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Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Cell replacement is a long-standing and realistic goal for the treatment of Parkinsonʼs disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. However, after transplantation, dopamine (DA) neurons are seen to be a minor component of grafts, and it has remained difficult to determine the identity of other cell types. Here, we report analysis by single-ce

Självskattad hälsa och förekomst av utmattningstecken bland Svenska skolledare: Tvärsnittsresultat från 2018 och 2019

I denna rapport redovisas delresultat från ett treårigt forskningsprojekt somfinansieras av AFA-försäkringar. Projektet heter ”Skolledares arbetsmiljö: Ettprojekt om organisatoriska förutsättningar, stressrelaterad psykisk ohälsa,personalrörlighet och förbättringspotential”. Projektet är ett tvärvetenskapligtsamarbete mellan Avdelningen för arbets- och miljömedicin (AMM) ochInstitutionen för psyko

Nya riktlinjer för kronisk pankreatit

Patients with chronic pancreatitis have an impaired quality of life and are at risk for several long-term complications. It is important to diagnose and treat these patients to minimize the effects of the disease. Clinical manifestations of chronic pancreatitis include a wide range of symptoms and patients are managed differenth between medical centers. In recent years, there have been improvement

VEGF synthesis and VEGF receptor 2 expression in patients with bronchiolitis obliterans syndrome after lung transplantation

OBJECTIVES: Chronic lung allograft dysfunction including Bronchiolitis obliterans syndrome (BOS) is common after lung transplantation. Histologically, BOS is recognized as fibrotic lesions with accumulated extracellular matrix (ECM) in small airways. Lung fibroblasts are major producers of ECM and vascular endothelial growth factor (VEGF). In this study we hypothesize that VEGF is involved in BOS

Behavioural responses to co-occurring threats of predation and ultraviolet radiation in Daphnia

Organisms in the wild are faced with multiple threats and a common response is a change in behaviour. To disentangle responses to several threats, we exposed two differently sized species of the freshwater invertebrate Daphnia to solar ultraviolet radiation (UVR) and predation from either moving pelagic or benthic ambush predators. Using an advanced nanotechnology-based method, we tracked the thre

Aktuell forskning i Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet

I denna text skisseras forskningen vid avdelningen för Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet. Avdelningen består idag av två doktorander, ett 10-tal forskare/lärare samt några mer löst tillknutna kollegor. Samarbete sker med flera interdisciplinära forskningsmiljöer på Lunds Universitet. Exempelvis är avdelningen idag representerad i två fakultetsöveI denna text skisseras forskningen vid avdelningen för Arbets- och organisationspsykologi vid Institutionen för Psykologi, Lunds Universitet. Avdelningen består idag av två doktorander, ett 10-tal forskare/lärare samt några mer löst tillknutna kollegor. Samarbete sker med flera interdisciplinära forskningsmiljöer på Lunds Universitet. Exempelvis är avdelningen idag representerad i två fakultetsöve

Rigid biobased polycarbonates with good processability based on a spirocyclic diol derived from citric acid

Introducing biobased polymers from renewable sources for use as high-performance thermoplastics with high demands on mechanical rigidity, transparency, thermal stability, as well as good processability, is a significant challenge. In the present work we have designed and prepared a rigid biobased bis-spirocylic diol by di-cycloketalization of a bicyclic diketone (cis-bicyclo[3.3.0]octane-3,7-dione

Agentic and visual effects of large-scale science research facilties

Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t

Compex: a cubic germanium detector

The Compex detector is an electrically cooled, composite germanium detector that uses four coaxial, cubic-shaped, single-encapsulated germanium crystals. This novel detector allows for new heights in photon detection efficiency in decay spectroscopy setups using box-shaped vacuum chambers. Its spectroscopic performance and detection efficiency is evaluated by means of source measurements. Motivate

Benchmarking the PreSPEC@GSI experiment for Coulex-multipolarimetry on the π(p3/2) → π(p1/2) spin-flip transition in 85Br

A first performance test of the Coulomb excitation multipolarimetry (Coulex-multipolarimetry) method is presented. It is based on a 85Br πp3/2 → πp1/2 spin-flip experiment performed as part of the PreSPEC-AGATA campaign at the GSI Helmholtzzentrum für Schwerionenforschung (GSI). Via determination of background levels around the expected 85Br excitations as well as measured 197Au excitations, an up

Physics opportunities with the Advanced Gamma Tracking Array: AGATA

New physics opportunities are opening up by the Advanced Gamma Tracking Array, AGATA, as it evolves to the full 4π instrument. AGATA is a high-resolution γ-ray spectrometer, solely built from highly segmented high-purity Ge detectors, capable of measuring γ rays from a few tens of keV to beyond 10 MeV, with unprecedented efficiency, excellent position resolution for individual γ-ray interactions,

Offspring per emergence hole at different attack densities in the Spruce Bark Beetle, Ips typographus (L.) (Coleoptera, Scolytidae)

Field and laboratory data from the spruce bark beetle, Ips typographus, showed that increased offspring production per unit bark area increased the average number that emerged per emergence hole. In the laboratory this offspring per hole ratio was investigated at different attack densities. Zahl der schlüpfenden Käfer pro Schlupfloch bei verschieden starkem Befall des Buchdruckers, Ips typographus

Attraction of bark beetles (Coleoptera : Scolytidae) to a pheromone trap - Experiment and mathematical models

The movement of bark beetles near an attractive pheromone source is described in terms of mathematical models of the diffusion type. To test the models, two release experiments involving 47,000 marked spruce bark beetles [Ips typographus (L.)] were performed. The attractive source was a pheromone trap, surrounded by eight concentric rings with eight passive trap stations on each ring. Captures wer

Improvement of Autism Symptoms After Comprehensive Intensive Early Interventions in Community Settings

BACKGROUND: Preschool children with autism in southern Sweden participated in a comprehensive Naturalistic Developmental Behavioral Intervention (NDBI) program. AIMS: To evaluate the ongoing NDBI program by comparing the pre- and postintervention outcomes in terms of improved autism symptom severity. METHOD: The improvement of Autism Diagnostic Observation Schedule (ADOS-R) test results between ba

Combining results from hip impingement and range of motion tests can increase diagnostic accuracy in patients with FAI syndrome

Purpose: Clinical examination is an important part in the diagnosis of femoroacetabular impingement (FAI) syndrome. However, knowledge on reliability and validity of clinical diagnostic tests is scarce. The aims were to evaluate the inter-rater agreement and diagnostic accuracy of clinical tests to detect patients with FAI syndrome. Methods: Eighty-one patients (49% women) were recruited. Two expe

Bone Mineral Density in Relation to Chronic Kidney Disease after Heart Transplantation : A Retrospective Single-center Study at Skåne University Hospital in Lund 1988-2016

Background. Our aim was to investigate the bone mineral density (BMD) evolution and incidence of osteoporosis in relation to chronic kidney disease (CKD) up to 10 years after heart transplantation (HT). Methods. A retrospective analysis was performed on 159 HT patients at Skåne University Hospital in Lund 1988-2016. Results. The median follow-up time was 6.1 years (interquartile range = 7.5 y). HT