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Background: The identification of mismatch-repair (MMR) defective colon cancer is clinically relevant for diagnostic, prognostic and potentially also for treatment predictive purposes. Preselection of tumors for MMR analysis can be obtained with predictive models, which need to demonstrate ease of application and favorable reproducibility. Methods. We validated the MMR index for the identification

In recent times, pragmatics has made more and more room for the theory of discourse. The switch in emphasis was triggered, amid other phenomena and theories, by the flourishing pf the communication theory, with its tenet that the process of communication is quite unstable and unpredictable. It is not only the context the one which distorts the transmission of messages, but also the mood of those i

Brain structure and function are tightly correlated across all animals. While these relations are ultimately manifestations of differently wired neurons, many changes in neural circuit architecture lead to larger-scale alterations visible already at the level of brain regions. Locating such differences has served as a beacon for identifying brain areas that are strongly associated with the ecologi

BACKGROUND: A growing body of studies indicate benefits of physiotherapy for patients in palliative care, for symptom relief and wellbeing. Though physiotherapists are increasingly acknowledged as important members of palliative care teams, they are still an underutilized source and not fully recognized. The aim of this study was to explore the variety of activities described by physiotherapists i

OBJECTIVES: To illuminate patterns observed in International Cancer Benchmarking Programme studies by extending understanding of the various influences on presentation and referral with cancer symptoms.DESIGN: Cross-country comparison of Denmark, England and Sweden with qualitative analysis of in-depth interview accounts of the prediagnostic process in lung or bowel cancer.PARTICIPANTS: 155 women

New genus Upretia S. Y. Kondr., A. Thell & J. S. Hur is characterized by partly pruinose, lobate to subsquamulose, olivaceous grey to brown thallus, small ascospores and narrowly bacilliform conidia. It belongs to the subfamily Caloplacoideae of the Teloschistaceae and includes the ‘Caloplaca’ amarkantakana clade. The new genus is closely related to Ioplaca Poelt according to phylogeny analysi

A portrait poem by the German poet Thomas Kling (1957-2005) about the German artist Joseph Beuys is the starting point to reconsider the current ekphrasis discourse in the light of experienced visuality by combining the concept of ancient rhetoric with modern ideas of imagination, multimodality and performativity.

The bone material from three archaeological occupation phases at Huseby Klev provides the best source of evidence currently available about the subsistence strategies of pioneer settlers in Northern Europe. The results from Huseby Klev indicate that the pioneer settlers initially relied heavily on marine mammals for their sustenance. This subsistence strategy changed during the second and third oc

Background--The relationship between "on-treatment" low platelet reactivity and longitudinal risks of major bleeding dual antiplatelet therapy following acute coronary syndromes remains uncertain, especially for patients who do not undergo percutaneous coronary intervention. Methods and Results--We analyzed 2428medicallymanaged acute coronary syndromes patients fromthe Targeted Platelet Inhibition

This book seeks to explore historical changes in the lifeworld of the Mi'kmaq Indians of Eastern Canada. The Mi'kmaq culture hero Kluskap serves as a key persona in discussing issues such as traditions, changing conceptions of land, and human-environmental relations. In order not to depict Mi'kmaq culture as timeless, two important periods in its history are examined. Within the first period, betw

Background: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term changes in blood lipids. Methods: Participants from the GLACIER Study (Nmax = 3492) were genotyped with the MetaboChip array, from which 29 387 SNPs (single nucleotide polymorphisms

A long tradition in research on prehistoric southern Scandinavia recognizes full use of aquatic resources in the Late Mesolithic Ertebølle Culture (5500–4000 cal BC): coastal sites are frequently found containing well-preserved fish bones, and isotope values from human collagen indicate a high dietary intake of marine resources. However, recent finds and new methodologies suggest that the view of

Light emission induced by inner-shell excitation of [Formula Presented] molecules has been investigated in the wavelength region [Formula Presented] Synchrotron radiation from the SuperACO storage ring in Orsay (France) has been used for the photoexcitation and a high-resolution secondary monochromator [Formula Presented] for the spectral analysis of the fluorescence light. Vibrationally resolved