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Stroke is one of the leading causes of mortality and morbidity worldwide, and few therapeutic treatments have shown beneficial effect clinically. One reason for this could be the lack of risk factors incorporated into the preclinical stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats.

During the summer of 2015, India was hit by a scorching heat wave that melted pavements in Delhi and caused thousands of deaths, mainly among the most marginalized populations. One such group facing growing heat risks from both occupational and meteorological causes are migrant brick kiln workers. This study evaluates both current heat risks and the potential future impacts of heat caused by clima

Employment discrimination causes problems at the labor market, and is hard to combat. Can increasing the degree of structure when selecting applicants increase fairness? Students were asked to perform a computerized selection task and were either provided with tools for systematizing information about the applicants (structured selection) or no such tools (unstructured selection). We hypothesized

Previous research carried out by the authors described the role of dual-fuel combustion efficiency on overall engine efficiency at high diesel substitution ratio. At low loads, high diesel substitution ratios result in excessive total unburned hydrocarbon emissions due to bulk flame quenching, and consequently lower substitution ratios in combination with intake air heating, throttling and increas

Gasoline partially premixed combustion (PPC) has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions. The problem is the ignitability at low load and idle operating conditions.In a previous study it was shown that it is possGasoline partially premixed combustion (PPC) has the potential of high efficiency and simultaneous low soot and NOx emissions. Running the engine in PPC mode with high octane number fuels has the advantage of a longer premix period of fuel and air which reduces soot emissions. The problem is the ignitability at low load and idle operating conditions.In a previous study it was shown that it is poss

Background: Amino acid substitutions due to DNA nucleotide replacements are frequently disease-causing because of affecting functionally important sites. If the substituting amino acid does not fit into the protein, it causes structural alterations that are often harmful. Clashes of amino acids cause local or global structural changes. Testing structural compatibility of variations has been diffic

Whether abduction is treated as an argument or as an inference, the mainstream view presupposes a tight connection between abduction and inference to the best explanation (IBE). This paper critically evaluates this link and supports a narrower view on abduction. Our main thesis is that merely the hypothesis-generative aspect, but not the evaluative aspect, is properly abductive in the sense introd

Background: Early diagnosis of traumatic acute full-thickness rotator cuff tears (FTRCT) is important to offer early surgical repair. Late repairs following fatty infiltration of the rotator cuff muscles have less favorable results. We think that physical therapists are valuable diagnosticians in a screening process. The objective of this study was to evaluate the usefulness of physical therapists

Objective: The primary objective was to evaluate 6-month outcomes for brief and extensive automated telephony interventions targeting problematic alcohol use, in comparison to an assessment-only control group. The secondary objective was to compare levels of problematic alcohol use (hazardous, harmful or probable dependence), gender and age among study participants from clinical psychiatric and ad

Hybrid powertrains have become a very attractive technology over the last ten years due to their potential for lowering fuel consumption and emissions. A large portion of all manufacturers worldwide are now focusing on hybrid electric powertrains, which are the most common hybrid powertrains of today. However, in recent years a new technology has emerged, namely the pneumatic hybrid powertrain. Al

The prognostic importance of tumor-specific nuclear insulin receptor (InsR) expression in breast cancer is unclear, while membrane and cytoplasmic localization of InsR is better characterized. The insulin signaling network is influenced by obesity and may interact with the estrogen receptor a (ERα) signaling. The purpose was to investigate the interplay between nuclear InsR, ER, body mass index (B