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Immunotherapy with intratumoral injection of adenoviral vectors expressing CD40L has yielded positive results in experimental and clinical bladder cancer. We therefore hypothesized that anti-CD40 antibody would be effective in this setting. Agonistic CD40 antibodies were developed as vaccine adjuvants but have later been used as treatment of advanced solid tumors and hematologic cancers. Systemic
The influence of InAs orientations and high-k oxide deposition conditions on the electrical and structural quality of Au/W/Al2O3/InAs metal-oxide-semiconductor capacitors was investigated using capacitance-voltage (C-V) and x-ray photoemission spectroscopy techniques. The results suggest that the interface traps around the conduction band edge are correlated to the As-oxide amount, while less to t
ApoM is mainly associated with HDL. Nevertheless, we have consistently observed positive correlations of apoM with plasma LDL cholesterol in humans. Moreover, LDL receptor deficiency is associated with increased plasma apoM in mice. Here, we tested the idea that plasma apoM concentrations are affected by the rate of LDL receptor-mediated clearance of apoB-containing particles. We measured apoM in
Double ionization following the absorption of a single photon is one of the most fundamental processes requiring interaction between electrons(1-3). Information about this interaction is usually obtained by detecting emitted particles without access to real-time dynamics. Here, attosecond light pulses(4,5), electron wave packet interferometry(6) and coincidence techniques(7) are combined to measur
The cell wall has long been acknowledged as an important physical mediator of growth in plants. Recent experimental and modelling work has brought the importance of cell wall mechanics into the forefront again. These data have challenged existing dogmas that relate cell wall structure to cell/organ growth, that uncouple elasticity from extensibility, and those which treat the cell wall as a passiv
We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to as
OBJECTIVES: We assessed pharmacodynamic (PD) response for the reduced prasugrel 5-mg maintenance dose in very elderly (≥75y; VE) patients. BACKGROUND: In TRITON-TIMI 38, prasugrel 10-mg reduced ischemic events versus clopidogrel 75-mg, but increased bleeding in VE patients. METHODS: We examined PD and active-metabolite pharmacokinetics with prasugrel 5-mg and 10-mg and clopidogrel 75-mg in a three
Lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) are associated with erectile dysfunction. Alpha-1-adrenoceptor antagonists are effective drugs for treating symptomatic BPH. Clinical data show improvements in LUTS by phosphodiesterase 5 inhibitors. This study aimed to evaluate effects of silodosin, a highly selective α1A-adrenoceptor antagonist, alone or in combin
Psychiatric, physical and biological aspects of posttraumatic stress disorder (PTSD) may be associated with dysfunctions in several cellular processes including nitric oxide (NO) production. NO is synthesized from arginine in a reaction carried out by NO synthase (NOS) enzymes. The recently introduced "global arginine bioavailability ratio" (GABR; ratio of arginine to [ornithine+ citrulline]) has
This study aims to evaluate the direct effects of anthropogenic deforestation on simulated climate at two contrasting periods in the Holocene, similar to 6 and similar to 0.2 k BP in Europe. We apply We apply the Rossby Centre regional climate model RCA3, a regional climate model with 50 km spatial resolution, for both time periods, considering three alternative descriptions of the past vegetation
A paradigm shift is emerging in universities especially regarding how personalized and collaborative mobile learning should be addressed. Recently three international benchmarking projects on quality of e-learning in higher education have been carried out by Lund University in Sweden. These showed that quality has to be valued from a holistic perspective and to a higher extent from learning dimens
Due to potential benefits of high energy conversion efficiency and low noise/pollution, fuel cells have attracted many application areas. In general, fuel cells can be applied on-board ships as emergency power supply, electric energy generation, power output for propulsion or where appropriate, a combination of these uses. In this paper, a brief summary is presented for various fuel cells and thei
Abstract is not available
Sammanfattningsvis kan vi konstatera att den tekniska utvecklingen avseende IT-hjälpmedel och bostadsanpassningar för de närmaste kommande åren inte främst är en teknisk fråga. Visserligen pågår en utveckling av tekniska tillämpningar med stor potential a
Authorship, anonymity and the liberty of the press in Denmark in the eighteenth century: By using the national bibliography of Denmark it is possible to get an impression of change in matters of anonymity and authorship from the eighteenth to the nineteenth century. Furthermore, a case study of the poet, 'nouvelliste' and pamphleteer Jacob Christian Bie sheds light on conditions for writing and pu
