Altered Functional Connectivity Between the Insula and the Cingulate Cortex in Patients With Temporomandibular Disorder: A Pilot Study.
Background.- Among the most common chronic pain conditions, yet poorly understood, are temporomandibular disorders (TMDs), with a prevalence estimate of 3-15% for Western populations. Although it is increasingly acknowledged that central nervous system mechanisms contribute to pain amplification and chronicity in TMDs, further research is needed to unravel neural correlates that might abet the dev