Background: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. Methods: The study included 1

In the present study, the daily dose in terms of particle surface area received by citizens living in five cities in Western countries, characterized by different lifestyle, culture, climate and built-up environment, was evaluated and compared. For this purpose, the exposure to sub-micron particle concentration levels of the population living in Barcelona (Spain), Cassino (Italy), Guilford (United

The aim of this study is to investigate whether certain configurations of management controls dominate in certain societies (socio-cultural contexts) and whether the effectiveness of a given archetype of management control systems (MCSs) varies depending on the socio-cultural setting-the society-in which it operates. The study focuses on three socio-cultural groups and the corresponding institutio

The purpose of this work was to present collective data on firefighter fatalities in Sweden between 1937 and 2016. Data presented is directly related to operations only. Fatalities due to long-term exposure of gases, particles, and physical/psychological stress or similar were not included in the study. Also, accidents involving ambulances as well as fatalities in direct relation to physical trainThe purpose of this work was to present collective data on firefighter fatalities in Sweden between 1937 and 2016. Data presented is directly related to operations only. Fatalities due to long-term exposure of gases, particles, and physical/psychological stress or similar were not included in the study. Also, accidents involving ambulances as well as fatalities in direct relation to physical train

We can trace the beginnings of our knowledge of early Upper Paleolithic (Aurignacian) use of fire to the pioneering 1910–1911 excavations at Abri Blanchard undertaken by Louis Didon and Marcel Castanet. At Blanchard, the excavators recognized and described fire structures that correspond in many ways to features excavated more recently in Western and Central Europe. Here, we address the issue of h

As wintering Whooper Swans Cygnus cygnus have shifted their winter feeding habitats from water to terrestrial ones, the International Waterfowl Counts, covering only coastal and lake sites since its start in 1967, cannot monitor true population change. Therefore, special surveys covering also the terrestrial habitats have been organized in mainland NW Europe every five years since 1995. In January

During the spring 2015, a pair of Common Redstarts Phoenicurus phoenicurus successfully raised a five-chick brood in an artificial nest-box designed for and occupied by a pair of Common Swifts Apus apus in southern Sweden. The breeding was monitored by a nest-box camera, which recorded close interactions between the two species. The Common Redstarts initiated the breeding first and had young in th

The speed and progress of transitions towards renewable energy systems varies greatly between European member states. Among others, these differences have been attributed to the emergence of grassroots initiatives (GIs) that develop radical ideas and sustainable practices. The goal of this paper is to understand the differences in the emergence of GIs for renewable energy in relation to the instit

The focus has recently been directed towards the engine out soot from Diesel engines. Running an engine in PPC (Partially Premixed Combustion) mode has a proven tendency of reducing these emissions significantly. In addition to combustion strategy, several studies have suggested that using alcohol fuels aid in reducing soot emissions to ultra-low levels. This study analyzes and compares the characThe focus has recently been directed towards the engine out soot from Diesel engines. Running an engine in PPC (Partially Premixed Combustion) mode has a proven tendency of reducing these emissions significantly. In addition to combustion strategy, several studies have suggested that using alcohol fuels aid in reducing soot emissions to ultra-low levels. This study analyzes and compares the charac

In this work, we generalize the recent sparse iterative covariance-based estimator (SPICE) by extending the problem formulation to allow for different norm constraints on the signal and noise parameters in the covariance model. The resulting extended SPICE algorithm offers the same benefits as the regular SPICE algorithm, including being hyper-parameter free, but the choice of norms allows further

High pressure reducing valve (HPRV) is widely used for pressure and temperature control of heated steams in power plant and other related process engineering. The structures of throttling components inside HPRVs have important effects on the control performances. In this paper, a parametric study of throttling components in a multi-stage high pressure reducing valve (MSHPRV) is carried out, includ

Biografisk artikel om språkvetaren m m Hjalmar Edgren (1840-1903) med tonvikt på hans period som docent vid Lunds universitet 1880-1885 samt de kontakter med andra lundaakademiker han därvid skaffade sig.

Semiconductor nanowires are often regarded as having potential to be building blocks for novel applications. Their geometry allows defect-free combinations of materials that have a high degree of lattice mismatch. III-V semiconductor nanowires can also be grown in the wurtzite crystal phase, which is not stable in bulk material or thin films. The atomic arrangement differs between wurtzite and zin

Resultaten i denna avhandling ökar vår kunskap om hur evolutionen av feromondetektering hos fjärilar gått till.Luktsinnet är viktigt för de flesta djur, inklusive människor, hundar, insekter och många andra. Hos insekter, särskilt nattfjärilar och flugor, används luktsinnet för att hitta parningspartners, föda, äggläggningsställen och att undkomma fiender.Feromoner är kemikalier som produceras ochIn moths, females produce sex pheromone compounds to attract males over a long distance for mating. The antennae of moths and many other insects have specialized odorant receptors (ORs), called pheromone receptors (PRs), to sense the pheromone compounds and they group in a monophyletic clade (PR clade).In this thesis, I investigated and compared various components of the olfactory system in differ

Cytotoxic T cells infiltrating tumors are thought to utilize HIF transcription factors during adaptation to the hypoxic tumor microenvironment. Deletion analyses of the two key HIF isoforms found that HIF-1α, but not HIF-2α, was essential for the effector state in CD8+ T cells. Furthermore, loss of HIF-1α in CD8+ T cells reduced tumor infiltration and tumor cell killing, and altered tumor vascular

Background: The International Federation of Gynecology and Obstetrics (FIGO) ovarian cancer staging system includes no sub-stage for lymph nodes (LN) as only distant disease manifestation. We explore the prognostic implication of LN as only stage IV classifier in serous ovarian cancer. Method: This is a nation-wide, population-based study on 551 women with serous stage IV cancers diagnosed between

Objective: Studies of the importance of perinatal factors for the development of irritable bowel syndrome (IBS) are sparse. We conducted a large national cohort study to examine perinatal and familial risk factors for IBS. Material and methods: A national cohort of 1,963,685 persons who were born in Sweden in 1973–1992 (identified from the Swedish Birth Registry) were followed up for adult (18 yea