Patients with relapsed and/or refractory multiple myeloma (RRMM) have poor prognosis. The STRATUS study assessed safety and efficacy of pomalidomide plus low-dose dexamethasone in the largest cohort to date of patients with RRMM. Patients who failed treatment with bortezomib and lenalidomide and had adequate prior alkylator therapy were eligible. Pomalidomide 4 mg was given on days 1-21 of 28-day

Background/Objectives:The incidence of microscopic colitis (MC) has increased over the previous decades. In addition to smoking and drugs, currently unidentified environmental factors may have a role. The aim of this study was to determine whether specific dietary or other lifestyle factors were associated with the development of MC.Subject/Methods:The population-based cohort Malmö Diet and Cancer

Objective: The standard surgical treatment of carpal tunnel syndrome (CTS), with an open carpal tunnel release, is reported to relieve symptoms in most patients. In a retrospective observational study, outcome after open carpal tunnel release was evaluated, focusing on factors related to the metabolic syndrome: diabetes, hypertension, obesity (BMI ≥30) and statin treatment. Methods: Results from 4

Background: Antimicrobial stewardship programs have been widely introduced in hospitals as a response to increasing antimicrobial resistance. Although such programs are commonly used, the long-term effects on antimicrobial resistance as well as societal economics are uncertain. Methods: We performed a cost analysis of an antimicrobial stewardship program introduced in Malmö, Sweden in 20 weeks 201

Background: There are knowledge gaps about the life situation for people ageing with Parkinson's disease (PD), with virtually no understanding of home and health dynamics. Therefore, the aim of the present study was to explore the association between aspects of health and objective as well as perceived housing in people with PD. Methods: Participants were recruited from three hospitals in the regi

The emergent nature of the innovation process has always rendered it an elusive subject of study. Nonetheless, academics remained undeterred in their attempts to articulate the innovation process in academics terms as attested by the growing amount of research on the topic. Existing theories for explaining innovation (or the lack of innovation) center on empirical samples from large firms in the h

In this study, a 128 kb ultra low voltage (ULV) SRAM, based on a 7T bitcell with one bitline, is presented. Overall energy efficiency is enhanced by optimizations on all abstraction levels, i.e., from bitcell to macro integration. Degraded performance and reliability due to ULV operation is recovered by selectively overdriving the bitline and wordline with a new single-cycle charge-pump. A dedicat

Lignocellulosic bioethanol from renewable feedstocks using Saccharomyces cerevisiae is a promising alternative tofossil fuels owing to environmental challenges. S. cerevisiae is frequently challenged by bacterial contamination anda combination of lignocellulosic inhibitors formed during the pre-treatment, in terms of growth, ethanol yield andproductivity. We investigated the phenotypic robustness

An on-chip, low power, and area efficient charge-pump (CP) that generates a multiple of the supply voltage (VDD) in a single clock cycle is presented. The proposed CP utilizes parallel cross-connected CP units, which are implemented using MIM (metal-insulator-metal) capacitors. In the target application, i.e., a sub-threshold SRAM, the capacitors are accommodated on top of the memory banks to remo

The overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus gThe overall aim was to investigate informal caregivers providing care for older persons with dementia (≥ 65 years of age) in eight European countries. Focus was on their experiences of formal care, access to support and factors that were associated with caregivers’ psychological well-being and burden. Caregivers’ experiences of formal care were investigated in a qualitative study with four focus g

When a parent is suspected for child abuse, the court in Sweden appoints a lawyer who can decide about the child’s participation in CH without parent’s knowledge or consent. The lawyer brings the child to CH. A familiar person, for example a teacher, accompanies the child. In the study children and their parents are interviewed about their experience and understanding of CH.

Background and aims: Ca2+-induced exocytosis is essential for insulin to be secreted from beta-cells, and in islets from type-2 diabetic (T2D) donors the expression of several genes coding for exocytotic proteins is reduced. Largely this phenomenon cannot be explained by polymorphism; rather it is likely due to epigenetic factors like microRNAs (miRNAs). Indeed, previous studies have identified a

The review presented by Bellomo et al. [1] addresses the modelling approaches employed to represent human behaviour in evacuation in a comprehensive manner. The authors discuss crowd evacuation modelling in light of crisis management, a relevant and current topic given the recent escalation of terrorist threats all over the world. The need for designing buildings for rapid evacuation using crowd e