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A novel respirometer for online detection of metabolites in aquaculture research: Evaluation and first applications

In this study we describe a novel flow-through respirometer with automated and semi-continuous detection of key water variables. The recirculating aquaculture system was designed to house aquatic organisms in culture-like conditions and allow long-term, high-precision measurements. Nine respirometry tanks (250 L in volume each) housed animals, and a tenth (without animals) acted as a reference tan

Bacterial glycosidases in pathogenesis and glycoengineering.

ABSTRACT Glycosylation is a common post-translational protein modification and many key proteins of the immune system are glycosylated. As the true experts of our immune system, pathogenic bacteria produce enzymes that can modify the carbohydrates (glycans) of the defense mechanisms in order to favor bacterial survival and persistence. At the intersection between bacterial pathogenesis and glycobi

Exploring the origins of structure-oxygen affinity relationship of human haemoglobin allosteric effector

A data set comprising 27 myo-inositol derivatives based on tetrakisphosphates and bispyrophosphates were used in the development of quantitative structure-activity relationship model for investigating its allosteric effector property against human haemoglobin (Hb). Three-dimensional structures of the investigated compounds were subjected to geometry optimisations at the density functional theory l

Statistical and Knowledge Supported Visualization of Multivariate data

In the present work we have selected a collection of statistical and mathematical tools useful for the exploration of multivariate data and we present them in a form that is meant to be particularly accessible to a classically trained mathematician. We give self contained and streamlined introductions to principal component analysis, multidimensional scaling and statistical hypothesis testing. Wit

Prediction of Parasitic Components in an Automotive Environment

The amount of electrical loads and the complexity of the electric system in a vehicle is increasing at the same time as the allowed development time is decreasing. Possibilities to predict the electromagnetic behaviour is therefore of great importance. This paper addresses the problems of low frequency electromagnetic crosstalk between cables in a harness. Analytical expressions for estimation of

Mechanisms of Transgene Silencing in Neural Cells -Implications for Ex Vivo Gene Therapy to the Brain

Popular Abstract in Swedish Ett nytt och experimentellt sätt att bota eller lindra sjukdomssymptom är att, istället för att tillföra en medicin, rätta till felet på en genetisk nivå. Detta kan åstadkommas genom att överföra nya, fungerande gener, sk transgener, till celler som då börjar producera protein, som i sin tur kan ge upphov till en terapeutisk effekt. I hjärnan skulle denna typ av behandlThe use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro

Declarative-knowledge-based reconfiguration of automation systems using a blackboard architecture

This article describes results of the work on knowledge representation techniques chosen for use in the European project SIARAS (Skill-Based Inspection and Assembly for Reconfigurable Automation Systems). Its goal was to create intelligent support system for reconfiguration and adaptation of robot-based manufacturing cells. Declarative knowledge is represented first of all in an ontology expressed

Aspects on ADM1 Implementation within the BSM2 Framework

The current work of developing a control simulation benchmark goes back to the work carried out within the COST Action 682 (“Integrated Wastewater Management”) and the IAWQ Task Group on Respirometry-Based control of the Activated Sludge Process in the late 90s. The work was continued in COST Action 624 until 2003 (Copp 2002). In 2005, the IWA Task Group on Benchmarking of Control Strategies for W