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The challenge of managing radical innovation is partly about dealing with higher levels of uncertainty as organisations seek to extend their exploration into new technological and market spaces. Innovation management routines for dealing with this differ from those around incremental innovation — the well-established exploit/explore dilemma. But it can be argued that there is a second challenge as
NuoA is a small membrane spanning subunit of respiratory chain NADH:quinone oxidoreductase (complex I). Unlike the other complex I core protein subunits, the NuoA protein has no known homologue in other enzyme systems. The transmembrane orientation of NuoA cannot be unambiguously predicted, due to the small size of the polypeptide and the varying distribution of charged amino acid residues in NuoA
Saccharomyces cerevisiae alcohol dehydrogenases responsible for NADH-, and NADPH-specific reduction of the furaldehydes 5-hydroxymethyl-furfural (HMF) and furfural have previously been identified. In the present study, strains overexpressing the corresponding genes (mut-ADH1 and ADH6), together with a control strain, were compared in defined medium for anaerobic fermentation of glucose in the pres
The indoor climate in buildings has changed in the last decade due to more efficient climatic systems, floor heating systems and larger open floor areas with more natural light. All this has induced increasing ranges of relative humidity between different seasons. Also with decreasing relative humidity (in the winter 30-50% RH, in the summer 70-90% RH), floor-heating systems increase the temper
Following a royal act, a new academic discipline, Phonetics, was officially given birth in 1947. However, it was not until November 1950 that, at Lund University, Bertil Malmberg was appointed to the first Chair of Phonetics in Sweden. Four Scandinavian experts were chosen to evaluate Malmberg’s scientific competence. The peers produced four evaluations, which constitute the central corpus for th
We present the first multi-wavelength follow-up observations of two candidate gravitational-wave (GW) transient events recorded by LIGO and Virgo in their 2009-2010 science run. The events were selected with low latency by the network of GW detectors (within less than 10 minutes) and their candidate sky locations were observed by the Swift observatory (within 12 hr). Image transient detection was
The oxidation of the Pd(110) surface has been studied from ultrahigh vacuum up to atmospherical pressures by combining scanning tunneling microscopy, low-energy electron diffraction and high-resolution core-level spectroscopy with in situ surface x-ray diffraction, and density-functional theory calculations. Under in situ conditions, we observe a c(2x4) structure which transforms via the formation
In this review, I will present an overview of the development of the field of scatter hoarding studies. Scatter hoarding is a conspicuous behaviour and it has been observed by humans for a long time. Apart from an exceptional experimental study already published in 1720, it started with observational field studies of scatter hoarding birds in the 1940s. Driven by a general interest in birds, sever
Background High-resolution genomic microarrays enable simultaneous detection of copy-number aberrations such as the known recurrent aberrations in chronic lymphocytic leukemia [del(11q), del(13q), del(17p) and trisomy 12], and copy-number neutral loss of heterozygosity. Moreover, comparison of genomic profiles from sequential patients' samples allows detection of clonal evolution. Design and Metho
BACKGROUND: Viral gene therapy of malignant brain tumors has been restricted by the limited vector distribution within the tumors. Multipotent mesenchymal stromal cells (MSCs) and other precursor cells have shown tropism for gliomas, and these cells are currently being explored as potential vehicles for gene delivery in glioma gene therapy. OBJECTIVE: To investigate MSC migration in detail after i
This paper evaluates to what extent policy-makers have been able to promote the creation and consolidation of comprehensive research groups that contribute to the implementation of a successful innovation system. Malmquist productivity indices are applied in the case of the Spanish Food Technology Program, finding that a large size and a comprehensive multi-dimensional research output are the key
Med en s.k. Pressure Plate utrustning kan porstukturen hos porösa material undersökas. För grovporösa material, t.ex. olika jordarter, kan även kapillära stighöjden -”sugförmågan”- och kornstorleken bestämmas på ett enkelt sätt. Metoden går ut på att man gradvis pressar ut vatten ur ett vattenmättat prov genom att utsätta detta för stegvis ökat tryck. Det finns ett enkelt samband -Laplace´s lag- m
The impossibility results of Bovens and Hartmann (2003) and Olsson (2005) call into question the strength of the connection between coherence and truth. As part of the inquiry into this alleged link, I define a notion of degree of truth-conduciveness, relevant for measuring the usefulness of coherence measures as rules-of-thumb for assigning probabilities in situations of partial knowledge. I use
Inter-firm job switching of workers is a much cited but seldom measured source of the productivity advantages of spatial employment density. It has been advanced as a conduit for localized knowledge flows as well as labor market matching efficiency. Using a matched employer-employee dataset for Sweden, we estimate the influence spatial employment density has on the probability of inter-firm job sw
