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Pharmaceutical co-crystals of the anti-inflammatory drug diflunisal and nicotinamide obtained using supercritical CO2 as an antisolvent

A method based on using supercritical CO2 as an antisolvent (SAS method) is explored as a co-crystallization technique. Co-crystallization is an emerging and powerful technique to improve the physicochemical properties of an active pharmaceutical ingredient. The solid-state and solution co-crystallization methods usually employed present several disadvantages. The one-step SAS method has a low env

The aquaporin splice variant NbXIP1;1α is permeable to boric acid and is Phosphorylated in the N-terminal domain

Aquaporins (AQPs) are membrane channel proteins that transport water and uncharged solutes across different membranes in organisms in all kingdoms of life. In plants, the AQPs can be divided into seven different subfamilies and five of these are present in higher plants. The most recently characterized of these subfamilies is the XIP subfamily, which is found in most dicots but not in monocots. In

To know or not to know – parents’ attitudes to and preferences for prenatal diagnosis

Objective: To highlight expectant parents’ attitudes concerning prenatal diagnosis, what the parents wish to know and what they chose not to know about their unborn baby, also in what form and to what extent they wish for prenatal diagnosis. Background: Parents have to make decisions concerning prenatal diagnosis. Screening programmes change rapidly and there is a need for parental influence on th

Optimal Displacement Parameters in Monte Carlo Simulations

An adaptive algorithm optimizing single-particle translational displacement parameters in Metropolis Monte Carlo simulations is presented. The optimization is based on maximizing the mean square displacement of a trial move. It is shown that a large mean square displacement is strongly correlated with a high precision of average potential energy. The method is here demonstrated on model systems re

Storage stability of freeze-dried, spray-dried and drum-dried skim milk powders evaluated by available lysine

Formation of Maillard products and the influencing factors, which are of crucial importance for both manufacturers and consumers, are still not fully understood. Thus in this study available lysine was used as a marker to monitor the extent of Maillard reactions in freeze-dried, spray-dried and drum-dried skim milk powders during 200 days of storage at highly controlled atmospheres. Storage variab

Analyzing the influence of learning orientation and innovativeness on performance of public organizations : The case of Iran

Purpose – There is growing concern about the performance of public organizations (POs) in developing countries. Despite the fact that the advantages of innovation and learning orientation to organizations have been evidently documented in Western economies and private owned enterprises, there has been little research into these practices and their impact on enhancing competitive advantages in POs

Anomalous temperature behavior in clay swelling due to ion-ion correlations

We show, experimentally and theoretically, that swelling of both natural and refined clays has an anomalous temperature behavior depending on counterion valency. In an aqueous clay dispersion dominated by monovalent counterions the swelling pressure increases with temperature as expected from entropic arguments. In a clay with predominantly divalent counterions, the opposite behavior is found. The

The fan-like forms in the southern margin of the Mazovian Lowland area (Central Poland) : a new high-resolution textural-timing study

An optically stimulated luminescence technique with a high-resolution sampling strategy, as well as a set of multiple proxies such as grain size distribution, shape, surface and microstructures of quartz grains, along with mineral composition of light and heavy fractions was used to investigate the age and origin of fan-like forms at the southern margin of Mazovian Lowland, Poland. The predominanc

Ear-body lift and a novel thrust generating mechanism revealed by the complex wake of brown long-eared bats (Plecotus auritus)

Large ears enhance perception of echolocation and prey generated sounds in bats. However, external ears likely impair aerodynamic performance of bats compared to birds. But large ears may generate lift on their own, mitigating the negative effects. We studied flying brown long-eared bats, using high resolution, time resolved particle image velocimetry, to determine the aerodynamics of flying with

A fast and sensitive method for the separation of carotenoids using ultra-high performance supercritical fluid chromatography-mass spectrometry

In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we

Microemulsions of Record Low Amphiphile Concentrations Are Affected by the Ambient Gravitational Field

It is shown that the ternary system heavy water-heptane-hexadecyl hexaethylene oxide (C16E6) has a stable bicontinuous microemulsion phase down to an exceptionally low concentration at the balanced temperature of 26.8 °C. It is further demonstrated that the ambient gravitational field has an influence on the observed phase equilibria for typical sample sizes (∼1 cm). Direct measurements using a nu

Lateral Protein-Protein Interactions at Hydrophobic and Charged Surfaces as a Function of pH and Salt Concentration

Surface adsorption of Thermomyces lanuginosus lipase (TLL) - a widely used industrial biocatalyst - is studied experimentally and theoretically at different pH and salt concentrations. The maximum achievable surface coverage on a hydrophobic surface occurs around the protein isoelectric point and adsorption is reduced when either increasing or decreasing pH, indicating that electrostatic protein-p

Non-intrusive, in situ detection of ammonia in hot gas flows with mid-infrared degenerate four-wave mixing at 2.3μm

We demonstrate non-intrusive, in situ detection of ammonia (NH3) in reactive hot gas flows at atmospheric pressure using mid-infrared degenerate four-wave mixing (IR-DFWM). IR-DFWM excitation scans were performed in the v2+v3 and v1+v2 vibrational bands of NH3 around 2.3μm for gas flow temperatures of 296, 550 and 820K. Simulations based on spectroscopic parameters from the HITRAN database have be

The Corporate Brand Identity and Reputation Matrix - The case of the Nobel Prize

The purpose of this article is to explore corporate brand identity and reputation, with the aim of integrating them into a single managerial framework. The Nobel Prize serves as an in-depth field-based case study, and is analysed using the Corporate Brand Identity and Reputation Matrix (CBIRM), introduced here for the first time. Eight key reputation elements adapted from the literature and enrich

Two-dimensional OH-thermometry in reacting flows using photofragmentation laser-induced florescence

In the present work, the possibility of using photofragmentation laser-induced fluorescence (PFLIF) for thermometry in different reacting flows is investigated. Hydroxyl (OH) fragments are created by UV-laser (266nm) fragmentation of hydrogen peroxides (H2O2 and HO2), whereupon the fluorescence, induced while scanning the wavelength of a second laser across the A2σ+(v = 1)-X2Π(v = 0) absorption ba

Comparison of heat transfer characteristics of aviation kerosene flowing in smooth and enhanced mini tubes at supercritical pressures

Purpose - The purpose of this paper is to numerically investigate the heat transfer performance of aviation kerosene flowing in smooth and enhanced tubes with asymmetric fins at supercritical pressures and to reveal the effects of several key parameters, such as mass flow rate, heat flux, pressure and inlet temperature on the heat transfer. Design/methodology/approach - A CFD approach is taken and

Model predictive control for software systems with CobRA

Self-adaptive software systems monitor their operation and adapt when their requirements fail due to unexpected phenomena in their environment. This paper examines the case where the environment changes dynamically over time and the chosen adaptation has to take into account such changes. In control theory, this type of adaptation is known as Model Predictive Control and comes with a well-develope

Ninety-one species of lichens and allied fungi new to Latvia with a list of additional records from Kurzeme

The results of lichenological excursions of the 19th Symposium of Baltic Mycologists and Lichenologists (BMLS) in Latvia, Kurzeme region, 22–26 September 2014, are reported. A list of 290 species is presented, of which 238 are lichenized, 43 lichen-inhabiting, and nine saprotrophic fungi: ninety-one species are new to Latvia, twelve of which (Caloplaca duplicata, Cresporhaphis wienkampii, Ellisemb

Connection between modeled blackbody radiation and dipole emission in large-area nanostructures

When modeling the emission of light from nanostructures, we typically study either (1) blackbody radiation or (2) dipole emission. For effective analysis, it is important to know how results from these two types of modeling are related. Here, we use Kirchoff's reciprocity to study how interference affects the emissivity and number of emitted blackbody photons from a thin film for varying thickness