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Down-regulation of apolipoprotein M expression is mediated by phosphatidylinositol 3-kinase in HepG2 cells.

Apolipoprotein M (apoM) is a novel apolipoprotein present mostly in high-density lipoprotein (HDL) in human plasma. In the present study, we demonstrate that insulin, insulin-like growth factor I (IGF-I), and IGF-I potential peptide (IGF-IPP) significantly inhibits apoM expression, in a dose- and a time-dependent manner, in the human hepatoma cell line, HepG2 cells. Insulin-induced down-regulation

Master's Theses in Automatic Control 1965-1970 (Examensarbeten 1965-70)

Abstracts of all master theses, made at the Division of Automatic Control, Lund Institute of Technology, are collected in this report. The theses, made from 1965 until July, 1, 1970, are ordered chronologically. The report is mainly written for other research institutes in the field of automatic control, industries, individual researchers as well as future candidates for master theses. The purpose

Phosphatidylethanol affects inositol 1,4,5-trisphosphate levels in NG108-15 neuroblastoma x glioma hybrid cells

Phosphatidylethanol is formed by phospholipase D in animal cells exposed to ethanol. Previous reports have demonstrated that the degradation of phosphatidylethanol is slow, indicating that this lipid may be present in the cells after ethanol itself has disappeared. Accumulation of an abnormal alcohol metabolite may influence cellular functions. In the present study, cultivation of NG108-15 neurobl

TMD in relation to malocclusion and orthodontic treatment - A systematic review

Objective: The aim of this systematic literature review was to evaluate associations between different malocclusions, orthodontic treatment, and signs and symptoms of temporomandibular disorders (TMD). Materials and Methods: This review was part of a project at the Swedish Council on Technology Assessment in Health Care focusing on malocclusion and orthodontic treatment from a health perspective.

No evidence of association of the PDCD1 gene with Type 1 diabetes

Aims To test the association between the immunoreceptor PD-1 (PDCD1) gene and Type 1 diabetes mellitus (T1DM). This gene has been reported to be associated with other autoimmune diseases such as systemic lupus erythematosus (SLE) as well as T1DM. Methods Genotyping of single nucleotide polymorphisms (SNPs) in the PDCD1 gene was performed using polymerase chain reaction-restriction fragment length

Mitogenomic analyses provide new insights into cetacean origin and evolution

The evolution of the order Cetacea (whales, dolphins, porpoises) has, for a long time, attracted the attention of evolutionary biologists. Here we examine cetacean phylogenetic relationships on the basis of analyses of complete mitochondrial genomes that represent all extant cetacean families. The results suggest that the ancestors of recent cetaceans had an explosive evolutionary radiation 30-35

Ion channels, electrical activity and insulin secretion

The insulin-secreting pancreatic beta cell is electrically excitable and changes in the membrane potential play an important role in coupling the metabolism of glucose (and other nutrient secretagogues) to the discharge of the insulin-containing granule. The application of the patch-clamp technique, which permits the recordings of the minute currents associated with the opening of individual ion c

Electronic structure of free-standing InP and InAs nanowires

An eight-band k.p theory that does not suffer from the spurious solution problem is demonstrated. It is applied to studying the electronic properties of InP and InAs free-standing nanowires. Band gaps and effective masses are reported as a function of size, shape, and orientation of the nanowires. We compare our results with experimental work and with other calculations.

Autofluorescence of various rodent tissues and human skin tumour samples

Fluorescence spectra from different organs in rats and mice have been recorded to explore the potential of non-intrusive tissue diagnostics. The fluorescence was induced by a nitrogen laser that emitted at a wavelength of 337 nm. Optical multichannel techniques were used for the detection. Spectra are given from 19 different sites in Wistar/Furth rats, including an inoculated malignant tumour. The

Aspects of photoinduction of carotenogenesis in the fungus Verticillium-Agricinum

An action spectrum for light induced carotenogenesis in V. agaricinum (Link) Corda (ATCC 24668) was obtained by exposing mycelial pads to monochromatic radiation. Action maxima occurred at 290 (main peak) and 390 nm and there was a minor peak at 483 nm. An interaction between the blue and UV light occurred. Blue light partly reversed the UV light induction of carotenogenesis when given after, but

Treatment-resistant detrusor overactivity - underlying pharmacology and potential mechanisms.

Bladder function during filling and micturition is regulated by peripheral and central nervous and hormonal control systems. Micturition occurs in response to afferent signals from the lower urinary tract, and distention of the bladder wall is the primary stimulus. In the animal and human bladder, efferent adrenergic, cholinergic and nonadrenergic, noncholinergic (NANC) neurotransmission has been

Self-regulated learning through writing on computers: Consequences for reading comprehension.

The overall aim for the present study was to analyze the consequences for reading ability among the children of a computer supported self-regulated learning environment in grade two. By means of a quasi-experimental design in a natural setting, an experimental group (n=39) was compared to a control group from a national sample (n=3409) on reading comprehension. The statistical analyses showed that

Global sequence and dispersion of ventricular repolarization: In vivo validation of non-invasive parameters using monophasic action potential mapping technique

The purposes are to validate the noninvasive parameters, QT interval, QT dispersion, Tpeak-Tend interval, and the activation recovery time (ART) for estimation of global dispersion of ventricular repolarization (DVR), and to investigate the changes of repolarization sequence and DVR by altered ventricular pacing sites. The material consisted of 12 patients (Study I) and two series healthy pigs wi

Hydrogen Addition For Improved Lean Burn Capability of Slow and Fast Burning Natural Gas Combustion Chambers

One way to extend the lean-burn limit of a natural gas engine is by addition of hydrogen to the primary fuel. This paper presents measurements made on a one-cylinder, 1.6- liter natural gas engine. Two combustion chambers, one slow and one fast burning, were tested with various amounts of hydrogen (0, 5, 10 and 15%-vol) added to natural gas. Three operating points were investigated for each combus

Production of phi mesons at midrapidity in root S-NN=200 GeVAu+Au collisions at relativistic energies

We present the results of phi meson production in the K+K- decay channel from Au+Au collisions at root s(NN) =200 GeV as measured at midrapidity by the PHENIX detector at Brookhaven National Laboratory's Relativistic Heavy Ion Collider. Precision resonance centroid and width values are extracted as a function of collision centrality. No significant variation from the Particle Data Group accepted v

Metastable VO2 complexes in silicon: experimental and theoretical modeling studies

We report on a combined experimental and theoretical study of the metastable form of the vacancy-dioxygen defect in Si labeled VO2*. Important new experimental observations are the 2 detection of mixed local vibrational modes of VO*(2) in O-16, O-18 co-doped samples, the determination of the position of LVM bands for the negatively charged defect, and an assignment of an acceptor level at about E-