Objective A common threonine481serine polymorphism (T481S) has been shown in vitro to strongly activate the chloride channel Kb (CLC-Kb) expressed in the kidney, and the 481S allele has been associated with human hypertension. The study aim was to evaluate the association of the T481 S polymorphism with blood pressure (BP) levels and the BP progression rate in Swedes. Design and methods The cardio

How can tools help structure tasks to make them cognitively easier to perform? How do artefacts, and our strategies for using them, develop over time in cognitively beneficial ways? These are two of the main questions that are explored in the five papers collected in this thesis. The first paper details an ethnographic study conducted on people cooking in their homes. The study is a first pass ov

Purpose: To compare the longitudinal suture model for bridging nerve defects with direct approximation under tension or with autologuos nerve grafting. Methods: Seven mm nerve defects in the rat sciatic nerve were repaired by either of these three methods. Evaluation was performed at twelve weeks by morphometry of the tibial nerve distal to the repair site and by weight of the gastrocnemius muscl

"This report presents the results of ten projects in which we have used microcalorimetric techniques to study processes in building materials. Except for in cement research, microcalorimetry has not been much used on building materials. The microcalorimetric technique is extremely versatile, mainly because it is a very basic property (heat) that is measured. We hope that this report may encourage

Plants of the partially self-incompatible perennial herb Brassica cretica, derived from contralled cross- and self-pollinations within each of seven populations, were raised under uniform conditions and scored for two measures of developmental stability, flower asymmetry (quantified as the difference in length and width between opposite petals) and cotyledon asymmetry (quantified as the difference

Premixed turbulent flame-based technologies are rapidly growing in importance, with applications to modern clean combustion devices for both power generation and aeropropulsion. However, the gain in decreasing harmful emissions might be canceled by rising combustion instabilities. Unwanted unsteady flame phenomena that might even destroy the whole device have been widely reported and are subject t

A scintillating fibre tracker is proposed to measure elastic proton scattering at very small angles in the ATLAS experiment at CERN. The tracker will be located in so-called Roman Pot units at a distance of 240 m on each side of the ATLAS interaction point. An initial validation of the design choices was achieved in a beam test at DESY in a relatively low energy electron beam and using slow off-th

Ferrochelatase, the enzyme catalyzing metallation of protoporphyrin IX at the terminal step of heme biosynthesis, was co-crystallized with an isomer mixture of the potent inhibitor N-methylmesoporphyrin (N-MeMP). The X-ray structure revealed the active site of the enzyme, to which only one of the isomers was bound, and for the first time allowed characterization of the mode of porphyrin macrocycle

Radiative lifetime measurements were performed with time-resolved laser-induced fluorescence techniques for 47 levels of the astrophysically important ion Sm1+ over the energy range 21000-36 000 cm(-1). The new results have been compared with previous measurements but also with theoretical calculations taking configuration interactions and core-polarization effects into account, and a satisfying a

In this thesis we study the critical Ginzburg-Landau action, defined on fields in the plane which are allowed to have a finite number of singularities. We show that a topological invariant, the degree, can be defined under the assumption of finite action only. The action is bounded below by a constant times the degree, and the fields which realize this lower bound satisfy a first order differentia

Artikeln undersöker det för rätten fundamentala begreppet "tiden". Utgångspunkt är president George W. Bushs krig mot krig mot terrorismen - the War on Terrorism - med exempel från invasionen och den påföljande ockupationen av Irak. Artikeln argumenterar för en eskatologisk förståelse av rätten under the War on Terrorism, något som förskjuter tidens perspektiv, och som påvisar ett undantagstillstå

A method for determining hexahydrophthalic (HHP acid) and methylhexahydrophthalic acids (MHHP acid) from human urine was developed. These acids are metabolites of the highly sensitising hexahydrophthalic anhydride and methylhexahydrophthalic anhydride. The acids were purified from urine by liquid-solid extraction and derivatised with pentafluorobenzyl bromide to the corresponding esters. These wer