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We used a single adeno-associated viral (AAV) vector co-expressing tyrosine hydroxylase (TH) and GTP cyclohydrolase 1 (GCH1) to investigate the relationship between vector dose, and the magnitude and rate of recovery in hemi-parkinsonian rats. Intrastriatal injections of >1E10 genomic copies (gc) of TH-GCH1 vector resulted in complete recovery in drug-naïve behavior tests. Lower vector dose gave p
ABSTRACT: BACKGROUND: The two-step dilute acid hydrolysis (DAH) of softwood is costly in energy demands and capital costs. However, it has the advantage that hydrolysis and subsequent removal of hemicellulose-derived sugars can be carried out under conditions of low severity, resulting in a reduction in the level of sugar degradation products during the more severe subsequent steps of cellulose hy
A largely extended experimental knowledge of the Cu-61(29)32 nucleus has been obtained from three experiments. Excited states in Cu-61 were produced via the fusion-evaporation reaction Si-28(Ar-36, 3p)Cu-61. In addition to the Ge array GAMMASPHERE, neutron and charged-particle detectors placed around the target position were used for high-performance particle spectroscopy. The constructed level sc
The visual semiotics of Groupe µ and its relevance for art theory at large.
Aims. We seek to provide 2MASS and OGLE identifications and coordinates for all stars in the finding chart published by Arp (1965, ApJ, 141, 43). This chart covers the low extinction area around NGC 6522, also known as Baade's window, at coordinates (l, b) = (1.02, -3.92). Methods. A cross correlation, using numerical techniques, was performed between a scan of the original finding chart from Arp
We study the spectral and magnetic properties of one-dimensional lattices filled with 2-4 fermions (with spin-1/2) per lattice site. We use a generalized Hubbard model that takes into account all the interactions on a lattice site, and solve the many-particle problem by exact diagonalization. We find an intriguing magnetic phase diagram which includes ferromagnetism, spin-1 Heisenberg antiferromag
In respons to the grim realities of the present world, Jewish thought has not tended to retreat into eschatological fantasy, but rather to project utopian visions precisely onto the present moment, envisioning redemptions that are concrete, immanent, and necessarily political in nature. The purpose of this book is to contribute to the deeper understanding of the relationship between Jewish thought
Background: Age, gender and socioeconomic status have been shown to be associated with the use of prescription drugs, even after adjustment for multimorbidity. General practitioners have a holistic and patient-centred perspective and our hypothesis is that this may reflect on the prescription of drugs. In Sweden the patient may seek secondary care without a letter of referral and the liability of
History Reborn inFree Competition: The Czech and Slovak Post-communist Transitions and Their Dominant Historical Narratives Two of the four historical narratives presented here, the Czech national-liberal narrative and the Slovak national-European narrative, imbue Czech and Slovak history with national and democratic meaning, by using history to legitimize future aims in these areas. The two rema
Invasive infections remains one of the leading causes of death due to infections over the world, and efficient treatment remains elusive. One of the major causes of sepsis and other invasive infections is pathogenic streptococci that cause a wide range of clinical manifestations in humans. Group A and group G streptococci have both been shown to cause both infections of milder ranges as well as se
The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through alpha V be
We present a novel design for a macrostructured cathode that can be coated with a thin layer of the B-10 solid converter and mounted to replace the Boron-lined flat parallel plates of a proportional counter used for slow neutron detection. The proposed design consists of a 3D regular pattern exhibiting millimeter deep grooves with an opening angle of alpha = 45 degrees, which could be created in t
Thin films of (B4C)-B-10 have shown to be very suitable as neutron-converting material in the next generation of neutron detectors, replacing the previous predominantly used He-3. In this contribution we show under realistic conditions that (B4C)-B-10 films are not damaged by the neutron irradiation and interactions, which they will be exposed to under many years in a neutron detector. 1 mu m thic
This column examines the texture cache, an essential component of modern GPUs that plays an important role in achieving real-time performance when generating realistic images. GPUs have many components and the texture cache is only one of them. But it has a real impact on the performance of the GPU if rasterization and memory tiling are set up correctly.
The solvolysis of substituted benzoyl chlorides is sensitive both to substituent electronic effects and to medium effects. The solvolysis reactions of substituted benzoyl chlorides have been analyzed in the presence of nonionic micelles. The reaction is inhibited or catalyzed depending on the reaction mechanism, dissociative or associative, respectively. The micellar effects observed can be relate
