Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder with poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated common genetic variants associated with DLB in a large European multisite sample. We performed a genome wide association study in Norwegian and European cohorts of 7

Based on all patients with tibial shaft fracture (n = 767) treated in the department of orthopedics in Malmö from 1955 to 1963, a retrospective cohort study was performed in 1990. Two hundred sixty-nine of the patients were still living in Malmö or had died in the city. Since all roentgenograms were available, all other fractures that this group of patients had sustained up to 1990 were included.

Noninvasive imaging methods are sought to objectively predict early response to therapy for high-grade glioma tumors. Quantitative metrics derived from diffusion-weighted imaging, such as apparent diffusion coefficient (ADC), have previously shown promise when used in combination with voxel-based analysis reflecting regional changes. The functional diffusion mapping (fDM) metric is hypothesized to

Purpose: Liquid biopsy has great potential to improve the management of brain tumor patients at high risk of surgery-associated complications. Here, the aim was to explore plasma extracellular vesicle (plEV) immunoprofiling as a tool for noninvasive diagnosis of glioma.Experimental Design: PlEV isolation and analysis were optimized using advanced mass spectrometry, nanoparticle tracking analysis,

Injuries to the spinal column and spinal cord are a major cause of disability, affecting predominately young, healthy individuals. The majority of the spinal injuries (60%) affect young healthy males between 15 and 35 years of age, with important socioeconomic consequences, and the costs of lifetime care and rehabilitation are extremely high. As the longevity of the general population increases, t

In patients with cutaneous openings, sinograph and fistulography are usually performed. Fistulae in the head/neck region and perineum are seldom life-threatening while enterocutaneous fistulae involving the small bowel can be a serious threat due to loss of fluid. Radiology contributes to the preoperative examination of these patients. Fistulography outlines communications to the gastrointestinal

Extracellular vesicles (EVs) have emerged as a rich source of biomarkers providing diagnostic and prognostic information in diseases such as cancer. Large-scale investigations into the contents of EVs in clinical cohorts are warranted, but a major obstacle is the lack of a rapid, reproducible, efficient, and low-cost methodology to enrich EVs. Here, we demonstrate the applicability of an automated

Despite some incremental policy shifts accounting for transport equity concerns, the norms within which transport systems worldwide currently function are still implicitly exclusive. Older people constitute a group which is particularly susceptible to issues within the transport system. However, this susceptibility is not evenly distributed, partly due to the considerable heterogeneity in circumst

Background: Long-term follow-up studies of interventions for children exposed to intimate partner violence are few, and the sustainability of their outcomes often remains unexplored and uncertain. Current research including follow-up assessment suggests that treatment gains may be maintained or continue post termination. In addition some children may show increased levels of symptoms. Objective: T

Purpose: To investigate the reasons for not proceeding to surgery in patients undergoing presurgical evaluation for epilepsy. Methods: A retrospective cohort study of 401 consecutive patients who were evaluated for but did not proceed to surgery for epilepsy between 1990 and 2016 at three Swedish epilepsy surgery centers was performed. Reasons for not proceeding to surgery were categorized as inco

The aim of this paper is to understand how the practice of package free shopping takes shape and is established. Taking a shopping-as-practice approach, and drawing on an ethnographic study of a Swedish ecological food store, this paper shows that to be able to successfully remove a key artefact - packaging - from the practice of shopping, the practice itself must be reinvented. Developing package

The Asian Summer Monsoons (ASM) represent the main source of precipitation in China and East Asia with about one third of the world population and a region of widespread civilizations. Identifying the temporal and spatial patterns (pathways) of these monsoonal events during the Late Holocene to today has been a matter of debate amongst the scientific community. Here we show that the distribution

Charged-particle spectra at midrapidity are measured in Pb–Pb collisions at the centre-of-mass energy per nucleon–nucleon pair s NN =5.02 TeV and presented in centrality classes ranging from most central (0–5%) to most peripheral (95–100%) collisions. Possible medium effects are quantified using the nuclear modification factor (R AA ) by comparing the measured spectra with those from proton–proton

Boken, som nu ges ut i en fjärde utvidgad och omarbetad upplaga, vänder sig till personer som är verksamma i industrin och kommer i kontakt med reglerteknik, som operatörer och olika kategorier av ingenjörer. Den är också lämplig att använda i skolor och utbildningar där reglerteknik ingår. Den nya upplagan har kompletterats med problem med lösningar, vilket gör den speciellt användbar för undervi

An observation of electroweak W ± Z production in association with two jets in proton–proton collisions is presented. The data collected by the ATLAS detector at the Large Hadron Collider in 2015 and 2016 at a centre-of-mass energy of s=13 TeV are used, corresponding to an integrated luminosity of 36.1fb −1 . Events containing three identified leptons, either electrons or muons, and two jets are s

Measures for the reduction of electric energy loads for lighting have predominantly focussed on increasing the efficiency of lighting systems. This efficiency has now reached levels unthinkable a few decades ago. However, a focus on mere efficiency is physically limiting, and does not necessarily ensure that the anticipated energy savings actually materialise. This paper presents a literature surv