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AZD0837 is a novel oral anticoagulant investigated in clinical studies for stroke prevention in patients with atrial fibrillation (AF). It is bioconverted to its active form, AR-H067637, a potent, specific and reversible thrombin inhibitor.
Production of chiral amines using omega-transaminases has been thoroughly studied in recent years. Immobilized w-transaminases, however, have been used on relatively few occasions despite potential benefits such as reuse of enzyme and ease of product purification. In this study principally different methods including surface immobilization, entrapment and sweep flocculation using titanium oxide. C
We show that strongly interacting multicomponent gases in one dimension realize an effective spin chain, offering an alternative simple scenario for the study of one-dimensional (1D) quantum magnetism in cold gases in the absence of an optical lattice. The spin-chain model allows for an intuitive understanding of recent experiments and for a simple calculation of relevant observables. We analyze t
Streptococcal toxic shock syndrome (STSS) is associated with a high mortality rate. The M1 serotype of Streptococcus pyogenes is most frequently associated with STSS. Herein, we examined the role of Ras signaling in M1 protein-induced lung injury. Male C57BL/6 mice received the Ras inhibitor (farnesylthiosalicylic acid, FTS) prior to M1 protein challenge. Bronchoalveolar fluid and lung tissue were
The European REACH legislation accepts the use of non-testing methods, such as QSARs, to inform chemical risk assessment. In this paper, we aim to initiate a discussion on the characterization of predictive uncertainty from QSAR regressions. For the purpose of decision making, we discuss applications from the perspective of applying QSARs to support probabilistic risk assessment. Predictive uncert
Oberg CM, Rippe B. Quantification of the electrostatic properties of the glomerular filtration barrier modeled as a charged fiber matrix separating anionic from neutral Ficoll. Am J Physiol Renal Physiol 304: F781-F787, 2013. First published January 9, 2013; doi:10.1152/ajprenal.00621.2012.-In the current study we explore the electrostatic interactions on the transport of anionic Ficoll (aFicoll)
Pulmonary hypertension (PH) due to left heart failure is becoming increasingly prevalent, and is associated with poor outcome. The precise pathophysiological mechanisms behind PH due to left heart failure are, however, still unclear. In its early course, PH is caused by elevated left ventricular filling pressures, without pulmonary vessel abnormalities. Conventional treatment for heart failure may
Directional antennas have been used to solve interference and connectivity issues in wireless networks for some time. Many scenarios have been presented and often positive conclusions are drawn, i.e., showing the increase in capacity. However, to date the research has mainly focused on either antenna placement or transmission scheduling but not the two combined. Such consideration will become incr
To assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of octreotide subcutaneous (sc) depot, a novel octreotide formulation.
This study uses US survey data and Swedish register data to estimate and compare the relationship between returns to schooling and ability. A significant and positive relationship is found for Sweden, but not for the USA. Based on the predictions of the optimal schooling model it is argues that measured differences in the relationship between returns to schooling and ability could depend upon on d
In STEMI, grade-3 ischemia (G3) on admission ECG predicts larger infarct size (IS) than grade-2 (G2). We evaluated whether pre-hospital G3 and its temporal behavior are associated with IS and salvage after pPCI.
Oncolytic immunotherapy with cytokine armed replication competent viruses is an emerging approach in cancer treatment. In a recent randomized trial an increase in response rate was seen but the effect on overall survival is not known with any virus. To facilitate randomized trials, we performed a case-control study assessing the survival of 270 patients treated in an Advanced Therapy Access Progra
Stone pine (Pinus pinea L.) has been widely introduced for afforestation in Mediterranean areas. Despite its wide distribution and its presence since ancient time, it is mostly considered as non-native to the Italian peninsula. Plantation of non-native species may have a strong impact on the soil microbial community and, consequently, on nutrient cycling and soil functions. The effect of stone pin
a1-Microglobulin (a1m) is a 26 kDa plasma and tissue protein belonging to the lipocalin protein family. Previous investigations indicate that the protein interacts with heme and suggest that it has a function in heme metabolism. However, detailed characterizations of the a1mheme interactions are lacking. Here, we report for the first time the preparation and analysis of a stable a1mheme complex up
Patient-specific finite element models have been used to predict femur strength and fracture risk in individuals. Validation of the adopted finite element modelling procedure against mechanical testing data is a crucial step when aiming for clinical applications. The majority of the works available in literature used data from strain gages to validate the model, thus having up to 15 experimental
This work presents an efficient finite element based scheme for the prediction of process properties and especially the material condition of workpiece surfaces after turning. This is achieved by using a database generated with the help of a micromechanically motivated material model - capable of simulating interactions of phase transitions and plasticity - for the efficient post-processing of a m
A measurement of the production processes of the recently discovered Higgs boson is performed in the two-photon final state using 4.5 fb(-1) of proton-proton collisions data at root s = 7 TeV and 20.3 fb(-1) at root s = 8 TeV collected by the ATLAS detector at the Large Hadron Collider. The number of observed Higgs boson decays to diphotons divided by the corresponding Standard Model prediction, c
Allochthonous arthropods can sustain a local food web on seemingly barren land, but are nevertheless often neglected in studies of community assembly. In the present study, we investigated primary food web assembly on nunataks (ice-free areas) in a retreating glacier in Iceland. Nunataks enable studies that take into account both the temporal factor of the assembly and the influx of allochthonous
The influence of the anisotropy of apple tissue and the orientation of applied electric field on electropermeabilization was investigated. Different tissue regions were sampled to perform a series of experiments. The tissue was viewed under the microscope to study cell size, shape and orientation. In a parallel experiment, cylindrical samples of tissue were subjected to pulsed electric fields and
Abstract Phenology is an important part of life history that is gaining increased attention because of recent climate change. We use game theory to model phenological adaptation in migratory birds that compete for territories at their breeding grounds. We investigate how the evolutionarily stable strategy (ESS) for the timing of arrival is affected by changes in the onset of spring, the timing of
