Popular Abstract in English Type 2 diabetes (T2D) is a polygenic disorder characterized by impaired insulin secretion or insulin action in which genes interact with the environment to cause the disease. T2D represent 90% of all patients with diabetes. The disease is increasing globally, with an estimated prevalence of 592 million affected by 2035. According to World Health Organization records, apType 2 diabetes (T2D) is a polygenic disease caused by an interaction between genetic and environmental factors such as low physical activity, smoking, and obesity. The disease is associated with devastating chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) complications. Genome-wide associated studies (GWASs) have been an unbias

Utifrån ett kulturanalytiskt perspektiv undersöker artikeln på vilket sätt ordet andetag används i språket och på vilka sätt det är kopplat till den kroppsliga upplevelsen av att andas. Metaforiskt används ordet andetag synonymt med liv i det svenska språket. Härigenom synliggör ordet de kulturella klassifikationer som finns mellan liv och död. Andetaget är också en del av en kroppslig situation d

The timing of the ice margin retreat of the Late Glacial Patagonian Ice Sheet (PIS) in southern Patagonia has been the object of discussion for many years. In order to resolve questions about the complex response of the PIS to past climate change, any geological interpretation and data modelling need evaluation against an absolute chronology. The aim of this project is to investigate the applicabi

Resistance towards endocrine therapy is a great concern in breast cancer treatment and may partly be explained by the activation of compensatory signaling pathways. The aim of the present study was to investigate if the insulin-like growth factor-1 receptor (IGF1R) signaling pathway was activated or deregulated in breast cancer patients and to explore if any of the markers were prognostic, with or

Neuroblastoma is a childhood malignancy of the sympathetic neuronal lineage. It is a rare disease, but since it is frequently diagnosed during infancy, neuroblastoma causes life-long medical follow up of those children that survive the disease. It was early recognized that a high tumor cell differentiation stage correlates to favorable clinical stage and positive clinical outcome. Today, highly di

The objective of the current study is to investigate the clarification of two high-added value products (pectin containing solution and phenol containing beverage) recovered from olive mill wastewater. For this purpose, both liquids were processed with four types of ultrafiltration (100, 25, 10 and 2 kDa) and one nanofiltration membranes under optimum transmembrane pressure. Retention coefficients

Background: Bronchial smooth muscle cells (BSMCs) from severe asthmatics have been shown to overexpress the Th2-driving and asthma-associated cytokine IL-33. However, little is known regarding factors involved in BSMC production of IL-33. Rhinovirus (RV) infections cause asthma exacerbations, which exhibit features of Th2-type inflammation. Here, we investigated the effects of epithelial-derived m

Few previous publications investigate the possibility of combining multiple waste heat sources in a combustion engine waste heat recovery system. A waste heat recovery system for a HD truck diesel engine is evaluated for utilizing multiple heat sources found in a conventional HD diesel engine. In this type of engine more than 50% of heat energy goes futile. The majority of the heat energy is lost

The modern business environment requires managers to make effective decisions in a dynamic and uncertain world. How can such dynamic decision making (DDM) improve? The current study investigated the effects of brief training aimed at improving DDM skills in a virtual DDM task. The training addressed the DDM process, stressed the importance of self-reflection in DDM, and provided 3 self-reflective

The aim was to assess the risk of venous thromboembolism (VTE) associated with use of combined oral contraceptives (COCs) in women with a family history of VTE.

BACKGROUND:The incidence of invasive disease caused by encapsulated Haemophilus influenzae type f (Hif) has increased in the post-H. influenzae type b (Hib) vaccine era. We previously annotated the first complete Hif genome from a clinical isolate (KR494) that caused septic shock and necrotizing myositis. Here, the full genome of Hif KR494 was compared to sequenced reference strains Hib 10810, cap

Applications of immobilized biocatalysts in both research and industry require highly active catalysts, preferably at a low cost. In this study, cryogels with high catalyst density were produced through cryostructuration of whole Escherichia coli (E.coli) cells. Prepared cryogels are macroporous materials composed of metabolically active cells crosslinked to each other via polymeric structures. Di

Abstract in Norwegian I denne rapporten har vi sett på arbeidsforholdene innenfor gods- og turbilbransjen. Det er bred enighet både på arbeidsgiver- og arbeidstakersiden om at den landbaserte transportnæringen er stilt overfor en rekke utfordringer som følge av økt internasjonal konkurranse de siste tiårene. Det er også en gjennomgående bekymring blant aktørene i både turbil- og godsbransjen for h

The harvesting, utilization and marketing of indigenous fruits and nuts have been central to the livelihoods of the majority of rural communities in African countries. In this study we report on the content of dietary fiber, minerals and selected organic acids in the pulps and kernels of the wild fruits most commonly consumed in southern Mozambique. The content of soluble fiber in the pulps ranged

Surface chemistry and catalysis studies could significantly gain from the systematic variation of surface active sites, tested under the very same conditions. Curved crystals are excellent platforms to perform such systematics, which may in turn allow to better resolve fundamental properties and reveal new phenomena. This is demonstrated here for the carbon monoxide/platinum system. We curve a pla