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Objective: To determine whether common variants in familial cerebral small vessel disease (SVD) genes confer risk of sporadic cerebral SVD. Methods: We meta-analyzed genotype data from individuals of European ancestry to determine associations of common single nucleotide polymorphisms (SNPs) in 6 familial cerebral SVD genes (COL4A1, COL4A2, NOTCH3, HTRA1, TREX1, and CECR1) with intracerebral hemor
Background: From earlier studies it is known that the APOE ϵ2/ϵ3/ϵ4 polymorphism modulates the concentrations of cerebrospinal fluid (CSF) beta-amyloid1-42 (Aβ42) in patients with cognitive decline due to Alzheimer's disease (AD), as well as in cognitively healthy controls. Here, in a large cohort consisting solely of cognitively healthy individuals, we aimed to evaluate how the effect of APOE on
This paper considers a housing market with price restrictions. On such market, price equilibrium may be excluded for certain preference profiles. However, the existence of a unique minimal rationing price equilibrium has previously been established on a general preference domain that contains “almost all” preference profiles. This type of equilibrium has been demonstrated to be an important ingred
A Good Practice is a practice that works well, produces good results, and is recommended as a model. MACVIA-ARIA Sentinel Network (MASK), the new Allergic Rhinitis and its Impact on Asthma (ARIA) initiative, is an example of a Good Practice focusing on the implementation of multi-sectoral care pathways using emerging technologies with real life data in rhinitis and asthma multi-morbidity. The Euro
In feminist research on sexual violence and victimization, the relationship between discourse and experience has often been at the forefront of intense debates. Poststructuralist scholars have emphasized that the discourses used to name sexual violence may in fact perpetuate the very problem they set out to describe, by freezing women into powerless positions of rapability. Others have likened thi
This volume presents cutting-edge research on integration and adaptation processes of second-generation immigrant adolescents in Spain that no doubt constitutes an important and timely contribution to the migration-integration debate. Principal findings of the Investigación Longitudinal de la Segunda Generación study indicate a comparatively smooth integration of second-generation immigrant adoles
This study investigates the 2007-2009 Fertile Crescent drought in the border region of Syria, Iraq and Turkey from an agricultural perspective using satellite based vegetation data combined with precipitation and land cover data. We look at the trends in vegetation productivity between 2001 and 2015, as well as the different politico-economic factors affecting land management leading up to the dro
Parkinsons sjukdom (PS) är den näst vanligaste neurodegenerativa sjukdomen efter Alzheimers sjukdom och drabbar över 1 % av personer över 65 år. Även om denna progressiva och försvagande sjukdom brukar anses vara en motorsjukdom, med symtom som stelhet, långsamma rörelser och vilotremor, så påverkas också icke-motoriska funktioner som sömn, kognition och mag-tarmfunktion. Dessa symtom förekommer vParkinson’s disease (PD) is the second most common neurodegenerative disorder and affects over 1% of people above the age of 65. This progressive and debilitating disease is usually thought of as a motor disease, with symptoms such as muscle rigidity, slowness of movement, and tremor at rest.PD can be familial, where a single inherited gene mutation causes the disease, but most cases of PD (90%) a
