Filetype
For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that integrin activity and cytoskeletal dynamics are reciprocally linked, where actin-depe
In many social contexts, social influence seems to be inescapable: the behavior of others influences us to modify ours, and vice-versa. However, social psychology is full of examples of phenomena where individuals experience a discrepancy between their public behavior and their private opinion. This raises two central questions. First, how does an individual reason about the behavior of others and
The rising prevalences of type 2 diabetes and obesity constitute major threats to human health globally. Powerful social and economic factors influence the distribution of these diseases among and within populations. These factors act on a substrate of individual predisposition derived from the composite effects of inherited DNA variation and a range of environmental exposures experienced througho
Recent advances in cell sorting aim at the development of novel methods that are sensitive to various mechanical properties of cells. Microfluidic technologies have a great potential for cell sorting; however, the design of many micro-devices is based on theories developed for rigid spherical particles with size as a separation parameter. Clearly, most bioparticles are non-spherical and deformable
Underthrusting of Laurentia by the continental margin of Baltica during Caledonian orogeny resulted in the lateral emplacement of Iapetus Ocean-related terranes of the Upper Allochthon at least 500 km onto Baltica. The underlying Lower and Middle allochthons of the Baltoscandian margin mostly comprise Cryogenian, Ediacaran and Cambro-Silurian sedimentary successions; basement to these formations a
Allotwinning, the ordered intergrowth of two different structures may often be seen as a special case of OD-structures. The same structural ambiguity that allows for locally identical but globally different components of an allotwin may also allow the formation of an OD structure. When this is the case, the components of the allotwin often correspond to the MDO-structures of OD theory. Starting fr
The importance of the subchondral bone plate of the acetabulum when preparing the pelvis for a cemented acetabular cup during total hip arthroplasty (THA) has been investigated using finite element analysis. The effect of retaining or removing the subchondral bone plate and the use of anchoring holes are compared. Loading was applied via both hip joint contact force and the activity of up to 22 mu
Disinhibition is an important symptom in neurodegenerative diseases. However, the clinico- anatomical underpinnings remain controversial. We explored the anatomical correlates of disinhibition in neurodegenerative disease using the perspective of grey and white matter imaging. Disinhibition was assessed with a neuropsychological test and a caregiver information- based clinical rating scale in 21 p
Background: The intestinal barrier is immature in newborn mammals allowing for transfer of bioactive macromolecules, e.g. protecting antibodies, from mother's milk to the blood circulation and in neonatal rodents lasts until weaning. This passage involves the neonatal-Fc-receptor (FcRn) binding IgG in the proximal and highly endocytic vacuolated enterocytes in the distal immature small intestine (
Reinforced mortar samples were exposed in humidity chambers with different relative humidity or exposed in cyclic moisture conditions. The rebars were in an “as received” condition meaning that the preexisting oxide scale were intact. The lowest chloride concentration that initiated corrosion was 1% Cl− by mass of cement, corrosion was then observed for samples exposed at 97% relative humidity. It
Mycobacterium bovis bacilli Calmette-Guerin (BCG) is used as a benchmark to compare the immunogenicity of new vaccines against tuberculosis. This live vaccine is administered intradermal, but several new studies show that changing the route to mucosal immunisation represents an improved strategy. We analysed the immunomodulatory functions of BCG on human neutrophils and primary airway epithelial c
Background: Concerns about falling, a construct related to fear of falling, is increased in people with Parkinson's disease (PD) and is recognized as a barrier for exercise, negatively affecting health-related quality of life and participation. Aim: To investigate modifiable factors associated with concerns about falling in elderly with mild-to-moderate PD. Methods: Eighty-nine elderly (39 females
Detta är en efterlängtad bok som bidrar till utveckling av forskarhandledares kompetens och ger ett fördjupat perspektiv på doktoranders lärande. Med förankring i aktuell forskning behandlar författarna forskarutbildningens organisation, handledarens professionella praktik, doktorandens lärande samt utbildningens kvalitetssystem. Kopplingen mellan teori och praktik utgör en röd tråd genom boken.
Background: Peptidyl-prolyl isomerases (PPIases) catalyze cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding. SlyD is a two-domain enzyme containing both a PPIase FK506-binding protein (FKBP) domain and an insert-in-flap (IF) chaperone domain. To date, the interactions of these domains with unfolded proteins have remained rather obscure, with structu
Jesper Kristiansen1, Maria Kristine Friborg1, Lars Brandt2, Nanna Eller3, David Glasscock4, Anders Daldorph Nielsen2, Roger Persson5, Aniella Besèr6, Marie Åsberg6
Objective: To examine the efficacy of fixed-frequency Békésy’s home audiometry to assess hearing fluctuation and treatment outcomes in patients with subjectively fluctuating hearing loss. Design: SMAPH, a software audiometry program for Windows, was installed and calibrated on laptop computers. Békésy’s audiometry was carried out daily in the patients’ homes, using sound-attenuating earphones. Stu
We present a minimal solver for a special kind of homography arising in applications with planar camera motion (e.g. mobile robotics applications). Since the camera motion we consider only has five degrees of freedom, an explicit parametrisation allows us to reduce the required number of point correspondences to 2.5. Using fewer point correspondences is beneficial when used together with RANSAC, b
