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Biological systems are dynamic and display heterogeneity at all levels. Ubiquitous heterogeneity, here called for poikilosis, is an integral and important property of organisms and in molecules, systems and processes within them. Traditionally, heterogeneity in biology and experiments has been considered as unwanted noise, here poikilosis is shown to be the normal state. Acceptable variation range
Obesity is the main risk factor behind insulin resistance and type 2 diabetes. Still, the mechanism behind adipocyte dysfunction is not yet resolved. Recently, we reported that rapid actin remodeling correlates with adipose cell size changes after short-term overfeeding. Therefore, we hypothesized that the actin-driven myocardin-related transcription factor (MRTF-A) contributes to impaired mature
This study estimates the causal effect of paid vacation on health. Using register data on the universe of central government employees in Sweden, I exploit an age-based rule stipulated in the collective agreement covering these employees. I achieve identification by combining a regression discontinuity with a difference-in-differences design to control for time-invariant differences between consec
In QCD, we are used to describing the SU(3) color space in terms of a flow of color. At the algebra level, the Lorentz group consists of two copies of the (complexified) su(2) algebra, so one may anticipate that a similar way of thinking about the spacetime structure of scattering amplitudes should exist. In this article, we argue that this is indeed the case, and introduce the chirality-flow form
Background: No studies explore the career core of successful scientific leaders in nursing, a context where role models and career support would be desirable. To achieve a successful academic career, there is a need for an in-depth understanding of how successful scientific leaders in healthcare think in order to guide junior researchers through their early careers. Aim: To explore the main concer
To figure out the abnormal flow characteristics and thermal performance of supercritical fluids, some detailed information of supercritical pressure n-decane flowing in a horizontally round pipe is studied in terms of secondary flow induced by the huge density change or buoyancy force. According to an evaluation of turbulence models, the shear stress transport k-ω is suitable to execute the case o
Confinement during the COVID-19 pandemic is expected to have a serious and complex impact on the mental health of patients with an eating disorder (ED) and of patients with obesity. The present manuscript has the following aims: (1) to analyse the psychometric properties of the COVID Isolation Eating Scale (CIES), (2) to explore changes that occurred due to confinement in eating symptomatology; an
From an early age, humans intuitively expect physical objects to obey core principles, includingcontinuity (objects follow spatiotemporally continuous paths) and solidity (two solid objects cannotoccupy the same space at the same time). These 2 principles are sometimes viewed as deriving from asingle overarching “persistence” principle. Indeed, violations of solidity where one solid object seem-in
Using observational data to assess the treatment effects on outcomes of kidney transplantation relative to dialysis for patients on renal replacement therapy is challenging due to the non-random selection into treatment. This study applied the propensity score weighting approach in order to address the treatment selection bias of kidney transplantation on survival time compared with dialysis for p
AIM: While the scientific evidence in favour of negative pressure wound therapy (NPWT) dressings on sutured incisions in the prevention of surgical site infections (SSIs) has increased, the cost-effectiveness after vascular surgery has not been evaluated. The aim of this study was to evaluate the cost-effectiveness of NPWT compared to standard dressings for the prevention of SSIs after open inguin
The public unemployment insurance program in Sweden has retrenched in terms of its benefit generosity in the last three decades. As a response to this trend in which an ever-smaller proportion of the previous income of unemployed persons is compensated by public unemployment insurance benefit, complementary income insurance schemes provided by unions have expanded rapidly in the last 15 years and
Scholarship on media and politics presumes a ‘mediatization’ of politics over time, which overlooks the evolution of a mediatized public sphere that shaped people’s understandings of what actually constituted politics. This article investigates the public sphere to demonstrate how it created expectations for politicians and journalists within the process of the mediatization of politics. To unders
As a civil servant in the East India Company and witness to government expansion and reorganization in the mid-nineteenth century, John Stuart Mill developed an interest in civil service reform. In an essay supporting the 1854 Northcote-Trevelyan Report and his later political treatises, Mill argued for competitive civil service recruitment. These writings have been relatively neglected by Mill sc
Multicultural theory pays surprisingly little attention to the plurality of identity. In addition, there is still dissatisfaction with Will Kymlicka's distinction between polyethnic groups and national minorities and the rights they deserve, as well as continued criticism of liberal multiculturalism more broadly. I revisit this distinction based on Amartya Sen's recent effort to introduce the noti
5d iridium oxides are of huge interest due to the potential for new quantum states driven by strong spin-orbit coupling. The strontium iridate Sr_{2}IrO_{4} is particularly in the spotlight because of the so-called j_{eff}=1/2 state consisting of a quantum superposition of the three local t_{2g} orbitals with, in its simplest version, nearly equal populations, which stabilizes an unconventional Mo
Transfusion-related acute lung injury (TRALI) remains a leading cause of transfusionrelated deaths. In most cases, anti-leukocyte antibodies in the transfusion product trigger TRALI, but not all anti-leukocyte antibodies cause TRALI. It has been shown that the anti-major histocompatibility complex (MHC) class I antibody 34-1-2S (anti-H-2Kd) causes TRALI in BALB/c mice (MHC class I haplotype H-2Kd)
This paper reports on the spray structure of the biofuels, ethanol, and butanol generated by a multihole direct-injection spark-ignition injector, which is studied in a constant volume chamber. The spray shape and structure are analyzed using two-phase structured laser illumination planar imaging where both laser-induced fluorescence and Mie-scattering light are recorded simultaneously for the ext
