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Evidence is presented to show that the presence of a channelled reaction branch in a coupled two-enzyme reaction leads to a slower overall relaxation of the system towards steady state following perturbations of the reaction conditions. A predominant part of the total reaction flux change resulting from perturbations may be governed by transients that are more rapid in the presence than in the abs

Eutrophication and persistent pollutants are two of the main environmental problems in European marine and freshwater ecosystems. As they tend to co-occur, interactive processes between eutrophication and contaminants are suggested, that may lead to environmental effects that cannot be predicted from each process alone. In order to predict the consequences of remedial measures (changing the input

Recurrent major depressive disorder with regular seasonal patterns, commonly known as seasonal affective disorder (SAD), has evoked substantial research in the last two decades. It is now recognised that SAD is a common condition with prevalence rates between 0.4% and 2.9% of the general population, and that patients with SAD experience significant morbidity and impairment in psychosocial function

The quark mixing matrix is parameterised such that its "Cabibbo substructure" is emphasised. One can choose one of the parameters to be an arbitrarily chosen angle of the unitarity triangle, for example, the angle beta (also called Phi(1)).

Functional data analysis is used to examine articulatory variability across repetitions in normal speech, under different movement constraints. A temporal normalization technique is applied to align trajectories of lips, jaw, and tongue in vowel-consonant-vowel sequences. Next, an index of amplitude variability is computed, defined as the mean standard deviation between peak velocities of the cons

Analys av tv-serien Dr Whos utveckling till brittisk-amerikansk samproduktion

a mathematically rigorous definition of the one-dimensional Schrodinger operator -d(2)/dx(2)-gamma/x is given, It is proven that the domain of the operator is defined by the boundary conditions connecting the values of the function on the left and right half-axes. The investigated operator is compared with the Schrodinger operator containing the Coulomb potential -gamma/x.

Vascular damage induced by trauma, inflammation, or infection results in an alteration of the endothelium from a nonactivated to a procoagulant, vasoconstrictive, and proinflammatory state, and can lead to life-threatening complications. Here we report that activation of the contact system by Salmonella leads to massive infiltration of red blood cells and fibrin deposition in the lungs of infected

OBJECTIVE: To examine possible estrogen dependent endometrial expression of MMP-26 in vitro. DESIGN: Experimental study. SETTING: Department of Obstetrics and Gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden. METHODS: We studied MMP-26 mRNA in 14 normal endometrial sample

The effects of polyamines were investigated in strips of smooth muscle from guinea pig ileum permeabilized with beta-escin (0.005%). Spermine (1 mM) inhibited transient contractions induced in Ca(2+)-free medium by carbachol (0.1 mM) and GTP gamma S (0.1 mM) but potentiated responses to caffeine (20 mM) and D-myo-inositol 1,4,5-trisphosphate (40 microM). At high ethylene glycol-bis(beta-amino-ethy

Fibril formation of islet amyloid polypeptide (IAPP) is associated with cell death of the insulin-producing pancreatic beta-cells in patients with Type 2 Diabetes Mellitus. A likely cause for the cytotoxicity of human TAPP is that it destroys the barrier properties of the cell membrane. Here, we show by fluorescence confocal microscopy on lipid vesicles that the process of hIAPP amyloid formation