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Precision medicine for complex diseases uses individual-level characteristics to improve prediction of risk, therapeutic response and prognosis. Many precision medicine studies leverage existing data types and analytic methods to reveal new insights; however, beyond oncology, there has been limited success in translating precision medicine research for complex diseases into clinical practice. Thus
Background: Climate change is emerging as a major global health crisis, escalating occupational hazards across all sectors and exacerbating social inequalities. Workers, especially those in outdoor, informal, and precarious employment are increasingly exposed to multiple hazards, leading to adverse physical and mental health outcomes, productivity losses, and premature death. Objective: This comme
Background A valid definition of severe heart failure (HF) is essential for earlier identification, timely referral for advanced therapies, and to optimize clinical trial design. Objectives To assess the prevalence, prognostic performance, and 1-year outcomes associated with different definitions of severe and advanced HF (AdvHF) in patients with heart failure with reduced ejection fraction (HFrEF
Coastal dunes provide critical flood protection for low-lying coastal areas, raising the question of whether these defenses can be maintained in a future climate. Dune development is driven by interactions between sediment transport and vegetation growth. Both processes are affected by climate, notably changes in precipitation. However, tools to assess future precipitation impacts on dune developm
This study develops a framework for investigating the spatiotemporal variability of dust storm (DS) susceptibility in a major DS source in the Middle East i.e., Tigris-Euphrates River Basin. Visual interpretation of true color composites of MODIS satellite images was used to identify DS sources during period 2000-2021. In total 1,028 dust storm sources were identified. Incorporating 70% of DS sour
Objectives To describe the nature of geriatric medical admissions to teaching hospitals in three countries in Africa (Nigeria, Sudan, Tanzania) and compare them with data from the United Kingdom. Design Cross-sectional cohort study. Setting Federal Medical Centre, Idi-Aba, Abeokuta, Nigeria; Soba University Hospital, Khartoum, Sudan; Kilimanjaro Christian Medical Centre, Moshi, Tanzania; and North
Hereditary spastic paraplegias (HSP) are the second most common type of motor neuron disease recognized worldwide. We investigated a total of 25 consanguineous families from Sudan. We used next-generation sequencing to screen 74 HSP-related genes in 23 families. Linkage analysis and candidate gene sequencing was performed in two other families. We established a genetic diagnosis in six families wi
We demonstrate the first fully vertical single-fin AlGaN FinFETs (Al = 2.5%) on ammonothermal n+-GaN substrates, featuring a gate length of Lg = 200 nm and excellent gate control. This work presents a systematic study of the impact of fin orientation along the a- and m-crystallographic planes on the electrical performance of AlGaN vertical FinFETs. We report that threshold voltage is maximized at
Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically >3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (i.e., absence of a sustained systolic blood pressure drop >20mmHg with upright posture). 1-10 More recently
In this article I rethink international migration law by analysing the Model International Mobility Convention (MIMC) through a concrete-utopian lens. Starting from the premise that coloniality remains an active structure of the global order, I show how progressive legal projects often reproduce the hierarchies they seek to overcome. Combining Gary Wilder’s concrete utopianism with Ruth Levitas’s
PURPOSE: To elucidate the pathophysiology of the carotid sinus reflex in a large cohort of patients with suspected reflex syncope.METHOD: We reviewed an electronic database of patients with suspected reflex syncope who underwent carotid sinus massage. The diagnostic protocol included both right and left massage, in supine and upright positions, followed by tilt testing.RESULTS: The cohort included
Multiple-choice tests are the gateway to important professional outcomes in the Spanish health sector. Every year, thousands of nursing, psychology, pharmacy, and biology graduates take a multiple-choice test, with wrong answers penalized, in order to access an intern position in a hospital. In such tests, willingness to guess, the decision to provide an answer instead of omitting the question can
Kritiken som har riktats mot regeringens angiverilag är högst befogad – förslaget innebär i praktiken att offentliganställda görs till gränspoliser, menar fyra forskare från universitet och högskolor i Lund, Malmö och Stockholm.En samförfattad debattartikel inom forskningsprojektet HUMASP, av Christina Johnsson, lektor i offentlig rätt och mänskliga rättigheter vid Malmö universitet. Jacob Lind, l
I detta kapitel i boken Geografisk information Behandling beskrivs och behandlas metoder för hur geografisk data analyseras. Kapitlet omfattar såväl geografisk teori som exempel på tillämpningar. Geografisk informationsbehandling baseras på insamling, lagring, analys och visualisering av geografiska data, vilket också är bokens struktur. Denna åttonde upplaga av boken har uppdaterats med aktuella
In response to recent observations from JWST and Atacama Large Millimeter Array, we explore a new class of dynamically self-consistent models that mimics a plausible progenitor of the Milky Way over a wide range of disk gas fractions, fgas. The high gas surface densities encourage vigorous star formation, which in turn couples with the gas to drive turbulence. We show that this coupling through mo
