Open Source Software (OSS) ecosystems have reshaped the ways how software-intensive firms develop products and deliver value to customers. However, firms still need support for strategic product planning in terms of what to develop internally and what to share as OSS. Existing models accurately capture commoditization in software business, but lack operational support to decide what contribution s

Colony forming or clonogenic assay is an in vitro quantitative technique to examine the capability of a single cell to grow into a large colony through clonal expansion. Clonogenic activity is a sensitive indicator of undifferentiated cancer stem cells. Here, we described the colony forming ability of the isolated breast cancer stem cells from the total population of cancer cells using double-laye

As semiconductor electronics keep shrinking, functionality depends on individual atomic scale surface and interface features that may change as voltages are applied. In this work we demonstrate a novel device platform that allows scanning tunneling microscopy (STM) imaging with atomic scale resolution across a device simultaneously with full electrical operation. The platform presents a significan

Associations between long-Term exposure to ambient air pollution and cognitive function have been observed in a few longitudinal studies. Our aim was to investigate the association between long-Term exposure to air pollution and episodic memory, a marker of early cognitive decline. We used data from the Betula study in Northern Sweden, and included participants 60 to 85 of age at inclusion, 1,469

The objective of this paper is to show the results of an industrial project dealing with modelling of anaerobic digesters. A multi-scale mathematical approach is developed to describe reactor hydrodynamics, granule growth/distribution and microbial competition/inhibition for substrate/space within the biofilm. The main biochemical and physico-chemical processes in the model are based on the Anaero

Purpose The recruitment of participants to randomized controlled trials (RCTs) in palliative cancer care by health care professionals is often unsuccessful, which could result in failure to achieve study power. The purpose of this paper is to describe how health care professionals experienced recruiting patients and family caregivers to an RCT in palliative cancer care. Methods The study had a qua

Phosphatidylethanol (PEth) is an interesting biomarker finding increased use for detecting long term alcohol abuse with high specificity and sensitivity. Prior to detection, sample preparation is an unavoidable step in the work-flow of PEth analysis and new protocols may facilitate it. Solid-phase extraction (SPE) is a versatile sample preparation method widely spread in biomedical laboratories du

For chemically enhanced primary treatment (CEPT) with microsieving, a feedback proportional integral controller combined with a feedforward compensator was used in large pilot scale to control effluent water turbidity to desired set points. The effluent water turbidity from the microsieve was maintained at various set points in the range 12-80 NTU basically independent for a number of studied vari

The transverse momentum (pT) spectra and elliptic flow coefficient (v2) of deuterons and anti-deuterons at mid-rapidity (| y| < 0.5) are measured with the ALICE detector at the LHC in Pb–Pb collisions at sNN = 2.76 TeV. The measurement of the pTspectra of (anti-)deuterons is done up to 8 GeV/ c in 0–10% centrality class and up to 6 GeV/ c in 10–20% and 20–40% centrality classes. The v2is measured

We present a digital phase-locked loop (DPLL) operating from 2.8 to 3.8 GHz with an on-chip 40-MHz reference crystal oscillator. The DPLL makes use of a class-D digitally controlled oscillator and a digital-to-time converter with a single-bit (bang-bang) phase detector. The DPLL displays an excellent behavior in terms of in-band fractional spurs, which are consistently below -65 dBc across the tun

The ecosystem services (ES) concept refers to benefits that humanity receives from nature. Investigating how this concept has been embraced within urban planning is important when assessing the awareness of human dependence on natural functions and the potential for the ES concept to increase this awareness. We analyzed planning documents from three small and three large municipalities in southern

Humid air motor (HAM) is an engine operated with humidified inlet charge. System simulations study on HAM showed the waste heat recovery potential over a conventional system. An HAM setup was constructed, to comprehend the potential benefits in real-time, the HAM setup was built around a 13-litre six cylinder Volvo diesel engine. The HAM engine process is explained in detail in this paper. Emissio

This paper investigates the causal effects of monetary policy on the British economy during the classical gold standard. Based on the narrative identification approach, I find that following a one percentage point monetary tightening, unemployment rose by 0.9 percentage points, while inflation fell by 3.1 percentage points. In addition, monetary policy shocks accounted for a third of macroeconomic

Partially premixed combustion (PPC) can be applied to decrease emissions and increase fuel efficiency in direct injection, compression ignition (DICI) combustion engines. PPC is strongly influenced by the mixing of fuel and oxidizer, which for a given fuel is controlled mainly by (a) the fuel injection, (b) the in-cylinder flow, and (c) the geometry and dynamics of the engine. As the injection tim

The addition of hydrogen to swirl stabilized methane-air flame in gas turbine has gained more and more attentions in recent years. In the current study, flame structures, flame dynamics and lean blowout limits of partially premixed hydrogen-methane-air flames were investigated. The swirling flow, which was generated from the tangential flow injection, was utilized to stabilize the flame. The flow

Film cooling technology is commonly used in a cooling system of gas turbines. For different upstream bulge configurations, the unconnected and connected configurations were used to investigate the film cooling effectiveness and downstream dimensionless temperature distributions in this paper. Moreover, the effect of the blowing ratio was analyzed by using the computational fluid mechanics. The res

The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. The thesis gives an overview of the field for network inference and deconvolution methods, as well as a brief background on th

Group-based microfinance programmes, based on trust and solidarity among members, currently dominate development policy and practice as the approach compensates for individual poor’s lack of material resources and market imperfections. Despite strong evidence of its social and economic impact, few researches take an in-depth, empirical look at how the group models manifest and create social capita

The road safety development in East-European countries follows in general the trends of the western countries, even though there is a time lag. The fatality numbers are decreasing, though the improvements for the vulnerable road users are less impressive compared to other road user categories. The traditional road safety analysis based on accident history has many limitations related to accident u