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Model systems have shown that adenoviral vector mediated transient gene expression can potentially be applied for the treatment of brain tumours, neurodegenerative diseases and brain injuries. Most studies utilized adenovirus serotype 5 (Ad5) based vectors, which as adhesion molecules require the coxsackie adenovirus receptor (CAR) as a critical determinant for cellular infection. In this report,

Experiments were conducted to study the energy efficiency of the impulse unit in the pilot-scale research paper machine at the Swedish Pulp and Paper Research Institute (STFI) In Stockholm, Sweden. The paper produced was made of kraft softwood pulp with basis weights of 60-120 g/m(2). The roll surface temperature ranged from ambient temperature to 350 degreesC and the press loads were between 400-

Objective. Increasing survival of extremely low birth weight (ELBW; birth weight < 1000 g) infants raises a concern regarding the risks of adverse long-term outcome such as cognitive dysfunction. Few studies have reported long-term follow-up of representative regional cohorts. The objective of this study was to assess the 5-year outcome of a prospectively followed national ELBW infant cohort. Meth

Apolipoprotein ( apo) M is a novel apolipoprotein belonging to the lipocalin protein superfamily, i.e. proteins binding small lipophilic compounds. Like other apolipoproteins, it is expressed in hepatocytes and secreted into plasma where it associates with high-density lipoprotein particles. In addition, apoM is expressed at high levels in the kidney tubule cells. In this study, we show that the m

The basic electrochemistry of carbon paste electrodes modified with two new redox mediators, nitro-fluorenone derivatives, one neutral and one negatively charged, adsorbed on zirconium phosphate has been studied as well as their ability to oxidize NADH electrocatalytically. Cyclic voltammetry of these chemically modified electrodes performed in different aqueous buffer solutions at different pHs r

The fusion-evaporation reactions Si-28(S-32,1 alpha 2p1n)Fe-53 at 125 MeV and Mg-24(S-32,2p1n)Fe-53 at a 95-MeV beam energy were used to investigate excited states in Fe-53. The combination of the Gammasphere Ge detector array and ancillary devices led to the construction of an extensive level scheme comprising some 90 transitions connecting 40 states. The lifetime of the yrast 25/2(-) state and u

Background. Splenectomy is accompanied by a life-long risk of overwhelming postsplenectomy infection (OPSI), mainly caused by polysaccharide (PS) encapsulated bacteria such as Streptococcus pneumoniae. Despite extensive prophylactic efforts the mortality and morbidity rates remain high. The present study was based on a strategy with a predefined vaccination algorithm including repeated 23-valent p

The influence of the sorbent preparation protocol and separation parameters on the selectivity and chromatographic efficiency of super-porous molecularly imprinted polymer (MIP) monoliths in capillary electrochromatography (CEC) was studied. Chiral templates were employed and enantiomer separation and resolution were used as measures of imprint selectivity and column efficiency, respectively; the

Forty patients who had had a patellar fracture during the years 1950-58 were reevaluated 30 years later. A clinical and radiographic examination was performed. Fourteen patients had subjective complaints. Two thirds of the patients who had more than 2-mm diastasis or 1-mm incongruity had complaints and reduced quadriceps strength. Radiographically, all the patients had a reduction in the lateral p

Natural radiative lifetimes and LandégJ factors for several highly excitedF states in cesium were measured using time-resolved fluorescence spectroscopy. TheF states were excited from the 52D5/2 state with a pulse-modulated CW dye laser, and the delayed-coincidence method was employed to record decay curves, which in some experiments exhibited Zeeman quantum beats. A further CW dye laser was used

Graft polymerization using potassium diperiodatocuprate as initiator was found to be an effective and convenient method for grafting functional polymer of N,N-dimethylaminoethyl methacrylate (DMAEMA) onto superporous polyacrylamide gels, so-called cryogels (pAAm cryogels). It was possible to achieve grafting degrees up to 110% (w/w). The two-step graft polymerization i.e. first activation of the m

Aim: To document the effects of indomethacin (IND) on coronary flow. Methods: We studied nine premature lambs during the first day of life. The gestational age varied between 132 and 134 days (term 145 days) and weight 3.1-4.7 kg. Coronary flow velocities were recorded with an intracoronary Doppler guide wire in the proximal left anterior descending coronary artery (LAD). Average peak flow velocit

A model of motion and direction detection is presented as well as results from a computer simulation of the model. The model is based on cooperative computations which allows an extremely simple architecture. Furthermore, it involves only one logical step in its computations even though Hubel and others have argued that motion detection requires at least two. This is made possible by not including

Popular Abstract in Swedish Avhandlingen handlar om litteraturläsning och litteraturundervisning i grundskolan. Syftet är att belysa den betydelse läsning av skönlitteratur ges i skolans mellanår i början av det tjugoförsta århundradet. Forskningsfrågorna berör de mål och föreställningar om litteratur och läsning som lärare ger uttryck för och hur dessa kommer till uttryck i konkret klassrumsarbetThis dissertation explores the teaching of literature in Swedish compulsory school. The aim of the study is to elucidate different approaches to literature instruction in upper elementary school (grades 4-6, pupils aged 10-13). The research questions focus on what goals and ideas about literature and reading guide teachers and how these are carried out in pedagogical practice and classroom activit