Is the oncogene MYC upregulated or hyperactive? In the majority of human cancers, finding agents that target c-MYC has proved difficult. Here we report specific bacterial effector molecules that inhibit cellular MYC (c-MYC) in human cells. We show that uropathogenic Escherichia coli (UPEC) degrade the c-MYC protein and attenuate MYC expression in both human cells and animal tissues. c-MYC protein

This paper examines the association between daytime electric lighting use and perceived indoor daylight availability in residential spaces. In addition, occupant preferences were evaluated, in particular which rooms are prioritized in terms of daylight availability. The study deployed a questionnaire survey that was carried out in typical multi-dwelling apartment blocks in Malmö, Sweden (Latitude:

In prospective observational cohort studies, increasing sun exposure habits have been associated with reduced risk of cardiovascular mortality. Our aim was to assess possible observational mechanisms for this phenomenon. A written questionnaire was answered by 23,593 women in the year 2000 regarding risk factors for melanoma, including factors of possible interest for hypertension, such as detaile

OBJECTIVE: Islet autoimmunity develops before clinical type 1 diabetes and includes multiple and single autoantibody phenotypes. The objective was to determine age-related risks of islet autoantibodies that reflect etiology and improve screening for presymptomatic type 1 diabetes.RESEARCH DESIGN AND METHODS: The Environmental Determinants of Diabetes in the Young study prospectively monitored 8,55

Women are at increased risk of complications after Cesarean section (CS) postpartum and in subsequent pregnancy and delivery. The overall aim of the thesis was to evaluate complications after CS, outline options for their management and to assess strategies to increase the rate of vaginal deliveries after CS (VBAC).Paper I was a prospective study where women were offered to have an additional appo

The aim of this chapter in the report book in Sociology of Law, and Child Rights Institute, Lund University, is to sum up and report, in a summarizing overview in an Introduction our main experiences of Child Rights in Education during 18 years as researchers and teachers in the Sida international training program on "Child Rights, Classroom and School Management".The aim of this report book in Sociology of Law, and Child Rights Institute, LundUniversity, is to sum up and report, in a summarizing overview in the Introduction our main experiences of Children´s Rights in Education during 18 years in the Global South as researchers and teachers.

This article seeks to elucidate that influence by examining the Malazim [Lectures] of Hussein al-Houthi, the founder of the Houthi movement in Yemen, and comparing them to the ideas and visions of Hassan al-Banna, the founder and theoretician of the Muslim Brotherhood group, as was evident in the book called: Rasa'il Hassan al-Banna, [Messages of Hassan al-Banna] and it will work to clarify the es

Organised on the 16 November 2020, the roundtable on “Sharing Cities – Shaping Tomorrow” focused on sharing insights and ideas on the future of sharing in our cities and communities. The roundtable gathered over 40 people from around world and formed part of the Smart City Live Conference. This report pulls together the conversations at the roundtable and distils the key findings.

Limiting global warming to ‘safe’ levels will require rapid and radical reductions of greenhouse gas emissions across all sectors of the global economy. The discontinuation of incumbent industrial structures, that will be an unavoidable part of such sustainability transitions, will disproportionally burden certain groups. Recent events including the social and political unrest linked to the immine

Current research offers very limited insights on the process of how the adoption and continued use of cloud sourcing might trigger and push the development of business model innovation and affect the competitive advantage of a firm. Applying an abductive approach, with two longitudinal case studies of cloud sourcing firms, and a theoretical framework based on stage-based models of business model i

Context: Digitalization brings new opportunities and also challenges to software companies.Objective: Software companies have mostly focused on the technical aspects of handing changes and mostly ignoring the business model changes and their implications on software organization and the architecture. In this paper, we synthesize implications of the digitalization based on an extensive literature s

In market-driven product development, it is important that the software product is released to the market at the right time, and offers higher quality than the competitors. In release planning, the allocation of development effort in investments into product enhancements, functions are competing with quality requirements for limited resources. In addition, it is important to find the right balance

We perform an explorative analysis of employment patterns in the foundationaleconomy producing mundane everyday necessities and providing welfare services across Swedish regional labour markets between 2007 and 2016. We focus specifically on hierarchical patterns in spatial distribution of foundational activities and their association – direct and through integration with other economic activities

Background: The goal of postnatal care is to provide the highest possible quality of care and medical safety with the least possible intervention in order to optimize health and wellbeing of the new family. The aim of the study was to describe mothers´ experiences in relation to a new postnatal home-based model of midwifery care. Methods: The current study uses a cross-sectional mixed method desig

BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood.METHODS: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measu

The Azerbaijan-Armenia war on Nagorno-Karabakh was a serious challenge for the foreign policy of the Islamic Republic in Iran.