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Background: Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention of type 1 diabetes will require early intervention in genetically at-risk infants. The objective of this study was to determine to what extent genetic scores (two previous genetic scores and a merged genetic score) can imp

Objectives Our aim was to use the opportunity provided by the European Scleroderma Observational Study to (1) identify and describe those patients with early diffuse cutaneous systemic sclerosis (dcSSc) with progressive skin thickness, and (2) derive prediction models for progression over 12 months, to inform future randomised controlled trials (RCTs). Methods The modified Rodnan skin score (mRSS)

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship b

The literature on regional innovation systems emphasizes the role of the region as locus for interactive learning and knowledge exchange, stressing the importance of (geographical) proximity for innovation. Even though the importance of extra-regional knowledge is widely acknowledged, there has been only little emphasis on the particular role and the nature of global knowledge flows. The aim of th

Seven native residues on the regulatory protein calmodulin, including three key methionine residues, were replaced (one by one) by the vibrational probe amino acid cyanylated cysteine, which has a unique CN stretching vibration that reports on its local environment. Almost no perturbation was caused by this probe at any of the seven sites, as reported by CD spectra of calcium-bound and apo calmodu

We analyse the effect of business model innovation (BMI) on the product innovation performance of firms, based on a dynamic capabilities theoretical framework. Our empirical study is based on a large-scale representative sample of cross-industry Swedish firms participating in three waves of the Community Innovation Survey (CIS) from 2008 to 2012. We hypothesise that BMI in the form of product inno

En handskrift som en gång tillhörde Alvastra kloster, nu Uppsala Universitetsbibliotek C 37, innehåller en delvis kalendariskt ordnad predikosamling nedskriven i början av 1200-talet, utan kända paralleller. Artikeln beskriver samlingen och konstaterar att innehållet har både monastisk och folklig prägel. En möjlig slutsats är att en munk i Alvastra har sammanställt/författat predikningarna för at

The design of antennas for compact multiple-input multiple-output (MIMO) terminals is a challenging feat, due to the space constraint and the physical structure of the terminal. The space constraint forces the antennas to be closely spaced, which degrades MIMO performance due to high signal correlation and low antenna efficiency. Moreover, the terminals are equipped with ground planes which furthe

For multiple antennas on a compact terminal chassis, chassis current excitation can severely increase mutual coupling between the antennas. This is because the same characteristic mode of the chassis may be strongly excited by more than one antenna. Here, we propose to use one antenna that exploits chassis excitation and introduce a second antenna that minimizes chassis excitation. In this way, an

In this paper, we compare capacity performances of three terminal dual-antenna configurations at 2.65 GHz based on extensive 2 by 2 multiple-input multiple-output (MIMO) channel measurements in an urban macrocellular environment. Both noise- and interference-limited scenarios are investigated. Our results show that, on average over the measurement route, the capacity performance is mainly determin

In this paper, we study the influence of current localization on the isolation between two antennas in a compact terminal setting. The two antennas are chosen to be a monopole and a PIFA. The degree of current localization is controlled by the permittivity value of the PIFA’s dielectric loading. Both lossless and lossy cases are simulated in order to ascertain the underlying performance impact fro

The development of MIMO over-the-air (OTA) test methodology is an ongoing activity in 3GPP RAN4, CTIA and EU COST Action 2100. In this paper, the focus is on the anechoic chamber approach, which uses a uniform circular array of probe antennas to replicate directional channels for the device-under- test at the array center. In particular, we study in simulation the complexity requirements of implem

We study the potential benefits of cooperative multiple-input multiple-output signaling from multiple coherent base stations with one or more mobile stations in an urban macrocellular environment. The analysis uses novel and fully coherent measurements of the channel from three base stations to a single mobile station equipped with four antennas. The observed channels are used to explore the gains

The compactness of mobile terminals complicates the design of multiple antennas, since coupling among the antennas increases when they are placed in proximity of one another. While it is possible to mitigate coupling between closely spaced antennas, a tradeoff in bandwidth is required. In this paper, we highlight ground plane excitation as an additional dimension to consider in the design of multi

Pt-Rh alloy nanoparticles on oxide supports are widely employed in heterogeneous catalysis with applications ranging from automotive exhaust control to energy conversion. To improve catalyst performance, an atomic-scale correlation of the nanoparticle surface structure with its catalytic activity under industrially relevant operando conditions is essential. Here, we present x-ray diffraction data

Part 1: From Brain to GutThe brain is an organ with a high energy requirement. To meet this demand, the brain needs a continuous and well-regulated blood supply. In situations where the brain, or parts of the brain, does not receive sufficient blood flow injury arise. This condition, commonly known as cerebral ischemia, is prevalent in today's society. In 2015, more than 6 million people died from

We measured methane fluxes of a patterned bog situated in Siikaneva in southern Finland from six different plant community types in three growing seasons (2012-2014) using the static chamber method with chamber exposure of 35 min. A mixed-effects model was applied to quantify the effect of the controlling factors on the methane flux.The plant community types differed from each other in their water

Background: Atopic disorders are a global concern. Studies in migrant populations can illuminate the interplay of genetic and environmental factors. Exposures related to bad housing (indoor dampness, mould growth, crowding etc.) are likely to play a role in how socioeconomic inequalities can turn into health disparities for disadvantaged populations. The sizable immigrant population living in very