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The oxidation of methionine residues in proteins to methionine sulfoxides occurs frequently and protein repair by reduction of the methionine sulfoxides is mediated by an enzyme, peptide methionine sulfoxide reductase (PMSR, EC 1.8.4.6), universally present in the genomes of all so far sequenced organisms. Recently, five PMSR-like genes were identified in Arabidopsis thaliana, including one plasti
Aim: Antiepileptic drugs (AEDs) are known teratogens. Some specificity between different AEDs has been noted in the literature. The aim was to compare the teratogenic effect of valproic acid (VPA) and carbamazepine (CBZ) in monotherapy. Methods: Infants exposed to AEDs (n=1398) in early pregnancy were identified from the Swedish Medical Birth Registry. The number of infants with congenital malform
Lack of carbon has been assumed to be the most common limiting factor for bacterial growth in soil, although there are reports of limitation by other nutrients, e.g. nitrogen and phosphorus. We have studied which nutrient(s) limited instantaneous growth rates of bacteria in 28 Swedish soils using the thymidine or leucine incorporation technique to measure increased growth rate after adding differe
The association between medical risk factors and the outcome of foot ulcers was evaluated in 208 consecutive diabetic patients with severe peripheral vascular disease (systolic toe blood pressure < or = 45 mm Hg). All patients were treated and followed by the same foot care team. Eighty patients healed primarily, 83 healed after a minor or major amputation, and 45 died. The systolic toe blood pres
Popular Abstract in Swedish Denna avhandling handlar om hur ljus kan användas för att detektera, diagnosticera och behandla olika medicinska sjukdomstillstånd. Det vi dagligen kallar ljus är bara en liten del av det elektromagenetiska spektret, nämligen den del vi kan uppfatta med våra ögon. Elektromagnetisk strålning med andra våglängder används i stor utsträckning för klinisk diagnostik. RöntgenIn this thesis, different optical methods utilising visible light for characterization of tissue have been developed and evaluated. The feasibility of many of these methods has been demonstrated in the laboratory or in animal experiments. However, the goal is naturally to develop methods useful in the clinic, and thus the emphasis in this thesis has been put on in vivo examinations. Raman spectro
The pharyngoesophageal segment (PES) is a striated muscular structure separating the relatively wide pharynx from the narrow cervical esophagus. There is a substantial axial and longitudinal asymmetry within the PES, as well as basal resting pressure that is substantially influenced by a variety of stimuli as well as deglutition.
The Saccharomyces cerevisiae leukotriene A4 (LTA4) hydrolase (scLTA4 hydrolase) has been crystallized in order to study the two activities of LTA4 hydrolase in an evolutionary perspective. Single well diffracting crystals are obtained after switching from the hanging-drop method to liquid-liquid diffusion in capillaries using PEG 8000 as precipitant. These crystals belong to space group P212121, w
This thesis deals with the information-structural problems native speakers of Swedish have when producing texts in German as their second or foreign language (L2). The study is based on written production data from Swedish learners of German at the initial state (14-year-olds), at intermediate level (16-year-olds) and at advanced level (20-25-year-olds). These data are compared with Swedish and Ge
The complement system involves both the innate and the adaptive immune systems and has important roles in the pathogenesis of SLE. Complement deficiencies within the classical pathway (C1q, C4 and C2) of activation predispose for development of the autoimmune disease SLE. The association between complement deficiencies and SLE could be explained by several mechanisms, including impaired clearance
Biotinylated negatively charged liposomes as well as membranes were affinity partitioned in an aqueous poly(ethylene glycol)-dextran two-phase system using NeutrAvidin conjugated to dextran as affinity ligand. Both liposomes and membranes redistributed from top to bottom phase upon addition of NeutrAvidin-dextran. The presence of 35-60 mM Li2SO4 was necessary both to force the components into the
Group G streptococci (GGS) may be of four different species and may infect humans and also animals. S. dysgalactiae equisimilis most commonly cause human GGS infections. These bacteria are part of the normal flora, but can cause pharyngitis, erysipelas and impetigo. In the immunocompromised host severe conditions, such as sepsis and necrotising fasciitis, may develop. In this thesis the interactio
BACKGROUND--Formoterol and salmeterol are new long acting beta 2 adrenoceptor agonists. The maximum relaxant effect, potency and functional antagonism against carbachol induced contraction for salmeterol, formoterol and salbutamol have been compared in the guinea pig isolated trachea. In addition, the possibility of inducing a non-beta adrenoceptor mediated relaxation by salmeterol was studied. ME
Recension av Paul Hallberg (red.), Per Nyström. Motor i 1900-talets svenska sociala och samhällsekonomiska utveckling. Symposion den 10 november 2003 med anledning av Per Nyströms födelse.
Vid de nivåer av PSA (prostataspecifikt antigen) där en botbar prostatacancer eventuellt skulle kunna diagnostiseras är godartad prostataförstoring vanligare än cancer. Urinvägsinfektioner ger ofta en påtaglig och långvarig ökning av PSA. Vid undersökningsfynd eller symtom som inger misstanke om prostatacancer ska PSA alltid analyseras. Screening med PSA för tidig diagnostik av prostatacancer utvä
When a strong laser field interacts with free atoms, harmonics up to very high orders are created. This extreme ultraviolet (XUV) radiation has interesting properties, such as spatial and temporal coherence, short pulse duration and high brightness. This thesis concentrates on the temporal aspects of this radiation. A method to characterise the pulse duration and time-dependent frequency (chirp)
Staphylococcus aureus isolated from clinically diagnosed cases of toxic shock syndrome (TSS) showed susceptibility to phage types belonging to both I and III groups (90.5%). Phage typing patterns showed a wide diversity among 87 toxic shock syndrome toxin-1 (TSST-1) positive strains isolated from different non TSS clinical sources. Toxin producing strains isolated from both TSS and non TSS showed
Today, driver support tools intended to increase traffic safety, provide the driver with convenient information and guidance, or save time are becoming more common. However, few systems have the primary aim of reducing the environmental effects of driving. The aim of this project was to estimate the potential for reducing fuel consumption and thus the emission of CO, through a navigation system wh
High-resolution transmission electron microscopy characterization of molybdenum oxide catalyst precursors is carried out for a better understanding of the mechanisms leading to the active catalytic material. The precipitated material consists of both large-unit cell crystals and randomly orientated clusters on a 3-5 nm scale. The crystalline clusters are embedded in non-crystalline material, preve
