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Anorexia nervosa and autism : a prospective twin cohort study
Background: Anorexia nervosa (AN) and autism spectrum disorder (ASD) may be phenotypically and etiologically linked. However, due to the absence of prospective studies, it remains unclear whether the elevation of autistic traits in AN is evident in early childhood. Here, we prospectively investigated autistic traits before and after the first diagnosis of AN. Methods: In a population-based sample
Mechanistic Investigation into Dynamic Function of Third-Component Incorporated in Ternary Near-Infrared Nonfullerene Organic Solar Cells
Organic solar cells (OSCs) consisting of an ultralow-bandgap nonfullerene acceptor (NFA) with an optical absorption edge that extends to the near-infrared (NIR) region are of vital interest to semitransparent and tandem devices. However, huge energy-loss related to inefficient charge dissociation hinders their further development. The critical issues of charge separation as exemplified in NIR-NFA
Cost-effectiveness of pneumococcal vaccination for elderly in Sweden
Introduction: The aim was to assess cost-effectiveness of including pneumococcal vaccination for elderly in a national vaccination programme in Sweden, comparing health-effects and costs of pneumococcal related diseases with a vaccination programme versus no vaccination. Method: We used a single-cohort deterministic decision-tree model to simulate the current burden of pneumococcal disease in Swed
Effects of milk proteins and posttranslational modifications on noncoagulating milk from Swedish Red dairy cattle
Milk that does not coagulate after rennet addition, also called noncoagulating (NC) milk, is unwanted in cheese production due to prolonged processing time. Amounts of whey and casein proteins, genetic variants, as well as posttranslational modifications (PTM) of proteins are all contributing factors in rennet-induced coagulation of milk. In this study, we conducted a wide-ranging investigation of
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The largely covered Middle Ordovician succession in the classic geological Röstånga area in northwestern Scania has not been studied for some 80 years. A new drill core through a succession ranging from the lower–middle Darriwilian to the lower Sandbian has provided a unique opportunity to investigate the graptolite biostratigraphy and the δ13Corg chemostratigraphy, and clarify their stratigraphic
Meanings of Theory : Clarifying Theory through Typification
Developing and evaluating scientific knowledge and its value requires a clear – or at least not too unclear – understanding of what ‘theory’ means. We argue that common definitions of theory are too restrictive, as they do not acknowledge the existence of multiple kinds of scientific knowledge, but largely recognize only one kind as ‘theory’, namely explanatory knowledge. We elaborate a typology t
It is not my job : exploring the disconnect between corporate security policies and actual security practices in SMEs
Purpose: This paper aims to present empirical results exemplifying challenges related to information security faced by small and medium enterprises (SMEs). It uses guidelines based on work system theory (WST) to frame the results, thereby illustrating why the mere existence of corporate security policies or general security training often is insufficient for establishing and maintaining informatio
Communication management
Giant Cell Arteritis versus Takayasu Arteritis: An Update
Giant cell arteritis (GCA) and Takayasu Arteritis (TAK) are two systemic granulomatous vasculitides affecting medium- and large-sized arteries. Similarities in GCA and TAK regarding the clinical presentation, the systemic inflammatory response and the distribution of the arterial lesions, have triggered a debate over the last decade about whether GCA and TAK represent two different diseases, or ar
”Varför denna rädsla för att utvärdera?”
Finns det något annat politikområde än narkotikapolitiken där en uttalad försämring tas till intäkt för att politiken har varit verkningsfull? Den frågan ställer debattörer i en slutreplik.
Recombinant alpha-1-microglobulin is a potential kidney protector in 177Lu-octreotate treatment of neuroendocrine tumors
Treatment of neuroendocrine tumors with 177Lu-octreotate results in prolonged survival and improved quality of life for the patient. However, the treatment is today limited by side effects on kidney and bone marrow, and complete tumor remission is rarely seen. A possible way to minimize dose-limiting toxicity and to optimize this treatment method is to use radioprotectors in conjunction with radio
Brevväxling som pedagogisk metod
Kort beskrivning av hur brevväxling används som pedagogisk metod inom utbildningen på avancerad nivå i Litterär gestaltning ("Författarskolan"), LU.
LGR5 in breast cancer and ductal carcinoma in situ : a diagnostic and prognostic biomarker and a therapeutic target
BACKGROUND: Novel biomarkers are required to discern between breast tumors that should be targeted for treatment from those that would never become clinically apparent and/or life threatening for patients. Moreover, therapeutics that specifically target breast cancer (BC) cells with tumor-initiating capacity to prevent recurrence are an unmet need. We investigated the clinical importance of LGR5 i
Court of Justice of the European Union (Grand Chamber) Grupo Norte Facility SA v Angel Manuel Moreira Gómez, Case C-574/16
Court of Justice of the European Union (Grand Chamber) Sindicatul Familia Constanţa and Others v Direcţia Generală de Asistenţă Socială şi Protecţia Copilului Constanţa, Case C-147/17
Residual positioning errors and uncertainties for pediatric craniospinal irradiation and the impact of image guidance
Background: Optimal alignment is of utmost importance when treating pediatric patients with craniospinal irradiation (CSI), especially with regards to field junctions and multiple isocenters and techniques applying high dose gradients. Here, we investigated the setup errors and uncertainties for pediatric CSI using different setup verification protocols. Methods: A total of 38 pediatric patients t
Generalized Moment Correction for Long-Ranged Electrostatics
Describing long-ranged electrostatics using short-ranged pair potentials is appealing because the computational complexity scales linearly with the number of particles. The foundation of the approach presented here is to mimic the long-ranged medium response by cancelling electric multipoles within a small cutoff sphere. We propose a rigorous and formally exact new method that cancels up to infini
Influence of Several Compounds and Drugs on the Renal Uptake of Radiolabeled Affibody Molecules
Affibody molecules are the most studied class of engineered scaffold proteins (ESPs) in radionuclide molecular imaging. Attempts to use affibody molecules directly labelled with radiometals for targeted radionuclide therapy were hampered by the high uptake and retention of radioactivity in kidneys. Several promising strategies have been implemented to circumvent this problem. Here, we investigated
Snapshot 3D reconstruction of liquid surfaces
In contrast to static objects, liquid structures such as drops, blobs, as well as waves and ripples on water surfaces are challenging to image in 3D due to two main reasons: First, the transient nature of those phenomena requires snapshot imaging that is fast enough to freeze the motion of the liquid. Second, the transparency of liquids and the specular reflections from their surfaces induce compl