified a single nucleotide polymorphism

PURPOSE: The purpose of this study is to investigate the relationship between sociodemographic factors and pharmacy dispensing of medications for erectile dysfunction (ED) in the general population of middle-aged and elderly men. By considering a number of medical conditions that could promote or contraindicate use of ED medication, the analysis could help capture prescription patterns that might

CO2 has a strong impact on both operability and emission behaviours in gas turbine combustors. In the present study, an atmospheric, preheated, swirl-stabilised optical gas turbine model combustor rig was employed. The primary objectives were to analyse the influence of CO2 on the fundamental characteristics of combustion, lean blowout (LBO) limits, CO emission and flame structures. CO2 dilution e

Purpose: This study investigated sleep, television, computer habits, and obesity in school-age children. Design and methods: This was a cross-sectional self-report survey of 1260 children in grade 4 (mean age, 10.1) living in southern Sweden (49.1% boys). The heights and weights of 1097 (87.1%) of the children were recorded. Descriptive statistics, bivariate analyses, and multiple logistic regress

This study aims to determine risk factors contributing to traffic crashes in 9,176 fatal cases involving motorcycle in Malaysia between 2010 and 2012. For this purpose, both multinomial and mixed models of motorcycle fatal crash outcome based on the number of vehicle involved are estimated. The corresponding model predicts the probability of three fatal crash outcomes: motorcycle single-vehicle fa

The number of triangulations of a planar n point set S is known to be cn, where the base c lies between 2.43 and 30. Similarly, the number of crossing-free spanning trees on S is known to be dn, where the base d lies between 6.75 and 141.07. The fastest known algorithm for counting triangulations of S runs in 2(1+o(1))nlog n time while that for counting crossing-free spanning trees runs in O (7.12

The study of solvation in pressurized systems requires in situ analysis. An optimal spectroscopic technique for such studies would enable the detection of any compound and have resolution enough to differentiate different compounds within a multicomponent mixture. Here we show for the first time that we can follow dissolution kinetics of a model compound, d-limonene, in supercritical carbon dioxid

The purpose of the present study was to investigate the intercomprehension processes of multilingual Swedish L1 speakers while reading and decoding text in Italian, an unknown language. The three Swedish L1 participants in the present case study had English as L2 and respectively French, Spanish and German as L3. The participants read two texts in Italian, a language unknown to them, and using thi

Laser spectroscopy has a multitude of applications of importance to human and ecosystem well-being, such as in the environmental, ecological, agricultural and food safety areas. Recent work, mostly from SCNU, will be reviewed.

Laser based spectroscopic techniques can be used in the detection and therapy of many human diseases. Examples will be given from a variety of clinical areas, such as oncology, orthopedics and pediatrics, and also from the field of food safety and antibiotic control.

NanoMAX is a hard x-ray nanoimaging beamline at the new Swedish synchrotron radiation source MAX IV that became operational in 2016. Being a beamline dedicated to x-ray nanoimaging in both 2D and 3D, NanoMAX is the first to take full advantage of MAX IVs exceptional low emittance and resulting coherent properties. We present results from the first experiments at NanoMAX that took place in December

Based on linked employer-employee panel data on all Swedish inventors, this paper analyses how wages affect inventors' job mobility. It is commonly assumed that higher wages reduce mobility because they reduce the value of outside opportunities. We argue that higher wages also send performance signals to potential employers, who raise their wage offers in response. By disentangling the effects of

This paper addresses how to identify attack relations on the basis of lay arguers’ acceptability-judgments for natural language arguments. We characterize argument-based reasoning by three Bayesian network models (coherent, decisive, and positional). Each model yields a different attack relation-estimate. Subsequently, we analyze to which extent estimates are consistent with, and so could potentia

Organtransplantation har under de senaste decennierna utvecklats från att vara en experimentell behandling till att bli huvudbehandling för en rad sjukdomar. Förbättringar i immundämpande behandlingar anses generellt vara en av huvudorsakerna till denna utveckling, som också har medfört bättre utfall i form av överlevnad och livskvalitet. Under samma tidsperiod har kostnaden per transplantation mi

ABSTRACT. Serum concentrations of creatinine and of the three low molecular weight (LMW) proteins cystatin C, factor D of the complement system and β2‐microglobulin were measured in 135 consecutive patients, whose glomerular filtration rates (GFR) were determined by Cr‐EDTA. In the total patient series, the reciprocals of S‐creatinine and S‐cystatin C were numerically and, in males, significantly

ALTHOUGH the total incidence of cerebral hemorrhage is high, comparatively few reports concerning the familial occurrence of this disease have been published.1,2 In 1935 Arnason described 10 families with a high incidence of cerebral hemorrhage and concluded that a hereditary form of the disease was present in these families.3 Further clinicopathological investigations of the disease revealed an a