Parkinson's disease (PD) is characterized by the loss of the dopaminergic nigrostriatal pathway which has led to the successful development of drug therapies that replace or stimulate this network pharmacologically. Although these drugs work well in the early stages of the disease, over time they produce side effects along with less consistent clinical benefits to the person with Parkinson's (PwP)

Targeted delivery of α-synuclein using AAV vectors has over the two decades since its introduction developed into a versatile tool for modeling different aspects of synucleinopathy, mimicking those seen in Parkinson's disease and related Lewy body disorders. The viral vector approach to disease modeling is attractive in that the expression of α-synuclein, wild-type or mutated, can be confined to d

Posttraumatic stress disorder (PTSD) is a chronic psychiatric condition that follows exposure to a traumatic stressor. Though previous in vivo proton (1H) MRS) research conducted at 4 T or lower has identified alterations in glutamate metabolism associated with PTSD predisposition and/or progression, no prior investigations have been conducted at higher field strength. In addition, earlier studies

The overarching aim of the book is to provide the first comprehensive account of Sweden’s feminist foreign policy and its dissemination through digital diplomacy. In contrast to other scholarly studies of digital diplomacy that tend to view it as a technological and apolitical device for online diplomatic communication, this book examines the specific political dynamics of digital diplomacy. It po

Marknadsanalys handlar i fastighetssammanhang i grunden om att undersöka fastighetsmarknaden i syfte att förstå hur fastigheter prissätts på marknaden. Det i sin tur handlar både om att förstå hur fastigheter i allmänhet prissätts och hur specifika fastigheter prissätts. Det förstnämnda handlar om prisnivån på fastighetsmarknaden och det andra om priset på en specifik fastighet. Det här kapitlet h

There has been widespread debate about whether the way in which we measure economic activity is fit for purpose in the twenty-first century. One aspect of this debate is to move away from measuring a nation's income (GDP) towards monitoring a nation's assets (their inclusive wealth), as a better indicator of sustainable economic development. We provide the first critical comparison of the approach

A study of 25 pupils working in groups with a digital mathematics game on table tabletswas conducted in a Swedish first school year class. The pupils’ communications and actions whensolving problems, with no teacher interference, were studied to contribute knowledge about howgroups of pupils engage in digital games. Data sets, in the form of transcripts from video recordings ofpupils working in gr

Vårt team av kliniska forskare i Lund, Sverige, fann att elektromagnetisk strålning, som den som används i mobil kommunikation, även vid låga effektvärden, gör att användarnas blodalbumin läcker genom blod-hjärnbarriären "BBB" in i hjärnvävnaden .BBB är tänkt att skydda hjärnan mot oönskade och giftiga molekyler som potentiellt finns i blodet för att överföras till hjärnvävnaden. Men vårt team i L

This paper aims at formulating and analysing the development of 15 students in their creations of mental representations of limits of functions during a basic mathematics course at a Swedish university. Their concept images are sought via questionnaires and interviews. How do students respond to limits of functions? The data indicate that some students have incoherent representations, but they do

The main aim of this article is to discuss the attitudes to mathematics of students taking a basic mathematics course at a Swedish university, and to explore possible links between how well such students manage to solve tasks about limits of functions and their attitudes. Two groups, each of about a hundred students, were investigated using questionnaires, field notes and interviews. From the resu

Students at a Swedish university were subjects in a study about learning limits of functions. The students' perceptions were investigated in terms of traces of concept images through interviews and problem solving. The results imply that most students' foundations were not sufficiently strong for them to understand the concept of limit well enough to be able to form coherent concept images. The tr

BACKGROUND: Cell blocks (CBs) are widely used for biomarker analyses such as immunostaining. Although immunohistochemistry on formalin-fixed paraffin-embedded tissues is standardized, there are multiple preparation methods and fixatives for cytology. Our objective was to investigate the effect of different common fixatives on the immunoreactivity of pleural effusion CBs with metastatic lung adenoc

Biomass is often viewed as a primitive source of energy that needs to be modernized. However, itis unlikely that preferred modern energy sources will displace traditional biomass-based energyin the near term, especially in rural Africa and southeast Asia (FAO 2017). Demand for sustainablysourced biomass is likely to increase as the world moves away from fossil fuel dependence andtransitions to sus

Populärvetenskaplig sammanfattningIntroduktionI dagens digitala era har sociala medier och internet blivit centrala plattformar för nyhetsförmedling och offentlig debatt. Denna utveckling har främjat snabbare informationsspridning och ökat engagemang i samhällsfrågor. Samtidigt har det också medfört en ökning av negativa påtryckningar i form av trakasserier, hat och allmänt ogillande, särskilt rikIntegrating socio-legal analysis and working life science, this compilation thesis aims to enhance the understanding of how the evolving digital landscape—particularly the rise of online harassment—influences journalism and its potential to foster healthy public discourse. Additionally, the thesis seeks to advance the field of socio-legal studies by examining the interplay between digital transfor

Quantification of in vivo proton magnetic resonance spectra (1H-MRS) still commonly involves evaluation of exclusively the real part of acquired spectral signals, but ignoring the information contained in the imaginary component may limit precise identification of individual metabolite contributions. Here, we assess quantification precision relative to SNR and noise correlation for both real and c