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Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char

Abstract in UndeterminedThe digital age has brought with it advantages and disadvantages. Few would deny the benefit of being able to store entire song collections on pocket-sized MP3 players. Fewer still would disregard the merits of grandparents in Sydney being able to have face-to-face conversations with grandchildren in Berlin.Certain problems however, have also developed. The music and film i

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Problems concerning quality and productivity in the construction sector have been a recurrent issue for many years and seem to remain in spite of various initiatives for resolving them. This situation is a result of human action. From social sciences we know that psychological factors crucially influence action design. Knowledge of this influence seems however to be underestimated in the construct

Two storms in Sweden 2005 and 2007 clarified both professional crisis managers and citizens' ability to respond to the consequences. These events created an awareness of the vulnerability of society, especially in rural areas. Emergent Citizen Groups (ECG) conducted initially a large part of crisis management, such as clearing roads, supporting exposed neighbors and repairing power lines in collab

In large-scale multi-project software engineering it is a challenge to provide a comprehensive overview of the complexity and dynamics of the requirements engineering process. This paper presents a visualization technique called Feature Transition Charts (FTC) that gives an overview of scoping decisions involving changes across multiple projects based on previous work on within-project visualizati

The main focus of this contribution consists in the elaboration of a continuum modelling approach accounting for dislocation-based quantities. Related deformation dependent history-variables are attached to individual material points and, moreover, are extended by means of gradients thereof so that so-called weak non-localities are captured. These gradients of internal variables may be further spe

In order to compete on the international market, companies today need to optimize their production continually. One way to achieve this is to minimize the frequency and length of downtime in the production. The downtimes in a particular manufacturing line were classified on the basis of what generated them; a production performance analysis was carried out, and then a cost model was applied to the