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A unique PE_PGRS protein inhibiting host cell cytosolic defenses and sustaining full virulence of Mycobacterium marinum in multiple hosts

Despite intense research, PE_PGRS proteins still represent an intriguing aspect of mycobacterial pathogenesis. These cell surface proteins influence virulence in several pathogenic species, but their diverse and exact functions remain unclear. Herein, we focussed on a PE_PGRS member from Mycobacterium marinum, MMAR_0242, characterized by an extended and unique C-terminal domain. We demonstrate tha

Speaking about the normativity of meaning

Contemporary debate on the nature of meaning centres on whether meaning is normative. Agreement is widespread that meaning implies correctness, but disagreement on whether correctness is normative remains. Normativists argue that correctness implies obligations or permissions. Antinormativists disagree and hold that correctness is a descriptive term. This paper argues that, fundamentally, meaning

Seeking explanations for recent changes in abundance of wintering Eurasian Wigeon (Anas penelope) in northwest Europe

We analysed annual changes in abundance of Eurasian Wigeon (Anas penelope) derived from mid-winter International Waterbird Census data throughout its northwest European flyway since 1988 using log-linear Poisson regression modelling. Increases in abundance in the north and east of the wintering range (Norway, Sweden, Denmark, Germany, Switzerland), stable numbers in the central range (Belgium, Net

Nya stenåldersfynd från norra Skåne : den första kvartsboplatsen

I samband med fortsatta omlandsstudier inom det s.k. E4-projektet i norra Skåne inventerades i maj-juni 1997 sjösystemen mellan Eket och länsgränsen. Flera tidigmesolitiska lokaler återbesöktes och ytterligare boplatser påträffades. En av de mest intressanta nyfunna lokalerna ligger i anslutning till Naturskolan vid Hjälmsjöns östligaste del. Där hittades den första kvartsdomineradeboplatsen i Skå

Yersinia enterocolitica-specific infection by bacteriophages TG1 and φR1-RT is dependent on temperature-regulated expression of the phage host receptor OmpF

Bacteriophages present huge potential both as a resource for developing novel tools for bacterial diagnostics and for use in phage therapy. This potential is also valid for bacteriophages specific for Yersinia enterocolitica. To increase our knowledge of Y. enterocolitica- specific phages, we characterized two novel yersiniophages. The genomes of the bacteriophages vB_YenM_TG1 (TG1) and vB_YenM_φR

An Antropologist of Sound

PROFESSOR PORTRAIT: Sanne Krogh Groth met Holger Schulze, newly appointed professor in Musicology at the Department for Arts and Cultural Studies, University of Copenhagen, to a talk about anthropology of sound, sound studies, musical canons and ideology.

Spatial variation in climate mediates gene flow across an island archipelago

High levels of gene flow among partially isolated populations can overwhelm selection and limit local adaptation. This process, known as “gene swamping,” can homogenize genetic diversity among populations and reduce the capacity of a species to withstand rapid environmental change. We studied brown anole lizards (Anolis sagrei) distributed across seven islands in The Bahamas. We used microsatellit

Tågerup - fifteen hundred years of Mesolithic occupation in Western Scania, Sweden: a preliminary view.

The slopes of the Tågerup promontory in western Scania contain one of the largest known Mesolithic settlements that has ever been excavated in Scandinavia. The Tågerup site displays a unique combination of huts and houses, graves and wooden implements, flints and bones which constitute a 1500-year-long Mesolithic occupation sequence, dated 6500–5000 cal BC. During that time, there were gradual but

Density fluctuations of hard-sphere fluids in narrow confinement

Spatial confinement induces microscopic ordering of fluids, which in turn alters many of their dynamic and thermodynamic properties. However, the isothermal compressibility has hitherto been largely overlooked in the literature, despite its obvious connection to the underlying microscopic structure and density fluctuations in confined geometries. Here, we address this issue by probing density prof

Smart polymers as surface modifiers for bioanalytical devices and biomaterials : Theory and practice

Smart, or responsive polymers can reversibly change their state of aggregation, thus switching from water-soluble to insoluble state, in response to minor changes in temperature, pH or solvent composition. Grafting of these polymers to solid surfaces imparts the surfaces with controllable wettability and adsorption behaviour. The review summarizes the theoretical models and the results of physical

Molcas: a program package for computational chemistry.

The program system MOLCAS is a package for calculations of electronic and structural properties of molecular systems in gas, liquid, or solid phase. It contains a number of modern quantum chemical methods for studies of the electronic structure in ground and excited electronic states. A macromolecular environment can be modeled by a combination of quantum chemistry and molecular mechanics. It is f