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Thinking about knowing: conceptual foundations for interdisciplinary environmental research

Working across knowledge-based research programmes, rather than institutional structures, should be central to interdisciplinary research. In this paper, a novel framework is proposed to facilitate interdisciplinary research, with the goals of promoting communication, understanding and collaborative work. Three core elements need to be addressed to improve interdisciplinary research: the types (fo

The enteric nervous system of P2Y13 receptor null mice is resistant against high-fat-diet- and palmitic-acid-induced neuronal loss.

Gastrointestinal symptoms have a major impact on the quality of life and are becoming more prevalent in the western population. The enteric nervous system (ENS) is pivotal in regulating gastrointestinal functions. Purinergic neurotransmission conveys a range of short and long-term cellular effects. This study investigated the role of the ADP-sensitive P2Y13 receptor in lipid-induced enteric neurop

Intensity of factor VIII treatment and inhibitor development in children with severe hemophilia A: the RODIN study

The objective of this study was to examine the association of the intensity of treatment, ranging from high-dose intensive factor VIII (FVIII) treatment to prophylactic treatment, with the inhibitor incidence among previously untreated patients with severe hemophilia A. This cohort study aimed to include consecutive patients with a FVIII activity <0.01 IU/mL, born between 2000 and 2010, and observ

Lipopolysaccharide Interactions of C-Terminal Peptides from Human Thrombin

Interactions with bacterial lipopolysaccharide (LPS), both in aqueous solution and in lipid membranes, were investigated for a series of amphiphilic peptides derived from the C-terminal region of human thrombin, using ellipsometry, dual polarization interferometry, fluorescence spectroscopy, circular dichroism (CD), dynamic light scattering, and z-potential measurements. The ability of these pepti

Chinese university governance: Tensions and reforms

Chinese universities have undergone a massive transformation in recent decades. In addition to a dramatic increase in the number of universities and students, universities have shifted from primarily providing education to emphasizing research. Omnipresent political control is to be replaced by stronger academic self-organization. The result so far is a growing stratification of Chinese universiti

Multiplexed MALDI-MS arrays for screening of MIP solid phase extraction materials.

Technology that facilitates rapid investigation of solid phase extraction protocols using very small amounts of sorbent can save both time and money. The microfabricated ISET (Integrated Selective Enrichment Target) interfaced with MALDI mass spectrometry is able to provide an efficient, economic and generic optimization process for SPE sample preparation. The SPE is performed in a rapid and paral

Exposure to peer deviance during childhood and risk for drug abuse: a Swedish national co-relative control study.

Background. Peer deviance (PD) is associated with risk for drug abuse (DA). Is this association causal? Method. DA was recorded in official records. PD was defined as the percentage of peers residing in small communities with future DA registrations. We examined offspring in families whose community PD changed when the offspring was 0-15 years of age and then examined families where cousins or sib

Extreme storms in Malmo, Sweden

Short-term very intensive storms in the years 1980-2007 from rain gauges in Malmo have been analysed to find intensities of long return periods and to investigate trends. Observations from different stations have been pooled into series to which probability functions have been adjusted. Quality control of short-term precipitation records is emphasized. In order to investigate whether high rain int

Relocating the owl of wisdom : Encyclopaedias in a life-historical perspective

Artikeln undersöker människors förhållningssätt till uppslagsverk och encyklopedier i ett livshistoriskt perspektiv under en period när encyklopedier har genomgått dramatiska förändringar. En frågelista som skickats till fasta så kallade meddelare knutna till Folklivsarkivet i Lund har använts som metod. Svaren har analyserats med hjälp av posthumanistisk teori. Analysen visar de sätt som tryckta Encyclopaedias are artefacts that both define and are defined by the culture in which they are produced and used. Encyclopaedias mirror the time of their creation, at the same time as understanding and use of encyclopaedias is tied to both time and space. From the 19th century until the present day encyclopaedias have changed from exclusive and costly Collections of books kept mainly in libraries

Biochemical characterisation and novel classification of monofunctional S-adenosylmethionine decarboxylase of Plasmodium falciparum

Plasmodium falciparum like other organisms is dependent on polyamines for proliferation. Polyamine biosynthesis in these parasites is regulated by a unique bifunctional S-adenosylmethionine decarboxylase/ornithine decarboxylase (PfAdoMetDC/ODC). Only limited biochemical and structural information is available on the bifunctional enzyme due to the low levels and impurity of an instable recombinantl

Cancer risk in patients with type 2 diabetes mellitus and their relatives.

Epidemiological studies indicate that risks of certain cancers are increased in individuals hospitalized for type 2 diabetes mellitus (T2DM), which may not be representative of the entire population of T2DM patients as most of them are treated in primary health cares. To examine the subsequent cancer risk in individuals with T2DM from hospitals and primary health cares, and in their siblings and s

A Central Role for GRB10 in Regulation of Islet Function in Man.

Variants in the growth factor receptor-bound protein 10 (GRB10) gene were in a GWAS meta-analysis associated with reduced glucose-stimulated insulin secretion and increased risk of type 2 diabetes (T2D) if inherited from the father, but inexplicably reduced fasting glucose when inherited from the mother. GRB10 is a negative regulator of insulin signaling and imprinted in a parent-of-origin fashion

Lentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6

AIM: To investigate the mechanism of interleukin (IL)-6 secretion through blocking the IL-17A/IL-17A receptor (IL-17RA) signaling pathway with a short hairpin RNA (shRNA) in hepatic stellate cells (HSCs) in vitro. METHODS: HSCs were derived from the livers of adult male Sprague-Dawley rats. IL-6 expression was evaluated using real-time quantitative polymerase chain reaction and enzyme linked immun

Short-range structure of proton-conducting BaM0.10Zr0.90O2.95 (M = Y, In, Sc and Ga) investigated with vibrational spectroscopy

The short-range structures of hydrated and dry samples of the proton-conducting, cubic-structured, acceptor-doped perovskites BaM0.10Zr0.90O2.95 (M=Y, In, Sc and Ga), and, for comparison, BaZrO3, have been investigated using infrared and Raman spectroscopy. The results show that the acceptor-doping leads to local structural distortions of the average cubic structure, most likely related to tilts o

U-Pb baddeleyite ages, distribution and geochemistry of 925 Ma mafic dykes and 900 Ma sills in the North China craton: Evidence for a Neoproterozoic mantle plume

Numerous Neoproterozoic mafic dykes, referred to as the Dashigou swarm, are identified in the central and southeastern parts of the North China craton (NCC). They are 305-010 degrees trending dykes, with widths of similar to 10-100 m and exposed lengths of several to >10 km. Precise U-Pb isotope dilution thermal ionization mass spectrometry (ID-TIMS) measurements on baddeleyite grains separated fr

Acupuncture in practice: investigating acupuncturists' approach to treating infantile colic.

Infantile colic is common, but no safe and effective conventional treatment exists. The use of acupuncture has increased despite weak evidence. This practitioner survey explores and discusses how infantile colic is regarded and treated in Traditional Chinese Medicine (TCM). The study is based on personal communication with 24 acupuncturists from nine countries. These acupuncturists specialize in p

NFAT regulates neutrophil recruitment, systemic inflammation and T-cell dysfunction in abdominal sepsis.

The signaling mechanisms regulating neutrophil recruitment, systemic inflammation and T-cell dysfunction in polymicrobial sepsis are not clear. This study explored the potential involvement of the calcium/calcineurin-dependent transcription factor, nuclear factor of activated T-cells (NFAT) in abdominal sepsis. Cecal ligation and puncture (CLP) triggered NFAT-dependent transcriptional activity in