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Using long-term organ cultures of rat prostate tissue explants, we previously demonstrated that PRL both stimulates proliferation and acts as an androgen-independent suppressor of apoptosis in prostate epithelial cells, leading to epithelial hyperplasia. In this work we delineate intracellular signaling molecules activated by PRL in prostate tissue to identify candidate signaling proteins that are
Stroke poses a massive burden of disease, yet we have few effective therapies. The paucity of therapeutic options stands contrary to intensive research efforts. The failure of these past investments demands a thorough re-examination of the pathophysiology of ischaemic brain injury. Several critical areas hold the key to overcoming the translational roadblock: (1) vascular occlusion: current recana
Abstract (1/2-em) Two-phase systems consisting of a polymer rich phase and polymer depleted phase, where the polymer is either ethyl(hydroxy ethyl)cellulose (EHEC) or Ucon (a random copolymer of ethylene oxide and propylene oxide), have been studied. Both of these polymers can be separated from an aqueous solution by either temperature increase or addition of cosolutes. The polymers are thermosepa
We have performed photoluminescence spectroscopy on single GaAs nanowires with InAs quantum dots in the form of thin slices of InAs, possibly alloyed with Ga as InGaAs, incorporated into the GaAs. The nanowires were grown by chemical beam epitaxy using gold nanoparticles as catalysts. The photoluminescence measurements showed rich spectra consisting of sharp lines with energies and excitation powe
The effects of an increase in UV-B radiation on growth and yield of maize (Zea mays L.) were investigated at four levels of applied nitrogen (0, 100, 200 and 300 kg ha−1 of N) under Mediterranean field conditions. The experiment simulated a 20% stratospheric ozone depletion over Portugal. Enhanced UV-B and N deficiency decreased yield and total biomass production by 22–49%. High UV-B dose reduced
In this study,a silicon micro immobilised enzyme reactor (mu IMER) has been applied for hydrolysis of maltoheptaose as a model maltodextrin and starch using immobilised otamylase (from Aspergillus oryzae) and glycoamylase (from Aspergillus niger). The influence of several parameters was investigated such as immobilisation chemistry, buffer constituents, pH, temperature, flow rate and substrate con
This paper emphasizes that rights facilitate decentralized use of information and computation. A dynamically efficient adjustment process that solves a private information linear resource allocation problem by a sequential auction of production and trading rights is presented. It is shown that in equilibrium the sequential auction mimics the simplex algorithm in a decentralized way and thereby giv
It is now becoming increasingly clear that free radicals contribute to brain damage in several conditions, such as hyperoxia and trauma. It has been more difficult to prove that free radical production mediates ischemic brain damage, but it has often been suggested that it may be a major contributor to reperfusion damage, observed following transient ischemia. Recent results demonstrate that cereb
Bridge splitting in chloroform of the orthometalated chloro-bridged complex [Pt(mu-Cl)(2-Me2NCH2C6H4)](2) (1), with ethene, cyclooctene, allyl alcohol and phosphine according to 1 + 2L --> 2 [PtCl(2-Me2NCH2C6H4)(L)], where L = C2H4 (3a), C8H14, (3b), CH2CHCH2OH (3c), and PPh3 (4a and 4b) gives monomeric species with L coordinated trans or cis to aryl. With olefins the thermodynamically stable isom
Objective. To determine the validity, reliability, and feasibility of durometer measurements of skin hardness as an outcome measure in clinical trials of scleroderma. Methods. Skin hardness was measured during a multicenter treatment trial for scleroderma using handheld digital durometers with a continuous scale. Skin thickness was measured by modified Rodnan skin score (MRSS). Other outcome data
Background: Health effects and health care seeking were investigated among women in rural Vietnam exposed to physical and/or sexual violence from their partner in the past year. The study was conducted within the framework of the demographic surveillance site in Bavi District, Ha Tay Province in northern Vietnam. Methods: Face-to-face interviews based on a questionnaire developed by the WHO for us
n mechanically ventilated patients, sedatives and analgesics are commonly used to ensure comfort, but there is no documented knowledge about the impact of depth of sedation on patients' perception of discomfort. The aim of this study was, therefore, to investigate the relationship between stressful experiences and intensive care sedation, including the depth of sedation. During 18 months, 313 intu
The aim of this study was to clarify the pathway of electron transfer between the inner membrane components and the periplasmic chlorate reductase. Several soluble c-type cytochromes were found in the periplasm. The optical difference spectrum of dithionite-reduced periplasmic extract shows that at least one of these components is capable of acting as an electron donor to the enzyme chlorate reduc
RILEM Technical Committee 50 - Fracture Mechanics of Concrete, has put forward a proposal for a recommendation for the determination of the fracture energy G//F of mortar and concrete. The significance of G//F in the strength of concrete structures is discussed and it is demonstrated that G//F in some cases, for example for shear failure of beams and slabs without shear reinforcement, is a materia
This study explores the use of environmental management systems for initiating and controlling environmental improvements in the context of supply chain cooperation. It examines how environmental requirements are reaching smaller companies in the electronics supply chain, especially in the light of recent legal changes such as enforcement of the RoHS Directive. It is based on qualitative interview
Loss of the JunB/AP-1 transcription factor induces a myeloproliferative disease (MPD) arising from the hematopoietic stem cell (HSC) compartment. Here, we show that junB inactivation deregulates the cell-cycle machinery and increases the proliferation of long-term repopulating HSCs (LT-HSCs) without impairing their self-renewal or regenerative potential in vivo. We found that JunB loss destabilize
