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One of the most promising and novel strategies to interfere with neurological disease processes is gene therapy using recombinant adeno-associated viral (rAAV) vectors. Such a rAAV-based gene delivery approach is rapidly advancing towards clinical trials. In this regard, neuropeptide Y (NPY) gene transduction into the brain tissue has attracted particular interest due to its potential to regulate
Popular Abstract in Swedish Cancer i levern kan vara av två typer - antingen kan den ha sitt ursprung från levern och kallas primär levercancer eller också är den en spridning av tumör till levern från en annan plats i kroppen, s k dottersvulst eller metastas. Idag är kirurgi av tumörer i levern förstahandsbehandling, men tyvärr är det bara 1/10 patienter som har tumör i levern som kan bli aktuellLocal treatment of a tumour is of interest from a number of perspectives. It is focused on reducing the tumour volume with minimal trauma, inducing tumour immunity and is a potential component of a combination therapy against tumours. Interstitial laser thermotherapy (ILT) has turned out to be a method well suited for selective local destruction of malignant tumours. This thesis is based on an exp
Sedan år 2003 har kontinuerlig provtagning skett i Skillebyån inom ramen för recipientkontrollprogrammet Skillebyån som bedrivs av Stiftelsen Biodynamiska Forskningsinstitutet med stöd från Södertälje kommun, miljökontoret. Resultaten bekräftar tidigare undersökningsresultat och indikerar en fortsatt hög närsaltbelastning i ån. Resultaten baseras på mätning av vattenföring och närsalthalterna i ån
Construction of the MAX IV facility started in 2010 and commissioning is expected to begin in 2014. Once com- pleted, the facility will include two storage rings for the production of synchrotron radiation. The 3 GeV ring will house insertion devices for the production of x-rays, while the 1.5 GeV ring will serve UV and IR users. Recently, the lattice and optics of the 1.5 GeV storage ring have be
The Energy using products (EuP) directive proposed by the European Commission is often referred to as "the first Integrated Product Policy (IPP) directive". The main purpose of the directive is to ensure the free movement of EuP in the internal market as well as to improve the environmental performance of products throughout their life cycle. Product groups likely to be addressed through the direc
Popular Abstract in Swedish Effektiv sökning och sortering är byggstenar som används vid nästan all algoritmdesign. Sökrutiner och sorteringrutiner implementeras ofta slentrianmässigt med hjälp av algoritmer som bygger på parvisa jämförelser mellan element. I denna avhandling argumenterar vi för att algoritmer som också utnyttjar elementens interna struktur är överlägsna i många avseenden, både prEfficient sorting and searching are corner-stones in algorithm design. In computer science it has become a deep-rooted habit to use comparison-based methods to solve these problems. In this thesis we argue that radix sorting and searching algorithms are superior in many respects, both practical and theoretical. They are often remarkably simple and many, if not most, sorting and searching problems
The problem of burst losses in OBS networks has an impact on the service quality perceived by end users. In order to guarantee certain level of Service Quality (QoS) in terms of burst losses, wavelength resources have to be dimensioned properly. In this paper, we address the problem of the Virtual Topology (VT) design that concerns the establishment of explicit routing paths and the allocation of
I denna uppsats gör jag två saker. För det första ger jag en kortfattad beskrivning över kasussammanfallet i fornsvenska. För det andra diskuterar jag orsakerna till kasussammanfallet. Jag identifierar två viktiga tidsperioder då kasussystemet förändras. Den första inträffar kring 1300 och den andra kring 1450, åtminstone i Mälardalen. Jag kallar den första för Lilla katastrofen och den andra för
This textbook studies the 3 main types of coded modulation: trellis-coded modulation (TCM), continuous-phase modulation (CPM) codes, and linear modulation codes like those that arise from filtering and intersymbol interference. In 2 final chapters, code-division multiple-access receivers are discussed. The book begins with a review of coding, modulation and information theory.
In this paper, we propose to perform remote laser-induced fluorescence imaging for assessment of cultural heritage. The experiments are performed using the lidar system consist of frequency-tripled Nd:YAG laser at 355 nm with a spot size of ~4 cm diameter and the signal is collected using a coaxial 40-cm-diameter Newtonian telescope. The fluorescence light is focused into an optical fibre and guid
Abstract in Undetermined Packaging is of particular importance to retailers, since it can be considered an integral part of the product and the first point of contact with the brand (Rundh 2005). Over 73% of interviewed consumers rely on packaging to aid their purchasing decisions (Wells et al. 2007), and retailers are the ‘gatekeepers’ to the consumers (Dobson et al. 2003) via the retail stores,
This paper offers an analysis of a case of cooperation, and in particular cooperation problems, between independent performing arts organisations in the region of Skåne, Sweden. The cooperation in question flows from visions of the organisations, and linked regional commission to develop the infrastructure and networks of the independent performing arts in Skåne. The case gives evidence of the cha
Popular Abstract in Swedish Läpp- käk- gomspalt (LKG-spalt) förekommer hos cirka 200 nyfödda barn per år i Sverige. Det finns idag inte belägg för någon specifik faktor som orsakar LKG-spalten. Utan en adekvat habilitering som bl.a. innehåller kirurgi, tandreglering och talbehandling skulle barnen få funktionella och utseendemässiga problem som skulle leda till en försämrad livskvalite. UtvecklinBody dimensions of 2,936 newborns with cleft lip/palate (CLP) were compared with 2,031,140 singleton newborns between 1973 to 1992. The risk of cleft development was found to be associated with intra-uterine growth retardation - the more severe the cleft, the stronger the association. As digital photography is being increasingly applied in clinical medicine, we devised a computer software program
