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Background: Despite well-documented evidence demonstrating the efficacy and safety of integrated treatments for post-traumatic stress disorder (PTSD) and substance use disorder (SUD) in adults, few studies have been conducted among adolescents and young adults, developmental periods when these disorders typically have their onset. Objective: This randomized controlled trial compared the efficacy
Treatment decisions in lung cancer rely on comprehensive molecular and histological characterization, but the limited amount of tumor tissue available from diagnostic procedures remains a major challenge. In this proof-of-concept study, we investigated whether preserving small bronchoscopic tumor specimens in RNAlater enables integrated molecular and histological profiling. Bronchial forceps biops
Passive immunotherapy targeting amyloid-β (Aβ) has emerged as a major therapeutic strategy for Alzheimer’s disease (AD), yet its clinical benefits remain modest and are frequently accompanied by vascular adverse events such as amyloid-related imaging abnormalities (ARIA). While the removal of extracellular Aβ plaques is associated with therapeutic efficacy, accumulating evidence suggests that addi
The competition, especially for light, is a fundamental determinant of the structure and composition of a forest. Large-scale forest models must balance real-world complexity with computational demand and poorly constrained parameters. The LPJ-GUESS dynamic global vegetation model has a strong track record of simulating forest composition and tree demography with a simple representation of forest
Climate change accelerates the global hydrological cycle, which has escalating impacts on human health and the socioeconomic development. However, many existing Earth system models neglect the more complex processes of topography-driven vegetation–surface–groundwater interactions, thereby failing to accurately capture climate-hydrological responses. To address this gap, we integrate the three-dime
The vertebrate retina is a uniquely complex and evolutionarily conserved structure, combining ciliary (rod and cone) and rhabdomeric (ganglion, amacrine and horizontal cells) photoreceptor lineages within a multilayered circuit. This arrangement contrasts with the ancestral bilaterian cephalic pattern, where rhabdomeric photoreceptors dominate lateral eyes and ciliary photoreceptors are largely li
Student housing as a type of housing is regularly overlooked in architectural historiography and theory. Yet, student housing is a category of housing that an ever-larger portion of society inhabit, albeit for a limited time. Looking more closely at this category of housing reveals that it is a field of study that runs parallel to society’s more general questions of housing whilst also showing var
Abstract in FrenchCet article examine la réception dominicaine de La Croix de Jésus de Louis Chardon dans l’entre-deux-guerres, en s’appuyant sur des sources d’archives inédites, dont une réponse de François Florand à ses critiques restée jusqu’ici non publiée. Il retrace comment la redécouverte de Chardon par Bremond a engagé Garrigou-Lagrange dans une lecture défensive de la mystique thomiste, cThis article examines the Dominican reception of Louis Chardon’s La Croix de Jésus in the interwar period, drawing on unpublished archival sources, including a previously unedited response by François Florand to his critics. It traces how Bremond’s rediscovery of Chardon drew Garrigou-Lagrange into a defensive reading of Thomist mysticism, how Florand’s 1937 edition presented Chardon as a Thomism
PurposeThis research examines the experiences of small and medium-sized enterprises to analyze how Business Model Innovation (BMI) may be facilitated by cluster initiatives and examining the implications of how cluster initiatives can support BMI of SMEs in a lower-middle income country like Bolivia.Design/methodology/approachThis study utilizes a qualitative methodological approach of multiple ca
This paper studies the macroeconomic impact of the Irish bank strike of 1966, which led to the closure of the major commercial banks for three months. We collect a variety of new evidence, such as high-frequency macro data, economic forecasts, micro data and narrative sources. Our findings suggest that the bank strike was associated with a shortfall in economic activity that punctuated a decade of
This paper re-examines Swedish central banking during the interwar period (1924–1939), exploiting major regime shifts to analyze how the Riksbank adapted its core operations. Using monthly money-market data, we show that although interest rate policy broadly followed the ‘rules of the game’ after the return to gold in 1924, the Riksbank’s primary activity—rediscounting commercial bills—was largely
Objective – This study aimed to characterize the occurrence of hypogammaglobulinaemia (HG) in rituximab (RTX)-treated patients with ANCA-associated vasculitis (AAV) in a population-based Swedish cohort. Methods – Patients with incident AAV (1997–2019) in southern Sweden who received RTX for induction or maintenance therapy were included in this study. Medical records were reviewed to assess the in
Cold extremes bring significant uncertainties to the energy system. Their strong spatiotemporal coupling introduces growing challenges to the adequacy and flexibility of the power and heating supply, complicating risk identification and mitigation. Therefore, this paper presents a framework for spatiotemporal risk assessment and resistance enhancement under cold extremes. It captures cold-air prop
