OBJECTIVE: To investigate feasibility and target engagement of high-dose, add-on pramipexole treatment in anhedonic depression.METHOD: In this open-label pilot study, we included 12 patients with unipolar or bipolar, moderate-to-severe depression and with significant anhedonia symptoms. All patients were on a stable dose of one or a combination of antidepressants and/or mood stabilizers and receiv

OBJECTIVE: To investigate plasma levels of circulating cell-free mitochondrial DNA (ccf-mtDNA) in patients with social anxiety disorder (SAD) and healthy controls (HC).METHODS: In this study, 88 participants (46 patients with SAD and 42 HCs) were enrolled and both ccf-mtDNA and peripheral blood mononuclear cells (PBMC) mtDNA copy number (mtDNA-cn) were measured at up to three times per individual

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that exhibits patterns of usual interstitial pneumonia with honeycombing. IPF is characterized by damaged distal lung epithelium with excessive tissue scarring and extracellular matrix remodeling. The etiology of IPF is unknown and current therapies cannot end or reverse disease progression. Aberrant reactivation of developmental pathways is e

Inom nuvarande könsnormer så ses kön främst som ett uttryck av biologiska könsgrupper som är binära och olika, men kompletterande. En performativ syn på kön analyserar i stället kön som något som uppstår under sociala interaktioner genom konstant repetition av handlingar som sker inom förhärskande könsdiskurser. Dessa hegemoniska könsdiskurser konstruerar kön som fundamentalt heterosexuellt. DärmeCurrent gender norms predominantly construct gender as an expression of binary sex categories that are different but complementary. A performative view of gender instead analyses gender as an emergent feature of social interactions that is created by the constant repetition of acts in relation to discourses of gender. Within these hegemonic discourses, gender is constructed as fundamentally hetero

To mitigate the climate change-induced water shortage and realize the sustainable development of agriculture, drip irrigation, a more efficient water-saving irrigation method, has been intensively implemented in most arid agricultural regions in the world. However, compared to traditional border irrigation, how drip irrigation affects the biophysical conditions in the cropland and how crops physio

Plastic film mulching (PFM) in the cropland may alter biophysical conditions for crop growth, which may not be accounted for in existing stomatal conductance models. This can affect the accuracy of carbon–nitrogen-water cycle simulations for the soil-crop systems and hamper our understanding of internal mechanisms that control plant leaf stomatal conductance (gsw). To evaluate the simulations of P

The phase behavior of some different colloid systems is reviewed. Starting off with polymer solutions, we recall that while the monomers are soluble in the solvent, the polymer may not. Two polymers are even less miscible. Block copolymer melts, formed by two immiscible blocks, undergo “microphase separation” and form ordered liquid crystalline phases. Colloidal spheres crystallize at higher conce

This paper investigates the outcomes of small-scale egalitarian language contact in an attempt to address whether different linguistic domains exhibit different degrees of stability and resistance to convergence among cohabitant speakers of Jahai and Jedek, two closely related Aslian (Austroasiatic) language varieties spoken in northern Peninsular Malaysia. Using nonparametric Bayesian mixture mod

According to conventional wisdom, improving energy efficiency is an easy way to mitigate climate change and improve energy security, though the reduction in energy intensity in developed economies is largely due to offshoring energy-intensive production to developing countries. This chapter presents a contrarian view. Theory, historical evidence, and time series analysis suggest that the economy-w

Machine learning methods are now ubiquitous in physics, but often target objectives that are one or two steps removed from our physics goals. A prominent example of this is the discrimination between signal and background processes, which doesn’t account for the presence of systematic uncertainties – something crucial for the calculation of quantities such as the discovery significance and upper l