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Laser-induced Fluorescence Studies of Meso-tetra(hydroxyphenyl)chlorin In Malignant and Normal-tissues In Rats

meso-Tetra(hydroxyphenyl)chlorin (mTHPC) is an attractive second-generation dihydroporphyrin photosensitiser for use in photodynamic therapy. In this study, 1.3mgkg(-1) body weight mTHPC was administered intravenously, and laser-induced fluorescence was used to characterise and compare its localisation and retention in different rat tissues, including an induced experimental adenocarcinoma, 24 h a

Looking back at the start of the bone and joint decade what have we learnt?

The Bone and Joint Decade 2000-2010 started as a Swedish initiative in 1996 leading to the UN declaration 1999 followed by the WHO launch 2000. A ten year multidisciplinary and global endeavor moving musculoskeletal conditions onto the research and health agenda is now recognized. Some lessons learned during the journey are presented.

Is Pelvic Floor Muscle Training Effective for Men With Poststroke Lower Urinary Tract Symptoms? A Single-Blinded Randomized, Controlled Trial.

The aim of the current study was to evaluate the effect of pelvic floor muscle training in men with poststroke lower urinary tract symptoms. Thirty-one poststroke men, median age 68 years, were included in this single-blinded randomized controlled trial. Thirty participants, 15 in each group, completed the study. The intervention consisted of 3 months (12 weekly sessions) of pelvic floor muscle tr

Acute pancreatitis - from cellular signalling to complicated clinical course.

Acute pancreatitis (AP) is a common disease that has a mild to moderate course in most cases. During the last decade, a change in diagnostic facilities as well as improved intensive care have influenced both morbidity and mortality in AP. Still, however, a number of controversies and unresolved questions remain regarding AP. These include prognostic factors and how these may be used to improve out

Raman-shifted laser sources suitable for differential-absorption lidar measurements of ozone in the troposphere

Measurements have been performed at eight laboratories on Raman-shifted radiation from frequency-quadrupled Nd:YAG and KrF lasers. Each of these sources is a possible candidate for making differential-absorption lidar measurements of ozone in the free troposphere. The spectral purity, efficiency and divergence of the different sources are compared and explained using a simplified model of the Rama

Structural determinants in the platelet-derived growth factor alpha-receptor implicated in modulation of chemotaxis

Activation of the platelet-derived growth factor (PDGF) beta-receptor leads to cell growth and chemotaxis. The PDGF alpha-receptor also mediates a mitogenic signal, but fails to induce cell migration in certain cell types. To examine this difference in signal transduction, a series of point-mutated PDGF alpha-receptors were analyzed. Porcine aortic endothelial cells expressing mutant PDGF alpha-re

Hadronic collisions in the linked dipole chain model

We apply the Linked Dipole Chain model to hadronic collisions using a modified version of the LDCMC Monte Carlo program. In particular we investigate the effects of multiple scatterings, which in this framework are reformulated in terms of the production of multiple chains of dipoles. We find, among other things, that this way of describing multiple scatterings is less sensitive to the treatment o

Directional stability of an originally straight crack

The directional stability of an originally straight crack under symmetric remote loading is studied after introduction of an infinitesimal disturbance at one or both tips of the crack. The crack is assumed to grow slowly under vanishing mode II stress intensity factor. Directional stability is defined to prevail if the angle formed by the straight line between the crack tips and the original crack

Occupational Risk Factors for Systemic Lupus Erythematosus: a Nationwide Study Based on Hospitalizations in Sweden.

OBJECTIVE: To investigate possible associations between occupation and hospitalization for systemic lupus erythematosus (SLE) in a nationwide study. METHODS: A nationwide database was constructed in Sweden by linking the Swedish Census to the Hospital Discharge Register to obtain data on all first hospitalizations with a primary or secondary diagnosis of SLE in adults during the study period (19

Verapamil Inhibits L-type Calcium Channel Mediated Apoptosis in Human Colon Cancer Cells.

PURPOSE: Treatment with calcium channel blockers have been associated with increased colon cancer mortality in epidemiologic studies. We examined the potential expression and function of calcium channels in two human colon cancer cell lines. METHODS: Both primary (collected at operation) and commercially-available human colon cancer cell lines were used. The colon cancer cells were incubated with