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Airway infections are known to cause exacerbations of allergy and asthma. Tonsils constitute a primary site for microbial recognition and triggering of the immune system in the airways. Human β-defensins (HBDs) are antimicrobial peptides with an important role in this defense. Our aim was to investigate HBD1-3 in tonsillar tissue and their potential role in allergic rhinitis (AR). Tonsils, obtaine
Chemical regulation allows non-in vivo testing (i.e. in silico-derived and in vitro-derived) information to replace experimental values from in vivo studies in hazard and risk assessments. Although non-in vitro testing information on chemical activities or properties is subject to added uncertainty as compared to in vivo testing information, this uncertainty is commonly not (fully) taken into acco
Published studies have reported conflicting results regarding the effects of cinnamon on glucose, lipids and insulin. To gain further insight into the metabolic effects of Cinnamomum cassia we performed randomized, double-blinded placebo-controlled study using euglycaemic-hyperinsulinaemic clamp.
Much of the extant work on brand equity in business markets has focused on predicting brand loyalty as in what brand image elements that make buyers prefer to buy a brand The question what drives buyers to pay more or less for brands has however been somewhat overlooked despite price premium being a distinct and economically important outcome of a favourable brand image In an attempt to answer thi
We study and solve the previously unstudied problem of finding both transmitter and receiver positions using only time of arrival (TOA) measurements when there is a difference in dimensionality between the affine subspaces spanned by receivers and transmitters. Anchor-free TOA network calibration has uses both in radio, radio strength and sound applications, such as calibrating ad hoc microphone a
A low level of phosphoric acid (1% w/w on dry bagasse basis, 160 degrees C and above, 10 min) was shown to effectively hydrolyze the hemicellulose in sugar cane bagasse into monomers with minimal side reactions and to serve as an effective pre-treatment for the enzymatic hydrolysis of cellulose. Up to 45% of the remaining water-insoluble solids (WIS) was digested to sugar monomers by a low concent
For a system with interacting quantum mechanical particles in a one-dimensional harmonic oscillator, a trial wavefunction with simple structure based on the solution of the corresponding two-particle system is suggested and tested numerically.With the inclusion of a scaling parameter for the distance between particles, at least for the very small systems tested here the ansatz gives a very good es
The proposed algorithm aims at helping diabetic patients which use multi-dose injection (MDI) therapy to determine the dose and time of insulin and glucose intakes to stabilize their blood glucose (BG) concentration. The objective is to spend most of the time in normal BG range (70-180 mg/dl). The control was done by minimizing the risk of hypo- and hyperglycemia over the doses and times of insuli
Supporting positive mental health development in adolescents is a major public health concern worldwide. Although several school-based programs aimed at preventing depression have been launched, it is crucial to evaluate these programs and to obtain feedback from participating adolescents. This study aimed to explore adolescents' experiences with a -based cognitive-behavioral depression prevention
Background: Members of the Paired-like homeodomain transcription factor ( PITX) gene family, particularly PITX1 and PITX2, play important roles in normal development and in differentiated cell functions. Three major isoforms of PITX2 were previously reported to be produced through both alternative mRNA splicing (PITX2A and PITX2B) and alternative promoter usage (PITX2C). The proteins derived from
Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.
Abstract is not available
The neurobiological basis and temporal dynamics of communicative language processing pose important yet unresolved questions. It has previously been suggested that comprehension of the communicative function of an utterance, i.e. the so-called speech act, is supported by an ensemble of neural networks, comprising lexico-semantic, action and mirror neuron as well as theory of mind circuits, all act
To be able to disseminate knowledge about maritime safety culture and safety management to different actors in the Swedish maritime sector, a preliminary pedagogical concept was developed and evaluated. As a first user group, students at upper secondary maritime schools were chosen and the pedagogical concept was adapted for this group. The concept includes an interactive prototype and a teacher's
TRIM28 is a corepressor that mediates transcriptional silencing by establishing local heterochromatin. Here, we show that deletion of TRIM28 in neural progenitor cells (NPCs) results in high-level expression of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. We find that NPCs use TRIM28-mediated histone modifications to dynamically regulate transcription and silencing of ERVs, wh
Programmatic vaccination and screening are the reasons for this thesis. The practice of public health incorporating medicine’s cognitive contents along with contributions from other fields of human activities is basically a moral enterprise. It is important that limitations from the whole continuum of these interventions are recognized to retain credibility. The changing demands resulting from the
