Cancer cells reside amongst a complex milieu of stromal cells and structural features known as the tumor microenvironment. Often cancer cells divert and co-opt functions of stromal cells of the microenvironment to support tumor progression and treatment resistance. During therapy targeting cancer cells, the stromal cells of the microenvironment receive therapy to the same extent as cancer cells. S

Context-specific control mechanisms of hypoxia-inducible transcription factors HIF-1alpha and HIF-2alpha in tumors exposed to oxygen shortage remain incompletely understood. In this issue, Zhang et al (2022) identify a deubiquitinase that differentially stabilizes HIF-2alpha in stem-like glioblastoma cells, suggesting potential implications for regulation of the hypoxic response in a wide array of

I princip alla kemiska processer och reaktioner som sker i miljön sker i närvaro av joner. I vatten sätter joner förutsättningarna för hur andra lösta partiklar samverkar. Joner är också direkt involverade i kemiska reaktioner som påverkar klimatet såsom ozonnedbrytning.I denna avhandling introduceras läsaren för de drivkrafter som styr molekylära system. Utifrån begreppen energi och entropi guidaEssentially all chemical processes and reactions occurring in the environment take place in the presence of ions. In water, ions set the conditions for how other dissolved particles interact. Ions are also directly involved in chemical reactions affecting the climate such as ozone depletion. In this thesis, the reader is introduced to the driving forces governing molecular systems. Starting from t

The consecutive binding of two potassium ions to a bis(18-crown-6) analogue of Tröger’s base (BCETB) in water was studied by isothermal titration calorimetry using four different salts, KCl, KI, KSCN, and K2SO4. A counterintuitive result was observed: the enthalpy change associated with the binding of the second ion is more negative than that of the first (ΔH°bind,2 < ΔH°bind,1). This remarkable f

This paper is a part of a larger project where we longitudinally (over seven years) analyze the implementation process of a policy instigating written assessment criteria for all courses in a traditional university faculty. The overarching question is: How does educational policy influence educational practice? The project adhere to a complex perspective on implementation (Gornitzka et al., 2005) This paper is a part of a larger project where we longitudinally (over seven years) analyze the implementation process of a policy instigating written assessment criteria for all courses in a traditional university faculty. The overarching question is: How does educational policy influence educational practice?The project adhere to a complex perspective on implementation (Gornitzka et al., 2005) a

Continuous practices including continuous integration, continuous testing, and continuous deployment are foundations of many software development initiatives. Another very popular industrial concept, DevOps, promotes automation, collaboration, and monitoring, to even more empower development processes. The scope of this thesis is on continuous monitoring and the data collected through continuous m

Objectives: Interstitial lung disease is frequent in SSc (SSc-ILD) and associates with significantly reduced quality of life. Here we aimed to analyse patient pathways, and experiences of patients and healthcare providers (HCPs) in order to identify unmet needs in the management of SSc-ILD patients. Methods: Semi-structured qualitative interviews conducted in eight European countries looked at HCP

OBJECTIVE: Untreated perinatal HIV-1 infection is often associated with rapid disease progression in children with HIV (CWH), characterized by high viral loads and early mortality. TRIM22 is a host restriction factor, which directly inhibits HIV-1 transcription, and its genotype variation is associated with disease progression in adults. We tested the hypothesis that TRIM22 genotype is associated