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Formation of Archean continental crust constrained by boron isotopes

The continental crust grew and matured compositionally during the Palaeo- to Neoarchean through the addition of juvenile tonalite-trondhjemite-granodiorite (TTG) crust. This change has been linked to the start of global plate tectonics, following the general interpretation that TTGs represent ancient analogues of arc magmas. To test this, we analysed B concentrations and isotope compositions in 3.

AI Market Survey: Current State of AI in the Øresund Region Private Sector

The prevalence of Artificial Intelligence (AI) in the business landscape is indisputable. However, there are considerable gaps between the visionary ideas businesses communicate and their operational use of AI. The goal of this market survey is to identify companies currently working with AI in the Øresund Region - referred to as AI companies. The survey, conducted between June and September 2020,

Hjältar, skurkar och vanligt folk i berättelsen om det förlorade landet Sverige

This article aims to contribute to the knowledge about the success which nationalist parties have experienced during the latest decades in western societies. By a qualitative text analysis, using a case study method, a Facebook-group anonymously named Sverigesidan (The Swedish page), has been studied in order to discover patterns which can explain how nationalism can attract groups who obviously a

Experimental optimization of X-ray propagation-based phase contrast imaging geometry

Propagation-based phase contrast imaging (PB-PCI) with an X-ray lab source is a powerful technique to study low absorption samples, e.g. soft tissue or plastics, on the micrometer scale but is often limited by the low flux and coherence of the source. The setup geometry is essential for the performance since there is a trade-off where a short source distance yields a high contrast-to-noise ratio (

The Safety and Effectiveness of Flecainide in Children in the Current Era

This retrospective study sought to determine the safety and effectiveness of flecainide in children with normal hearts and those with congenital heart disease (CHD) or cardiomyopathy (CMO). Baseline and follow-up data at two pediatric cardiology sites were queried (2000–2015); a total of 175 patients (20 with CHD and two with CMO) receiving flecainide were assessed. When comparing patients with CH

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtai

Proteomic exploration of common pathophysiological pathways in diabetes and cardiovascular disease

AIMS: The epidemiological association between diabetes and cardiovascular disease is well established, but the pathophysiological link is complex and multifactorial. We investigated seven proteins, previously linked to incident diabetes mellitus, and their association with cardiovascular disease and mortality.METHODS AND RESULTS: Plasma samples from 1713 individuals from the Swedish population-bas

Using chemiluminescence imaging of cells (CLIC) for relative protein quantification

Cell physiology and cellular responses to external stimuli are partly controlled through protein binding, localization, and expression level. Thus, quantification of these processes is pivotal in understanding cellular biology and disease pathophysiology. However, it can be methodologically challenging. Immunofluorescence is a powerful technique, yet quantification by this method can be hampered b

Analysis of lignin monomers and oligomers in technical lignins using chromatography and mass spectrometry

Lignin is the most abundant aromatic biopolymer on earth and has the potential to play an important role in the transition from an oil-based refinery to a biorefinery-based industry. The isolation of lignin from the biomass can be achieved by several different technical processes and isolated lignins are referred to as technical lignins in literature. During the last decades, the conversion of tec

Theorizing Reactive Reflexivity : Lifestyle Displacement and Discordant Performances of Taste

Culturally oriented consumer research has predominantly been framed by two ideal types of reflexivity, which we characterize as existential and critical reflexiv-ity. Drawing from our research on divorced women who have been displaced from their domestically oriented, middle-class lifestyles, we develop an alternative con-ceptualization-reactive reflexivity-that highlights a different relationship

Increased intestinal permeability and gut dysbiosis in the R6/2 mouse model of Huntington’s disease

Huntington’s disease (HD) is a progressive, multifaceted neurodegenerative disease associated with weight loss and gut problems. Under healthy conditions, tight junction (TJ) proteins maintain the intestinal barrier integrity preventing bacterial translocation from the intestinal lumen to the systemic circulation. Reduction of TJs expression in Parkinson’s disease patients has been linked with inc

Niche-derived soluble DLK1 promotes glioma growth

Tumor cell behaviors associated with aggressive tumor growth such as proliferation, therapeutic resistance, and stem cell characteristics are regulated in part by soluble factors derived from the tumor microenvironment. Tumor-associated astrocytes represent a major component of the glioma tumor microenvironment, and astrocytes have an active role in maintenance of normal neural stem cells in the s

The validity of astrological predictions on marriage and divorce : a longitudinal analysis of Swedish register data

This paper examines astrology, a concept that is considered unscientific by broad segments of the population in the western world. Despite this, astrology remains for some an important source for advice regarding choices in a range of different matters, including career and relationships. The continuing popularity of astrology may at least partly be linked to an insufficient body of empirical rese