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RNA sequencing of human pancreatic islets has provided important insights into the islet transcriptome but little information on the specific cells. In this issue, Segerstolpe et al. (2016) and Xin et al. (2016b) report on the transcriptome of single pancreatic cells from non-diabetic and type 2 diabetic donors.
We analysed the long-term variations in grain-size distribution in sediments from Gåsfjärden, a fjordlike inlet in the southwestern Baltic Sea, and explored potential drivers of the recorded changes in the sediment grain-size data. Over the last 5.4 thousand years (ky) in the study region, the relative sea level decreased 17 m, which was caused by isostatic land uplift. As a consequence, Gåsfjärde
Introduction: This study was aimed to determine the association between PSA levels and biomarkers of subclinical systemic inflammation based on data from 119 middle-aged healthy men from the general population. Materials and Methods: Serum levels of PSA and biomarkers of systemic inflammation (CRP and fibrinogen) were measured. Demographic data were also collected. Subjects were divided into two g
Butterfly eyes are random mosaics built of three ommatidia types, each with a different set of photoreceptors and pigments. What defines the combined features in each ommatidium? A new study has solved the puzzle.
This article presents per capita GDP and income distribution estimates for preindustrial Poland. It is based on a social table for the Voivodeship of Cracow in 1578. Our evidence indicates that income in Poland was distributed more equally than in contemporary Holland. However, the extraction rate was much higher than in the North Sea area. Furthermore, income inequality in the countryside of the
Objective The objectives of this study were to measure socio-economic inequalities in self-reported health (SRH) and healthcare visits and to identify factors contributing to health inequalities among older people aged 50-plus years. Study design This study is based on a population-based, cross-sectional survey. Methods We accessed data of 7150 older adults from the World Health Organization's Stu
Given the current scale of global displacement, in particular from Syria, and the rising death toll of individuals crossing the Mediterranean, the European Union has emphatically stressed the need to work on an effective asylum and immigration policy, through more robust forms of cooperation between Member States. Following the Agenda on Migration in May 2015, a set of new measures and proposals t
This paper examines how governance structures found in the trucking industry impact the coordination between a forwarder and its carriers, including three cases: no forwarder coordination (direct contracting with shippers), investor-owned coordination (price-only contract), and carrier-cooperative coordination (revenue-sharing contract). The carriers are engaged in a Cournot competition, where the
Post-quantum cryptography for resisting possible attacks from malicious quantum adversaries has become one of the key topics in recent cryptographic research. Its ultimate goal is to search for efficient and secure primitives replacing the factoring- and discrete log-based schemes in service that will be broken in polynomial time by Shor’s algorithm. It is now an urgent task to complete this repla
Odonata (dragonflies and damselflies) present an unparalleled insect model to integrate evolutionary genomics with ecology for the study of insect evolution. Key features of Odonata include their ancient phylogenetic position, extensive phenotypic and ecological diversity, several unique evolutionary innovations, ease of study in the wild and usefulness as bioindicators for freshwater ecosystems w
This article focuses on the El Sistema programme, which started up in Sweden in 2010 with the objective to deal with segregation problems typical for Swedish urban areas. The purpose of the article is to examine how promoting integration through music and music education is constructed within El Sistema as a way to help children growing up in multi-ethnic suburbs participate in Swedish society. Th
The structural heterogeneity of tumor tissue can be probed by diffusion MRI (dMRI) in terms of the variance of apparent diffusivities within a voxel. However, the link between the diffusional variance and the tissue heterogeneity is not well-established. To investigate this link we test the hypothesis that diffusional variance, caused by microscopic anisotropy and isotropic heterogeneity, is assoc
The analysis of signals on complex topologies modeled by graphs is a topic of increasing importance. Decompositions play a crucial role in the representation and processing of such information. Here, we propose a new tight frame design that is adapted to a class of signals on a graph. The construction starts from a prototype Meyer-type system of kernels with uniform subbands. The ensemble energy s
The aim of this thesis is to develop statistical models to reconstruct past land cover composition and human land use based on fossil pollen records over Europe for different time periods over the past 6000 years. Accurate maps of past land cover and human land use are needed when studying the interaction between climate and land surface, and the effects of human land use on past climate. Existing
Psykiatrilagsutredningens betänkande behandlar grundläggande frågor om vård, tvång, och straffrättslig ansvarsförmåga. Det handlar bl.a. om vem som kan samtycka till vård och behandling, när samhället kan tillgripa tvång för att förhindra någon från att skada sig själv eller annan. Det handlar också om vem som ska anses har förmåga att bära straffrättsligt ansvar för sina handlingar och de rättsli
I följande rapport redovisar vi resultatet från en utvärdering av datahanteringsplaner genomförd under 2016. Rapporten har följande disposition: bakgrund kring begreppet datahanteringsplaner, syfte och mål, avgränsningar, intressentanalys, risker, metod, resultat från forskarnas utvärdering, resultat från enkät till forskningsfinansiärer och slutligen en sammanfattning och rekommendation.
Rapporten omfattar en omvärldsanalys kring datahanteringsplaner, med analyser från utlandet och Sverige.
In this study the wet adhesion between Layer-by-Layer (LbL) assembled films of triblock copolymer micelles was investigated. Through the LbL assembly of triblock copolymer micelles with hydrophobic, low glass transition temperature (Tg) middle blocks and ionic outer blocks, a network of energy dissipating polymer chains with electrostatic interactions serving as crosslinks can be built. Four tribl
