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UNLABELLED: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen signaling. Androgen deprivation therapy and second-generation androgen receptor (AR)-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC), defined by AR and neuroendocrine (NE) markers. Molecular drivers of doubl

What is the effect of foreign events on ideas and discourses at the national level? This paper argues that a foreign event may set in motion an ideational momentum that gives positive attention to certain ideas, strengthening the credibility of political actors that hold these ideas, and hurting the credibility of actors promoting competing ideas. Based on a regression discontinuity design and qua

“Digital participation” refers to being actively involved in the digital society and using information and communication technology, above all the internet. However, not everyone has access to this global network and the ability to use it. The aim of the study was to explore experiences of using the internet and digital participation among people with aphasia (PWA) in Sweden by analysing data from

The intercalation of metals beneath graphene offers a powerful route to stabilizing and protecting novel 2D phases. The epitaxial growth of Pb monolayers on SiC(0001), combined with the relatively large spacing of the suspended graphene, makes this system particularly distinctive. Using low-energy electron diffraction (LEED) and various microscopy techniques—including scanning electron microscopy

This chapter explores the invisibility of religious queers within the public discourse on religion and queerness in Sweden, drawing on personal fieldwork experiences and interviews with queer religious participants who self-identify as either Jews, Christians, or Muslims. While highlighting that the visibilities and invisibilities of religious queers vary across the different religious affiliation

Indonesia is in the process of relocating its capital to a newly built city named Ibu Kota Nusantara (IKN). The first area to be developed is the central area of IKN (KIKN), which includes the main governmental zone (KIPP) and is located in Penajam Paser Utara (PPU), spanning two primary villages, Sepaku and Pemaluan, which are home to the Indigenous Peoples (IP) of the Balik and Paser communities

The EU Battery Regulation (Regulation (EU) 2023/1542) mandates that by February 2027, electronic products must be designed so that users or independent professionals can replace their own batteries. While implementing this legislation in larger devices is relatively straightforward, it is unfortunately more difficult for small wearable electronics, such as in-ear headphones, due to their compact d

Bakgrund: Beslut om livsuppehållande åtgärder (LUÅ) inom akutsjukvård utgör en komplex del av sjuksköterskans yrkesutövning och innebär ofta etiska och emotionella utmaningar. Utförandet av livsuppehållande åtgärder kan medföra att förlängt liv, ibland på bekostnad av en försämrad livskvalitet för patienten. Den akuta och tidskritiska vårdmiljön medför risk för att patientens autonomi, delaktighetBackground: Decisions regarding life-sustaining treatment (LUÅ) in emergency care represent a complex aspect of nursing practice and often involve ethical and emotional challenges. The implementation of life-sustaining treatment can prolong life, sometimes at the expense of the patient’s quality of afterlife. The acute and time-critical care environment entails a risk that the patient’s autonomy,

Bakgrund: Akutsjukvården präglas av hög arbetsbelastning, tidsbrist och begränsade resurser, vilket skapade en spänd arbetsmiljö för sjuksköterskor. Krav-Kontroll-stödmodellen beskriver hur kombinationen av arbetskrav, kontroll och socialt stöd påverkar balans eller obalans, medan coping och resiliens är återhämtningsförmågor som påverkar sjuksköterskan att hantera påfrestningar. Syfte: SjuksköteBackground: Emergency care is characterized by high workload, time constraints, and limited resources, which create a tense work environment for nurses. The Job Demand–Control–Support model describes how the combination of job demands, control, and social support affects balance or imbalance, while coping and resilience are recovery abilities that influence the nurse’s capacity to handle stressors

Över hela världen ingick sjuksköterskor i en första linjen-strid mot viruset SARS CoV-2 som ledde till att COVID-19-pandemin förklarades i mars 2020 (WHO, 2020). Akutmottagningen fungerar som en första instans för de flesta patienter som passerar in till sjukhus vid akut sjukdom vilket ledde till att stora förändringar behövde genomföras på kort tid i form av utökade isoleringsplatser, organise

Bakgrund: Akutmottagningar i Sverige och internationellt står inför utmaningar med ökade patientflöden, överbelastning och långa väntetider. Teamtriage, där olika professioner arbetar och bedömer patienten tillsammans vid ankomst, har utvecklats som en möjlig lösning för att effektivisera vårdflödet. Syfte: Syftet med litteraturstudien var att beskriva teamtriagens effekter på vårdflöde, patientsä

Introduction: Despite factor (F)VIII prophylaxis, a perceived increased risk of bleeding for some people with severe haemophilia A (PwSHA) exists, limiting physical activity (PA) and restricting quality of life (QoL). Aim: HemiNorth 2 (EudraCT# 2020-003256-32) is an interventional study evaluating the impact of switching from FVIII prophylaxis to emicizumab in PwSHA without FVIII inhibitors who ha

Recent technological developments in warehousing have introduced new risks. This paper presents an integrative review that combines insights from highly automated warehouse systems (HAWS) and risk management, providing a comprehensive understanding of technology-related warehouse disruptions and vulnerabilities. We identify five major disruptions that can affect HAWS: cyberattacks, technology sabo

Biases in animal behaviour research are inevitable consequences of our societal and cultural standpoint. To remove our biases, the first stage is to identify them. We call on individual researchers to adopt a more active approach to addressing bias within their research. We propose that biases exist within a matrix defined by the general acceptance of a bias's existence and the understanding of th

Education reduces the intergenerational transfer of poverty and boosts growth according to the Social Investment (SI) approach (Morel, Palier, and Palme 2011). However, educational systems differ in their capacity to promote equality and produce the skills needed in today‘s knowledge economies. Despite extensive scholarship on how education policies vary in terms of their social and economic effec

Massive multiple input, multiple output (MIMO) systems are crucial for enhancing spectral efficiency and link reliability in next-generation wireless communications. However, high Peak-to-Average Power Ratio (PAPR) remains a significant challenge, leading to power inefficiencies and signal distortion. This paper presents a low complexity method for PAPR reduction using hard clipping tailored for f

Background: Infections trigger complex immune responses, with conserved as well as disease-specific characteristics. Methods: Proteomic screening technology and gene expression analysis were used here to define the immune response in infants, with their first episode of febrile urinary tract infection. Urine and peripheral blood samples were obtained at enrollment and at follow-up, after 6 months.

This study examines the current e-learning implementation in Tanzanian universities, highlighting the challenges and opportunities associated with its utilisation. Data was collected from 610 respondents, including e-learning support staff, lecturers, and students from five selected universities through questionnaires and interviews. The findings reveal that universities in Tanzania still face imp

Background: The Earth Hologenome Initiative (EHI) is a global endeavor dedicated to revisit fundamental ecological and evolutionary questions from the systemic host–microbiota perspective, through the standardized generation and analysis of joint animal genomic and associated microbial metagenomic data. Results: The first data release of the EHI contains 968 shotgun DNA sequencing read files conta