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Background: The association between lifestyle factors and Alzheimer's disease (AD) pathophysiology remains incompletely understood. Objective: The aim of this study was to assess the association of alcohol consumption, smoking behavior, sleep quality and physical, cognitive, and social activity with cerebral amyloid pathology. Methods: For this cross-sectional study, we selected participants from
The human blood proteome provides a holistic readout of health states through the assessment of thousands of circulating proteins. In this study, we present a pan-disease resource to enable the study of diverse disease phenotypes within a harmonized proteomics dataset. by profiling protein concentrations across 59 diseases and healthy cohorts, we identified proteins associated with age, sex, and b
Background Inversions involving intron 22 (Inv22) of the F8 gene are detected in approximately 45% of all severe hemophilia A (HA) patients. Digital droplet polymerase chain reaction using milepost assays and multiplex ligation-dependent probe amplification (MLPA) allows robust diagnosis of inversions, copy number variations, and more complex rearrangements in F8 . Objectives A total of 350 HA pat
När föräldrar har låga inkomster minskar barnens möjligheter att exempelvis resa på semester eller delta i fritidsaktiviteter som kostar pengar. Att växa upp i ekonomisk utsatthet kan påverka barns framtidsutsikter negativt. Av den offentliga statistiken vet vi att barnfattigdom är vanligare bland familjer med utrikes födda föräldrar, men variationen inom gruppen är stor och delvis outforskad.I de
This chapter challenges the widespread belief that shopping provides lasting happiness and stress relief. This myth, often referred to as ‘retail therapy’, suggests that consumption serves as an effective coping mechanism for emotional distress. Rooted in post-war consumer culture and reinforced by advertising, this idea has normalised the use of material goods to manage emotions, fostering a depe
In this paper we review the physics opportunities at linear e+e− colliders with a special focus on high centre-of-mass energies and beam polarisation, take a fresh look at the various accelerator technologies available or under development and, for the first time, discuss how a facility first equipped with a technology that is mature today could be upgraded with technologies of tomorrow to reach m
Cardiac magnetic resonance (CMR) with late gadolinium enhancement (LGE) imaging shows myocardial fibrosis and is associated with outcome in repaired Tetralogy of Fallot (rToF). However, patients with rToF have surgical material implanted, also appearing bright in LGE images. Therefore, right ventricular myocardial fibrosis could be overestimated or falsely diagnosed, which may affect prognostic va
The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,The Swedish music and arts school (SAMS) has been described as “a foundation for Swedish culture, where children and youth are given opportunities to express themselves through dance, fine art, drama, music or other art forms” (Öhrman & Holmdahl, 2022, s. 103). Current debates have questioned SAMS capacity to meet contemporary needs, revolving around themes such as broadening of target groups,
I dagens välfärdstjänster har synen på användaren i allt högre grad förskjutits från en passiv mottagare till en aktiv deltagare i värdeskapande. Denna förskjutning återspeglas i policyreformer, organisatoriska strategier och akademisk diskurs, vilka alla i ökande grad betonar användarorientering. Inom det teoretiska ramverket Public Service Logic (PSL) framställs användarorientering som ett sätt In today’s welfare services, how the user is viewed has increasingly been shifting away from a passive recipient towards an active participant in value creation. This shift is reflected in policy reforms, organisational strategies, and academic discourse, with all of these placing a growing emphasis on user orientation. Within the theoretical framework of Public Service Logic (PSL), user orientati
This chapter challenges the widely held belief that more consumer choices lead to better outcomes. This chapter explores how the proliferation of options, while seemingly empowering, can actually lead to decision paralysis, dissatisfaction and unsustainable consumption patterns. The myth is rooted in classical economic theories that equate more choice with freedom and personal satisfaction, but ps
BACKGROUND: HYPO-RT-PC is a phase 3 trial comparing ultra-hypofractionated and conventionally fractionated radiotherapy in intermediate-to-high-risk localised prostate cancer. This 10-year update reports long-term efficacy and toxicity outcomes.METHODS: In this open-label, randomised, phase 3, non-inferiority trial done in ten centres in Sweden and two in Denmark, we recruited men aged 75 years or
We present the characterisation of the TOI-6041 system, a bright (V = 9.84 ± 0.03) G7-type star hosting at least two planets. The inner planet, TOI-6041 b, is a warm Neptune with a radius of 4.55-0.17+0.18 R⊕, initially identified as a single-transit event in TESS photometry. Subsequent observations with TESS and CHEOPS revealed additional transits, enabling the determination of its 26.04945-0.000
Background: Globally, undernutrition is responsible for over 3.5 million deaths among children under the age of 5. In Mozambique, it remains a major contributing factor to the high rates of child mortality and illness. Essential micronutrients like zinc, iron, and calcium play a vital role in healthy growth and development. However, their absorption is hindered by anti-nutrients such as phytates,
High-risk neuroblastoma is characterized by MYCN amplification and high MYCN or MYC gene expression. These patients have a poor prognosis and there is an urgent need for more effective drugs. While strategies to develop inhibitors that directly target the MYC proteins have remained largely unsuccessful, recent preclinical studies have identified ATR, a key protein of the DNA damage response, as a
Studies of the surface chemistry of the first few cycles of atomic layer deposition (ALD) using in situ and time-resolved operando techniques are attractive for realizing, understanding, and obtaining true mechanistic information during the deposition. However, the latter techniques are yet to be applied to ALD of metal nitrides. Here, we present a surface-chemistry investigation through a time-re
Summary: In this meta-analysis of international cohorts, current smoking is confirmed as a significant BMD-independent predictor of future fracture with a stronger relationship in men than in women. A causative and reversible effect of smoking on fracture risk is suggested by past smoking having a significantly lower risk than current smoking. Purpose: In this meta-analysis of international cohort
This thesis consists of three self-contained papers that study the role of culture in economics by examining how culture shapes responses to policies, how public interventions influence cultural identity, and how cultural persistence affects economic behavior and policy outcomes. The first chapter examines the political consequences of symbolic changes to public space in Spain, focusing on the ren
Heat pumps are a key technology for decarbonizing residential heating, yet their diffusion remains limited in many countries, partly due to challenges of public acceptance and legitimacy. This study tracks how heat pumps are portrayed in German public discourse by analyzing sentiment in online news coverage. We compile a corpus of 33,131 German heat pump–related news articles published between 201
