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El Niño–Southern Oscillation (ENSO) events, whether in warm or cold phases, that persist for two or more consecutive years (multi-year), are relatively rare. Compared with single-year events, they create cumulative impacts and are linked to extended periods of extreme weather worldwide. Here we combine central Pacific fossil coral oxygen isotope reconstructions with a multimodel ensemble of transi

Autoimmune thyroid disease (AITD) is associated with other autoimmune endocrine diseases such as type 1 diabetes (T1D) and celiac disease (CeD). Thyroid peroxidase autoantibodies (TPOA) are biomarkers of AITD but may also occur in patients with other autoimmune diseases. We examined cross-sectional correlations between TPOA and an array of immune markers in a cohort of 90 children with exclusively

Objectives: To determine clinical characteristics, outcome and occurrence of comorbidities in patients with biopsy-confirmed giant cell arteritis (GCA) treated with intravenous methylprednisolone (IVMP) vs those receiving oral glucocorticoids (OGC) only. Methods: A retrospective study included patients with GCA diagnosed from 2004 through 2019. Clinical and laboratory characteristics, and cumulati

Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before

Background: Depression and suicidal behavior have been linked to increased blood-brain barrier (BBB) permeability. Platelet-derived growth factor receptor beta (PDGFR-β) is widely expressed in pericytes and promotes BBB integrity. Here, we investigated cerebrospinal fluid (CSF) levels of PDGFR-β in suicide attempters and healthy controls and correlated PDGFR-β to depression symptom severity. Metho

Aims The REDUCE-AMI trial showed that beta-blockers in patients with preserved left ventricular ejection fraction (LVEF) after acute myocardial infarction (AMI) had no effect on mortality or cardiovascular outcomes. The aim of this substudy was to evaluate whether global longitudinal strain (GLS) is a better prognostic marker than LVEF, and if beta-blockers have a beneficial effect in patients wit

Attosecond photoelectron interferometry based on the combination of an attosecond pulse train and a synchronized infrared field is a fundamental technique for the temporal characterization of attosecond waveforms and for the investigation of electron dynamics in the photoionization process. In this approach, the comb of extreme ultraviolet harmonics typically lies above the ionization threshold of

Introduction: Ambient air pollution and road traffic noise are stroke risk factors, but evidence on their potential joint effects remains limited. This study investigated the independent and joint associations of air pollution and road traffic noise on stroke incidence using both multiplicative and additive scales. Methods: We followed stroke incidence in ten cohorts in Sweden, Denmark, and Finlan

Objective Previous research on interprofessional learning in primary healthcare has been focused on students' learning in the encounter with the patient. However, the research is limited, and a review of the experiences of patients, students, and supervisors of interprofessional learning in primary healthcare is lacking. The focus of this scoping review is to describe the current knowledge and als

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinica

Global biodiversity is rapidly declining due to habitat degradation and genomic erosion, highlighting the urgent need to monitor endangered species and their genetic health. Temporal genomics and ecological modelling offer finer resolution than single-Time-point measurements, providing a comprehensive view of species' recent and future trajectories. We investigated genomic erosion and environmenta

How does new technology impact labor market outcomes? We address this question by examining the adoption of electricity in Sweden during the early 20th century. Leveraging detailed individual-level data that covers the entire labor market and exogenous variation in electricity access driven by proximity to hydro-power plants, we estimate the impact of electrification on individual labor market out

Permanent ponds are key landscape units that supply various ecosystem services. Notably, the export of aquatic subsidies to land via emerging insects may significantly influence terrestrial food webs. Polyunsaturated fatty acids (PUFA), which enhance consumer fitness, are among the essential exported components. The patterns and drivers of dietary exports from ponds via insects remain poorly known

Denna avhandling undersöker överlevnad och långsiktiga utfall hos kritiskt sjuka COVID-19-patienter som vårdades på intensivvårdsavdelningar (IVA) i Skåne mellan maj 2020 och maj 2021. Vi syftade till att fylla kunskapsluckor genom att genomföra en prospektiv, multicenterstudie där vi följde 498 IVA-patienter under tre år och utvärderade dödlighet, funktionella, fysiska och psykiska utfall, samt hThis thesis investigates the survival and long-term outcomes of critically ill COVID-19 patients admitted to intensive care units (ICUs) in the Skåne region of Sweden between May 2020 and May 2021. We aimed to address knowledge gaps by conducting a prospective, multicentre cohort study following 498 ICU patients over three years, evaluating mortality, functional, physical, and mental outcomes, as

Tool-based code review has been an established software engineering practice for at least a decade. However, while software development environments have improved significantly during this time with advanced features for code comprehension, refactoring, and AI support, code review tools have remained more static and are still centered around a two-way textual diff view with features similar to whe