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Oxidativ stress i celler är en bakomliggande faktor till många dödliga sjukdomar. Detta kan kroppen reglera till en viss del med olika proteiner. Ett av proteinerna är Alfa-1-mikroglobulin (A1M) som kan sänka oxidativ stress i kroppen genom att t.ex binda till fria radikaler och bidra till vävnadsreperation. A1M transkriberas tillsammans med ett annat protein, bikunin, som har anti-inflammatoriska
A system for detecting protein-protein interaction using a bacterial two-hybrid approach, a heterologous expression system in Escherichia coli strain based on adenylate cyclase enzyme reconstitution, was invented twenty years ago (Karimova, et al., 1998, PNAS, 95:5752). Before inventing this system, yeast two-hybrid technology was used for screening putative interaction between either two proteins
Kan sorkar med mutationer slippa undan infektioner? Sjukdomar är ett av de största hoten som alla levande varelser kan utsättas för. Lyckligtvis har alla djur ett immunförsvar som försöker bekämpa dessa sjukdomar. Detta försvar består av många komponenter vars ritningar finns nedskrivna i DNA. Mutationer, som förändrar DNA, kan leda till olika variationer av en gen, och olika varianter kan påverk
Customer Support is usually an expensive service for a lot of companies. At Telavox, a majority of the support tickets are sent via e-mail. A support ticket is sent by a customer, containing a request for support. Support tickets from customers could reveal valuable information. Additional insights can be given by labelling the tickets. Today, employees at the customer support department at Telavo
Room acoustics, as a branch of architectural acoustics, has got more and more attention nowadays. One of the aims of the room acoustics is to develop different method to evaluate the acoustic performance of the rooms and to address human acoustic comfort needs. Meanwhile, the process of reverberation plays an important role in room acoustics, and it is also an evaluation standard of evaluating roo
To catalyse transition toward a more sustainable economy, the European Union is proposing several policy interventions within the regulatory framework governing the financial sector. As part of this effort, a new EU Eco-label policy for green investment funds seeks to (i) facilitate individual investor participation in the sustainable investment market and (ii) increase private sector investments
The purpose with this study was to examine the social interaction between social worker and their clients, with focus on the concept’s treatment, communication and power. The study collected information with help of qualitative interviews, there sex social worker who works with financial aid attended. The empiric of the study present experiences from social workers social interaction with their cl
The current field of object detection and image recognition is huge but not without complications. Processing large amounts of high resolution videos needs powerful hardware and also risks breaching the privacy of those who are recorded. In times of increasing demand for decentralized solutions and stricter privacy protection regulations being put in place a new approach is needed. We present an
Bananpiren means the Banana pier and the name is a remnant from when ships full of bananas unloaded by the docks. The last banana ship left the wharf in the year of 2000 and since then the pier has mainly been used for different types of temporary events. Apart from when those are held, the pier is abandon with only one sheet shed still standing, as a glimpse of the piers former past as a freeport
I denna uppsats ser vi vad som händer när en statlig myndighet som ansvarar för utformning av offentlig miljö implementerar en så kallad liberal demokratiteori. Statens konstråd, som är en myndighet med stor inverkan på den offentliga konsten i Sverige, inledde 2012 ett nytt arbetssätt att föra ut konceptuell och samtida konst från institutioner och gallerier till det offentliga rummet. Deras syn In this essay we see what happens when a government authority which is responsible for designing public space implements a so-called liberal democracy theory. The public art agency of Sweden, a government authority with a big impact on the public art in Sweden, started in 2012 a new approach to bring out conceptual, and contemporary art to the public realm. Their view on art is that it should ques
Climate change is a problem. The power sector will bear the brunt of decarbonisation. The most cost effective pathways of achieving deep decarbonisation involve a diverse portfolio of energy technologies. A considerable body of theory suggests that the composition of finance can influence not only the rate but the direction of technical change by selecting technologies with certain economic characClimate change is a problem. The power sector will bear the brunt of decarbonisation. The most cost effective pathways of achieving deep decarbonisation involve a diverse portfolio of energy technologies. A considerable body of theory suggests that the composition of finance can influence not only the rate but the direction of technical change by selecting technologies with certain economic charac
Plast är en central del av det moderna samhället och har otaliga användningsområden. En av konsekvenserna av detta är att det nu finns 4900 miljoner ton plast i naturen. Denna plast bryts långsamt ner tills partiklarna är på nanometer-nivån, dvs. en miljondel av en millimeter. Vissa plaster i denna storlek är giftiga för akvatiskt djurliv och transporteras upp i näringskedjan. I denna rapport undePlastics play a central role in todays society and its use will only increase. When certain plastics are broken down to a nanometre size they become toxic to some aquatic life. Such plastic particles often undergo aggregation, especially in the aquatic environment. It is therefore of interest to study how different types of aggregation affects the physical characteristics as well as the toxicity o
This study examines minimally altered catchments in Europe and North America in order to determine whether any changes to the dynamics of flooding have occurred due to changes in the climate. By examining the parameters of the Generalized Extreme Value (GEV) distributions of individual catchments it is possible to determine not just if changes in flood patterns have occurred, but also the nature o
Eukaryotic cells employ the RNA interference (RNAi) machinery in the cytosol to downregulate gene expression. Short 21-nucleotide microRNAs (miRNAs) associate with the so-called RNA induced silencing complex (RISC) and hybridize with the target gene’s mRNA, preventing it from being translated into protein. Employing the RNAi machinery with synthetic small interfering RNAs (siRNAs) that mimics the
The last few years have seen a rapid expansion within the area of the Internet ofThings (IoT). For many IoT applications, such as asset tracking and distributedsensor networks, the problem of localization (i.e. determining the physical loca-tion of nodes in the network) is fundamental. For such applications, constraintson size, cost, and power consumption often prohibit the use of GPS. This thesis
With the ongoing climate collapse, there is a need for a capital switch, rerouting investments into low carbon infrastructure. Green bonds are a new financial vehicle aimed to facilitate this transition. Through signaling the issuers’ intent to use the proceeds of the bonds towards environmentally beneficial activities, they increase transparency and allow investors to better calculate risks while
Att studera språket och dess metaforer kan säga mycket om hur vi tänker kring en företeelse. I min undersökning tittar jag, dels genom en metaforanalys, dels genom en enkätundersökning, på hur resemetaforen framställer den som är sjuk i cancer, och hur den sjuke reagerar på denna framställning. Syftet med studien är att undersöka vilka konceptualiseringar av cancern som kommer till uttryck i infor
Natural killer cells are part of the immune system and one of their main functions is to dispose of cancer cells and virus-infected cells. In order to avoid detection by T cells, cancer cells can decrease the expression of MHC I proteins which instead can make them a target for NK cells, making NK cells a suitable for use in therapy. This study sought to investigate the cytotoxic ability of NK cel
