SUMMARY: The bacterial ω-transaminase from Chromobacterium violaceum (Cv-ωTA, EC 2.6.1.18) catalyzes industrially important transamination reactions by use of the coenzyme pyridoxal 5'-phosphate (PLP). Here, we present four crystal structures of Cv-ωTA: two in the apo form, one in the holo form and one in an intermediate state, at resolutions between 1.35 and 2.4 Å. The enzyme is a homodimer with

Background. Male breast cancer (MBC) is an uncommon disease and there is limited information on the prognostic impact of routinely used clinicopathological parameters. Material and methods. In a retrospective setting, we reviewed 197 MBC patients with accessible paraffin-embedded tumor tissue and clinicopathological data. Immunohistochemical (IHC) stainings were performed on tissue microarrays and

Based on simultaneous analysis of the frequency-resolved transient grating, peak shift, and echo width signals, we present a model for the third-order optical response of carotenoids including population dynamics and system-bath interactions. Our frequency-resolved photon echo experiments show that the model needs to incorporate the excited-state absorption from both the S-2 and the S-1 states. We

Self-inflicted aggressive behaviour is a cross diagnostic phenomenon of major clinical relevance in psychiatric setting. Accumulating evidence speaks for a role of metabolic and immunological factors in aggressive behaviour. The aim of this thesis is to enlighten the role of leptin, insulin, glucagon, glucose and IL-1beta in the context of self-inflicted aggressive behaviour. We used cerebrospinal

The research network "Basic Concepts for Convection Parameterization in Weather Forecast and Climate Models" was organized with European funding (COST Action E50905) for the period of 2010-2014. Its extensive brainstorming suggests how the subgrid-scale parameterization problem in atmospheric modeling, especially for convection, can be examined and developed from the point of view of a robust theo

We have investigated the adsorption and decomposition of ethanol on the Rh(111) and Rh(5 5 3) surfaces at room temperature with special emphasis on the dehydrogenation. We use high resolution Core level photoemission and density functional theory (DFT) based simulations. A detailed analysis of the C1s core level spectra, including analysis of the vibrational fine-structure and comparison to calcul

In this paper, the automatically generated mechanism for hexadecane with both high and low temperature chemistry included is compared to a systematically generated mechanism by hand. In contrast to other systems for automatic generation, the REACTION system uses pathways to organize the application of reaction classes. A pathway is a sequence of reaction classes where only those species produced b

Thirty-five new species of the lichen family Teloschistaceae are described: Caloplaca aseptatospora S. Y. Kondr. & Kärnefelt, C. bartlettii S. Y. Kondr. & Kärnefelt, C. begaensis S. Y. Kondr. & Kärnefelt, C. burneyensis S. Y. Kondr. & Kärnefelt, C. cliffwetmorei S. Y. Kondr. & Kärnefelt, C. dorrigoensis S. Y. Kondr. & Kärnefelt, Caloplaca erichansenii S. Y. Kondr., A. Thell

Nanowires grown with the vapor-liquid-solid method commonly exhibit polytypism, showing both zincblende and wurtzite crystal structure. We have grown p-type InP nanowires using DEZn as a dopant precursor and studied the wetting of the seed particle and the nanowire crystal structure. The nanowires grown with high DEZn molar fractions exhibit deformed seed particles after growth. We observe 20% sma

A search for squarks and gluinos in final states containing jets, missing transverse momentum and no electrons or muons is presented. The data were recorded by the ATLAS experiment in root s = 7 TeV proton-proton collisions at the Large Hadron Collider. No excess above the Standard Model background expectation was observed in 35 pb(-1) of analysed data. Gluino masses below 500 GeV are excluded at

Background: The study presented here has used the commercial flow sheeting program Aspen Plus (TM) to evaluate techno-economic aspects of large-scale hemp-based processes for producing transportation fuels. The co-production of biogas, district heat and power from chopped and steam-pretreated hemp, and the co-production of ethanol, biogas, heat and power from steam-pretreated hemp were analysed. T

The antiviral activities of type I IFNs have long been established. However, comparatively little is known of their role in defenses against nonviral pathogens. We examined here the effects of type I IFNs on host resistance against the model pathogenic yeast Cryptococcus neoformans. After intratracheal or i.v. challenge with this fungus, most mice lacking either the IFN-alpha/beta receptor (IFN-al

Surging outlet glaciers are important in draining large ice caps, but the mechanisms controlling surge periodicities are poorly known. We investigated a sediment sequence from the glacier-fed Lake Logurinn in eastern Iceland, and our unique annually resolved data, based on sedimentary varves, imply that Eyjabakkajokull, an outlet glacier of Vatnajokull, began surging about 2200 cal a BP (before 19

This letter presents dc characteristics and low-frequency noise (LFN) measurements on single vertical InAs nanowire MOSFETs with 35-nm gate length and HfO2 high-kappa dielectric. The average normalized transconductance for three devices is 0.16 S/mm, with a subthreshold slope of 130 mV/decade. At 10 Hz, the normalized noise power S-I/I-d(2) measures 7.3 x 10(-7) Hz(-1). Moreover, the material-depe

Famous for its many New Kingdom stelai and funerary shrines, Speos of Horemheb and magnificent quarries, this paper presents a preliminary report on a lesser acknowledged feature of Gebel el Silsila: its quarry marks. Focusing here on the northern section – Partition B – of Silsila East’s Main Quarry, seventeen individual quarry faces display totally 376 quarry marks, which have been divided into