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The pH-regulated Antigen 1 of Candida albicans Binds the Human Complement Inhibitor C4b-binding Protein and Mediates Fungal Complement Evasion

Candida albicans binds and utilizes human complement inhibitors, such as C4b-binding protein (C4BP), Factor H, and FHL-1 for immune evasion. Here, we identify Candida pH-regulated antigen 1 (Pra1) as the first fungal C4BP-binding protein. Recombinant Pra1 binds C4BP, as shown by ELISA and isothermal titration calorimetry, and the Pra1-C4BP interaction is ionic in nature. The Pra1 binding domains w

Fibromodulin Regulates Collagen Fibrillogenesis During Peripheral Corneal Development

Fibromodulin regulates collagen fibrillogenesis, but its existence/role(s) in the cornea is controversial. We hypothesize that fibromodulin regulates fibrillogenesis during postnatal development of the anterior eye. Fibromodulin is weakly expressed in the limbus at post-natal day (P) 4, increases and extends into the central cornea at P14, becomes restricted to the limbus at P30, and decreases at

Analgetic effects of non-thermal GSM-1900 radiofrequency electromagnetic fields in the land snail Helix pomatia

Purpose : To investigate whether mobile phone radiation might affect snail nociception, employing radiofrequency (RF) electromagnetic fields (EMF) which, to our knowledge, have hitherto not been studied in a snail model. Exposure to extremely low frequency (ELF) magnetic fields has however been shown to significantly affect nociceptive responses. Materials and methods : In the present study, we ex

The mediatized Zlatan: The immigrant’s path from provincial otherness to national identity and to a Western literary space

In this article the mediatisation of Zlatan Ibrahimovic's autobiography, written by the journalist David Lagercrantz, is investigated through the reception of the book as well as of other media formats in which it was made public. A main point made is that the processes of mediatisation is a main factor in creating a literary trademark and bestseller. The footballer's mythic life story, as express

ATLAS High-Level Trigger, Data Acquisition and Controls Technical Design Report

This Technical Design Report (TDR) for the High-level Trigger (HLT), Data Acquisition (DAQ) and Controls of the ATLAS experiment builds on the earlier documents published on these systems: Trigger Performance Status Report, DAQ, EF, LVL2 and DCS Technical Progress Report, and High-Level Triggers, DAQ and DCS Technical Proposal. Much background and preparatory work relevant to this TDR is reference

Structural Optimization of Multibody Systems

Flexible multibody dynamics (FMD) has found many applications in control, analysis and design of mechanical systems. FMD together with the theory of structural optimization can be used for designing multibody systems with bodies which are lighter, but stronger. Topology optimization of static structures is an active research topic in structural mechanics. However, the extension to the dynamic case

Gene Regulatory Networks: Dynamics and Stability

Popular Abstract in Swedish Alla levande varelser består av celler. En cell innehåller ett stort antal kemiska föreningar, och särskilt viktiga är proteiner och DNA. Proteiner utför många livsnödvändiga kemiska reaktioner, och DNA består av gener som beskriver hur dessa proteiner konstrueras. En gen kan vara uttryckt, så att det protein den beskriver - kodar för - tillverkas, men den kan också varLife as we know it is based on cells that use proteins and RNA to carry out metabolism, self-replication, and other essential tasks. The genes that code for these molecules are encoded in DNA, and through the processes of transcription and translation the cell expresses its genes. Some proteins are transcription factors that regulate the transcription rate of genes, so genes interact and form a ge

Mannen i ledet. Takt och otakt i värnpliktens skugga

Popular Abstract in Swedish Från början användes uttrycket "mannen i ledet" bara om meniga soldater, men det är också ett bildligt uttryck med innebörden gemene man, gräsrot, medlem på fältet/gräsrotsnivå/verkstadsgolvet. Den här avhandlingen handlar om unga män som under mitten av 1990-talet gjorde lumpen på ett pjäskompani vid Wendes artilleriregemente i skånska Hässleholm. ”Pjäs” betyder kanoneThis dissertation deals with young men who in the mid 1990s made their military service at a cannon company at Wende’s artillery regiment in the scanian town Hässleholm. ”Cannon” refers not only to cannons, but also to haubitses, grenade-throwers and other heavy arms. The focus, however, is on cultural and social aspects of everyday military service. What does actually happen in the encounter betw