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Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w
Popular Abstract in SwedishMed utgångspunkt i två forskningsfält – strategisk kommunikation och urbanforskning – analyseras och problematiseras Malmös omvandling från arbetarstad till kunskapsstad. Hur har Malmös förändring genomdrivits? Vilka resonemang och föreställningsramar har styrt omvandlingen? Vilka kommunikativa strategier har använts för att projicera den önskvärda (själv)bilden av en kuIncreasingly cities compete for tourist dollars, shoppers, financial investments, know-how and tax-payers by bolstering the cities images as centers of creativity, innovation, knowledge, art, design and so forth. Accelerated and intensified globalization, technological advances, market deregulations,de-industrializations and socio-economic change have urged cities, especially former industrial cit
BACKGROUND: Fetal chronic hypoxia leads to centralization of circulation in order to spare the vital organs brain, adrenals and the heart. This can be documented by Doppler ultrasound. Increased blood velocity in the fetal middle cerebral artery (MCA) is an acknowledged sign of centralization of circulation in chronic hypoxia, and is called brain sparing. AIM: Our aim was to assess the relationshi
A full-rank IC x n matrix G(D) over the rational functions F(D) generates a rate R = k/n convolutional code C. G(D) is minimal if it can be realized with as few memory elements as any encoder for C, and G(D) is canonical if it has a minimal realization in controller canonical form. We show that G(D) is minimal if and only if for all rational input sequences p1 (D), the span of U (D) G (D) covers t
The construction of an urea sensitive device based on a conducting polymer is described. The conducting polymer (polypyrrole) was exposed only to a gas-phase; this led to a significant improvement in its stability. A DC-resistometric measuring principle was used, which required only simple measuring equipment. The device responded rapidly to between 0 and 500 mM urea, with resistance changes of be
This study describes and validates a new method for automatic segmentation of left ventricular mass (LVM) in myocardial perfusion SPECT (MPS) images. This is important for estimating the size of a perfusion defect as percentage of the left ventricle. METHODS: A total of 101 patients with known or suspected coronary artery disease underwent both rest and stress MPS and MRI. A new automated algorith
The photoion excitation spectra of (NO)-N-14 and (NO)-N-15 have been studied in the 105-112 Mn excitation region using high-order harmonic laser spectroscopy. Utilizing the small bandwidth offered by this technique, the natural widths of prominent lines in this region have been measured. These lines originate from interactions between high-lying Rydberg levels converging to the NO+ electronic grou
Our aim was to study whether the in situ natural abundance N-15 (delta(15)N)-values and N concentration of understory plants were correlated with the form and amount of mineral N available in the soil. Also to determine whether such differences were related to earlier demonstrations of differences in biomass increase in the same species exposed to nutrient solutions with both NO3- and NH4+ or to N
Lifetimes on the sub-nanosecond scale for the levels v(2)D(3/2), v(2)F(3/2) and v(2)F(5/2) in the 4d5s5p configuration in Zr II have been measured, using the method of laser-induced fluorescence. Combined with branching fractions obtained with the Lund Ultraviolet (UV) Fourier Transform Spectrometer (FTS), experimental oscillator strengths have been derived. From Hubble Space Telescope/Goddard Hig
