An affinity purification procedure for the direct purification of lactoferrin from defatted (skimmed) milk has been developed. The procedure is based on using selected phage clones expressing a peptide with high binding affinity for lactoferrin which were covalently coupled to macroporous poly(dimethylacrylamide) monolithic column. Large pore size (10-100 mu m) of macroporous poly(dimethylacrylami

Changes in fetal motor activity may reflect changes in central nervous function and in the health of the fetus. Recording of fetal movement (FM) has therefore been suggested as a method of assessing fetal well-being. To establish the normal range of FMs in the third trimester of pregnancy, FMs were studied cross-sectionally in 180 and longitudinally in 6 healthy women with normal pregnancies. FMs

Computers are increasingly used for implementing controlalgorithms in safety-critical embedded applications, such asengine control, braking control and flight surfacecontrol. Consequently, computer errors can have severe impact on the safety of such systems. Addressing the coupling of control performance with computer related errors, this paper develops a methodology for analyzing the impact data

This study compared the health-related quality of life (HRQOL) of family members of patients who participated in a program of palliative care (intervention family members) with those in conventional care (control family members). The HRQOL was measured by the short-form (SF-36) health survey questionnaire, including eight subscales. The longitudinal intervention study includes two sites: Trondheim

Context/Objective: To effectively normalize IGF-I in patients with acromegaly, various covariates may affect dosing and plasma concentrations of pegvisomant. We assessed whether sex, age, weight, and previous radiotherapy influence dosing of pegvisomant in patients with active disease. Design: Data from 69 men and 49 women participating in multicenter, open-label trials of pegvisomant were retrosp

Popular Abstract in Swedish De äldsta hajfossil man känner till kommer från devonperioden och är minst 380 miljoner år gamla. Under Mesozoikum (trias, jura och krita) dominerades hajfaunorna av hybodonta hajar under trias och första halvan av jura medan de moderna hajarna (Neoselachii) tog över från slutet av jura och numera är de enda levande hajarna på vår planet. Detta arbete har fokuserats påThe Jurassic and Early Cretaceous selachian faunas of Scania (Skåne), southern Sweden and the island of Bornholm (Denmark) have been investigated. Three Early Jurassic shark tooth assemblages have been recorded and investigated, one from Hettangian strata and the other two from Pliensbachian sediments. The Hettangian assemblage originates from non-marine deposits in the southern part of Helsingbor

Esterification of p-hydroxybenzoic acid, a very weak estrogenic compound, with the daucane alcohol jaeschkeanadiol (1b) leads to a spectacular magnification of the estrogenic activity. To identify the structural elements responsible for this effect, the terpenoid core of jaeschkeanadiol p-hydroxybenzoate (ferutinin, 1a) was modified, capitalizing on the presence of two functionalities, the monoacy

We consider the problem of decomposing polygons (with holes) into various types of simpler polygons. We focus on the problem of partitioning a rectilinear polygon, with holes, into rectangles, and show an Omega (n log n) lower bound on the time-complexity. The result holds for any decomposition, optimal or approximative. The bound matches the complexity of a number of algorithms in the literature,

To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and Z

Proposed is a frequency selective (FS) subspace-based method for determining the model order. A study is made of its performance when applied to estimating the number of sinusoids in white noise. Employing an FS-version of the ESPRIT algorithm, the recent ESTER model order estimation algorithm is extended to allow for the model order estimation on a frequency subset.

Four exposures of Chicxulub impact ejecta along the Mexico-Belize border have been sampled and analyzed for major and trace element abundances. The ejecta deposits consist of a lower spheroid bed, containing clay and dolomite spheroids, and an upper diamictite bed with boulders and clasts of limestone and dolomite. The matrix of both beds is composed of clay and micritic dolomite. The rare earth e

A number of techniques for non-linear analysis of time series data have been developed in recent years and applied in many environmental sciences. In this paper, some of these techniques are reviewed and their usefulness for coastal morphological data assessed, with examples in coastal morphology and related fields where these are available. The methods reviewed are time-delay embedding techniques

Extensive studies of mice deficient in one or several cytokine receptors have failed to support an indispensable role of cytokines in development of multiple blood cell lineages. Whereas B1 B cells and Igs are sustained at normal levels throughout life of mice deficient in IL-7, IL-7R{alpha}, common cytokine receptor gamma chain, or flt3 ligand (FL), we report here that adult mice double deficient

The single most important factor related to the development of diabetic retinopathy is the duration of diabetes. Little is known about the underlying mechanisms, but many factors have been suggested to be involved, among them derangements in plasma lipids and plasma lipoproteins. In the present study we examined the relation between plasma lipids, plasma lipoproteins, and the duration of diabetes