Popular Abstract in Swedish Idag har patienter med blodcancer (leukemi) eller genetiskt betingade blodsjukdomar (sickelcellanemi etc.) begränsad tillgång till behandlingar som effektivt och riskfritt botar sjukdomstillståndet. Detta arbete inkluderar forskningsresultat ämnade att bidra till utveckling av konceptuellt nya behandlingsmetoder för olika typer av blodsjukdomar. Ett fungerande blodsysteThere is a pressing need for compatible Hematopoietic Stem Cells (HSCs), in high quantities and of good clinical quality, to ensure optimal treatment for patients with various blood malignancies. Pluripotent Stem Cells (PSCs) have the potential to be a source for generating HSCs. The indefinite expansion capacity of PSCs, combined with the possibility of creating these cells from patient-specific

Background: Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles. Objectives: To determine respiratory tract deposition o

This article presents the notion of spatial justice as a way of considering the relationship between law and street art in a manner beyond the legal/illegal dichotomy. Through a series of empirical examples, it is demonstrated how street art literally takes a place already taken and imposes itself in an already appropriated urban public space. Street art thus ´redefines the space in contestation t

LuCuGaO4 has magnetic Cu2+ and diamagnetic Ga3+ ions distributed on a triangular bilayer and is suggested to undergo a spin glass transition at T-g similar to 0.4 K. Using mu SR (muon spin rotation) and neutron scattering measurements, we show that at low temperature the spins form a short range correlated state with spin fluctuations detectable over a wide range of timescales: at 0.05 K magnetic

The discovery of the key role of Toll-like receptors (TLRs) in initiating innate immune responses and modulating adaptive immunity has revolutionized our understanding of vertebrate defence against pathogens. Yet, despite their central role in pathogen recognition and defence initiation, there is little information on how variation in TLRs influences disease susceptibility in natural populations.

Simultaneous detection of multiple-gas species has for the first time (to our knowledge) been demonstrated by using a multimode diode-laser-based correlation spectroscopy (MDL-COSPEC) scheme. Concentration measurements of a mixture of CO2 and CO gas were performed by probing overlapping line spectra around 1.57 mu m using an MDL. Species identification and corresponding quantitive analysis were im

Waxing and waning ice sheets and changing sea levels have been interpreted from the Quaternary stratigraphic record at Leinstranda, Broggerhalvoya in NW Svalbard. We have identified seven high relative sea-level events, related to glacio-isostatic loading, and separated by at least four glacial events. To establish a chronology for the high sea-level events (interstadials and interglacials) and th

Objective: Lack of sensory feedback is a drawback in today's hand prostheses. We present here a non-invasive simple sensory feedback system, which provides the user of a prosthetic hand with sensory feedback on the arm stump. It is mediated by air in a closed loop system connecting silicone pads on the prosthetic hand with pads on the amputation stump. The silicone pads in a "tactile display" on

Immunological data show that type 2 diabetes (T2D) manifests autoimmune features. We wanted to test the association epidemiologically by assessing subsequent diagnosis of T2D following diagnosis of autoimmune disease (AId) and subsequent AId after T2D in the same individuals. Patients were identified from three Swedish health databases. A total of 32 different AId were included. Standardized incid

Besides traditional atmospheric frying, high pressure (super-atmospheric) frying might be an alternative approach to the frying of food products. In this study, convective heat transfer coefficient during atmospheric and high pressure frying was compared. For this purpose, a pressure cooker was modified to allow the immersion of a sample into frying oil under pressure and temperature measurement o

The last two decades have seen a noticeable increase in cognitive science studies that has changed the understanding of human thinking. Historians cannot ignore this any more. Cognitive history could be explained as the study of how humans in history used their cognitive abilities in order to understand the world around them and to orient themselves in it, but also how the world outside their bodi

Aim To study which eye-screening protocol prevails in Swedish maternity/neonatal wards, evaluate efficacy in a prospective study and compare results with earlier Swedish retrospective results. Methods Surveys were sent in 2006 to maternity/neonatal and women's health departments regarding screening policy. Response frequency was 96% (122/127). Data were derived from the Paediatric Cataract Registe

Salutogenesis focuses on how come people recover or stay well. The answer was described to be a Sense of Coherence (SOC). SOC is a global orientation which contributes to how flexible coping strategies are chosen. The SOC concept was operationalized in The Sense of Coherence Scale (SOC-29). The questionnaire address to what extent life is perceived as comprehensible, manageable, and meaningful. T

This work is underlain by broad-based expectations that policy interventions such as EU 2020 goals for renewable energy will continue to drive increased international trade in biomass for energy. This work focuses on where and how large volumes of biomass for bioenergy may be brought to the market in the short to medium term and sought insights in the following areas: • the manner in which demand

Climate warming in the Swedish sub-Arctic since 2000 has reached a level at which statistical analysis shows for the first time that current warming has exceeded that in the late 1930' s and early 1940' s, and has significantly crossed the 0 degrees C mean annual temperature threshold which causes many cryospheric and ecological impacts. The accelerating temperature increase trend has driven simil

Objectives: To perform a genome-wide association study (GWAS) using the Immunochip array in 3,420 cases of ischemic stroke and 6,821 controls, followed by a meta-analysis with data from more than 14,000 additional ischemic stroke cases. Methods: Using the Immunochip, we genotyped 3,420 ischemic stroke cases and 6,821 controls. After imputation we meta-analyzed the results with imputed GWAS data fr