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Background/AimOpioid overdose deaths have increased in Sweden and other developed countries in recent decades, despite increased treatment efforts and harm-reduction interventions. Further knowledge in this field is needed if this trend is to be reversed. Previous research suggests that mental health and patterns of prescription of opioids and other prescription drugs are associated with increased
Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The non-negativity constraint makes sense biologically as genes may either be expressed or not, but never show negative expression. We applied NMF to five different microarray data sets. We estimated the appropriat
Streptococcus pyogenes causes a multitude of local and systemic infections, the most common being pharyngitis in children. Recurrent pharyngeal infections are common and are thought to be due to the re-emergence of intracellular GAS upon completion of antibiotic treatment. The role of colonizing biofilm bacteria in this process is not fully clear. Here, live respiratory epithelial cells were inoc
Samtidigt som bilen är själva grunden för det sätt vi förflyttar oss i samhället, utgör bilismen den främsta orsaken till transportsektorns negativa miljö- och hälsoeffekter. Denna avhandling handlar om politiska försök att gå bortom bilen, mot en mer hållbar form av mobilitet. Hållbar mobilitet eller hållbara transporter, som är den mer använda termen i Sverige, har de senaste decennierna kommit Transport policies in Western Europe are increasingly framed in terms of sustainable mobility. This is a response to an urgent need to tackle adverse consequences of the transport system and implies changes in discourses related to transport. Exploring sustainable mobility is a fruitful way of studying discursive development in a policy field historically connected to priorities radically differen
Alveolar epithelial cells (AEC) have been implicated in pathological remodelling. We examined the capacity of AEC to produce extracellular matrix (ECM) and thereby directly contribute towards remodelling in chronic lung diseases. Cryopreserved type 2 AEC (AEC2) from healthy lungs and chronic obstructive pulmonary disease (COPD) afflicted lungs were cultured in decellularized healthy human lung sli
Nonlinear analysis of structures at high temperatures is studied. Both geometric and material nonlinearities are taken into account.Continuum mechanics relations are used to derive general finite element equations. An alternative formulation to Total Lagrangian (TL) and Updated Lagrangian (UL) formulations named Partially updated Lagrangian (PL) formulation i presented.An isotropic small strain co
In September 2020, the EU Commission published the New Pact on Migration and Asylum in order to offer ‘fresh start’ for EU migration law and policy. Complementary pathways for admission to EU territory were among the proposals set out in the Pact. This article takes stock of the different measures suggested by the Commission to create such complementary pathways. It suggests that the aim of creati
A range of third-sector organizations, among them diaconal actors, contributes actively to the welfare mix in the Nordic countries. The independence of these actors is in constant tension with the fact that the organizations are dependent on resources from the surrounding society. Norms and rules influence nonprofit organizations to adopt practices that change the organization, in the direction ofA range of third-sector organizations, among them diaconal actors, contributes actively to thewelfare mix in the Nordic countries. The independence of these actors is in constant tension with thefact that the organizations are dependent on resources from the surrounding society. Norms andrules influence nonprofit organizations to adopt practices that change the organization, in thedirection of an
Orthostatic intolerance and other autonomic dysfunction syndromes are emerging as distinct symptom clusters in Long Covid. Often accompanying these are common, multi-system constitutional features such as fatigue, malaise and skin rashes which can signify generalized immune dysregulation. At the same time, multiple autoantibodies are identified in both Covid-related autonomic disorders and non-Cov
Significant collaborations with research partners in China are seen in many Western countries. With increasing US-China geopolitical tensions, governments, research institutions, and individuals in established scientific systems are increasingly required to address a proliferating array of risks and challenges associated with collaboration with China. Academic researchers are only beginning to des
This is part one of a two-part series on the role of ethnology as a humanistic discipline, particularly its contribution to understanding the cultural impact of current medical practices and research. Ethnology describes itself as a science that takes the pulse of society. How this is carried out and what questions ethnology asks is the overarching theme throughout the two parts of the series. In
AIM: To study the association between within-person changes in patient-reported outcomes (PROMs) and wish for joint surgery during participation in a digital first-line intervention comprising exercise and education for knee/hip osteoarthritis (OA).METHODS: Retrospective observational registry study. Participants enrolled between 01/06/2018 and 30/10/2021 with follow-up data at 3 months (n=13,961)
